Modulatory effects of cod liver oil on the antioxidant status and oxidative stress induced by acute exposure to carbon tetrachloride (CCL4) in experimental animal models
-
Abam Esther Omugba
and
Eze Agofure
Abstract
Background: This work was designed to investigate the modulatory effects of cod liver oil on the acute exposure to carbon tetrachloride (CCL4) in experimental animal models.
Methods: Markers of oxidative stress, enzymic and non-enzymic antioxidants were assessed in the liver and kidney.
Results: The results showed significant (p<0.05) increase in the total protein of the kidney of rats pretreated with cod liver oil compared to the control and CCL4-treated groups. Acute exposure to CCL4 also significantly (p<0.05) increased thiobarbituric acid reactive substances in the liver of rats treated with cod liver oil compared to the CCL4-treated rats. The reduced glutathione (GSH) content in the liver of the rats administered with CCL4 decreased significantly compared to that in all other treatment groups, whereas rats pretreated and co-administered with cod liver oil and CCl4 showed significant (p<0.05) improvement in the liver GSH content. The catalase (CAT) activity in the liver of rats exposed to CCL4 decreased (p<0.05) significantly, whereas the activity increased (p<0.05) significantly in the rats that were treated with cod liver oil compared to the CCl4 only-treated group. The percentage inhibition of superoxide dismutase (SOD) increased (p<0.05) significantly in the liver of rats administered cod liver oil compared to the CCL4-treated rats and the control.
Conclusions: Taken together, cod liver oil attenuates CCL4-induced toxicity and oxidative stress in the liver but not in the kidney of rats acutely exposed to CCL4.
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Articles in the same Issue
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- Acute high blood glucose level attenuates histamine-stimulated acid secretion in male Wistar rats
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- Erythrina lysistemon-derived flavonoids account only in part for the plant’s specific effects on rat uterus and vagina
- A prospective drug use evaluation of antihypertensive drugs in in-patients of a tertiary referral care hospital
- Role for monoaminergic systems in the antidepressant and anxiolytic properties of the hydroethanolic leaf extract from Adenia cissampeloides
- Short Communication
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Articles in the same Issue
- Frontmatter
- Genotoxicity and Cytotoxicity
- Randomized, double-blind, placebo-controlled study to investigate the pharmacodynamic interaction of 5-HT3 antagonist ondansetron and paracetamol in postoperative patients operated in an ENT department under local anesthesia
- Influence of vitamin E and quercetin on Nigerian Bonny Light crude oil-induced neuronal and testicular toxicity in Wistar rats
- Vascular Conditions
- Reduction of pressor response to stress by centrally acting apelin in spontaneously hypertensive rats
- Oxidative Stress
- Protective effects of blackberry and quercetin on sodium fluoride-induced oxidative stress and histological changes in the hepatic, renal, testis and brain tissue of male rat
- Modulatory effects of cod liver oil on the antioxidant status and oxidative stress induced by acute exposure to carbon tetrachloride (CCL4) in experimental animal models
- Hematological Profile
- Acute high blood glucose level attenuates histamine-stimulated acid secretion in male Wistar rats
- Inflammation
- Physiological characteristics of crab Portunus sanguinolentus egg mass extract from southeast coast of India
- Phytotherapy
- Attenuating effect of standardized lyophilized Cinnamomum zeylanicum bark extract against streptozotocin-induced experimental dementia of Alzheimer’s type
- Erythrina lysistemon-derived flavonoids account only in part for the plant’s specific effects on rat uterus and vagina
- A prospective drug use evaluation of antihypertensive drugs in in-patients of a tertiary referral care hospital
- Role for monoaminergic systems in the antidepressant and anxiolytic properties of the hydroethanolic leaf extract from Adenia cissampeloides
- Short Communication
- Anti-inflammatory effects of aqueous extract of Mangifera indica in Wistar rats
