Startseite Antioxidant activities for superoxide dismutase in patients with Crohn’s disease
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Antioxidant activities for superoxide dismutase in patients with Crohn’s disease

  • Mohammed A. Alzoghaibi EMAIL logo , Ibrahem A. Al-Mofleh und Abdulrahman M. Al-Jebreen
Veröffentlicht/Copyright: 10. Juli 2013

Abstract

Background: In this study, we aimed to determine the levels of antioxidant activity for superoxide dismutase (SOD) enzymes in patients with Crohn’s disease (CD) to investigate their contribution to tissue injury in CD.

Methods: Forty-two patients with CD and 38 matched healthy subjects (control group) were recruited. SOD enzymatic activity was measured by purely chemical system based on NAD(P)H oxidation.

Results: Plasma antioxidant activities for SOD in CD patients were significantly lower than that in the control group.

Conclusions: Low antioxidant activity for SOD in CD is an important indication of oxidative stress. CD patients are more susceptible to oxidative stress. This study supports the hypothesis that increased oxidative stress and decreased antioxidant defense in CD.


Corresponding author: Dr. Mohammed Alzoghaibi, Associate Professor, Department of Physiology/Center of Excellence in Biotechnology Research, College of Medicine, King Saud University, P.O. Box 2925 (60), Riyadh 11461, Saudi Arabia, Phone: +966-1-467-1616, Fax: +966-1-467-1430, E-mail:

This work was supported by the Research Center of the College of Medicine, King Saud University.

Conflict of interest statement

Authors’ conflict of interest disclosure: The authors stated that there are no conflicts of interest regarding the publication of this article.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

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Received: 2013-3-26
Accepted: 2013-6-12
Published Online: 2013-07-10
Published in Print: 2014-02-01

©2014 by Walter de Gruyter Berlin Boston

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