Abstract
Background: In this study, we aimed to determine the levels of antioxidant activity for superoxide dismutase (SOD) enzymes in patients with Crohn’s disease (CD) to investigate their contribution to tissue injury in CD.
Methods: Forty-two patients with CD and 38 matched healthy subjects (control group) were recruited. SOD enzymatic activity was measured by purely chemical system based on NAD(P)H oxidation.
Results: Plasma antioxidant activities for SOD in CD patients were significantly lower than that in the control group.
Conclusions: Low antioxidant activity for SOD in CD is an important indication of oxidative stress. CD patients are more susceptible to oxidative stress. This study supports the hypothesis that increased oxidative stress and decreased antioxidant defense in CD.
This work was supported by the Research Center of the College of Medicine, King Saud University.
Conflict of interest statement
Authors’ conflict of interest disclosure: The authors stated that there are no conflicts of interest regarding the publication of this article.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
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©2014 by Walter de Gruyter Berlin Boston
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Artikel in diesem Heft
- Masthead
- Masthead
- Review
- The relationship between oxidative stress and exercise
- Original articles
- Testosterone promotes glucose intolerance, lipid disorder and oxidative stress in type 1 diabetic rats
- Inhibition of key enzymes linked to type 2 diabetes and sodium nitroprusside-induced lipid peroxidation in rat pancreas by water-extractable phytochemicals from unripe pawpaw fruit (Carica papaya)
- Influence of gallic acid on oxidative stress-linked streptozotocin-induced pancreatic dysfunction in diabetic rats
- The evaluation of the hypoglycemic effect of soft drink leaf extract of Phyllanthus amarus (Euphorbiaceae) in rats
- Antioxidant activities for superoxide dismutase in patients with Crohn’s disease
- Resveratrol for prenatal-stress-induced oxidative damage in growing brain and its consequences on survival of neurons
- Hepatoprotective role of kaempferol during alcohol- and ΔPUFA-induced oxidative stress
- Evaluation of antiulcerogenic potential of antioxidant α-tocopherol in pylorus-ligated albino rats
- Comparison of the penetration and passage of Streptococcus mutans and Aggregatibacter actinomycetemcomitans through membranes loaded with tetracycline, amoxicillin, and chlorhexidine: an in vitro study
- Sodium-hydrogen exchanger inhibitory potential of Malus domestica, Musa × paradisiaca, Daucus carota, and Symphytum officinale
- Methylglyoxal causes endothelial dysfunction: the role of endothelial nitric oxide synthase and AMP-activated protein kinase α
- Reversal of alcohol induced testicular hyperlipidemia by supplementation of ascorbic acid and its comparison with abstention in male guinea pigs
- A cross-sectional study of surveillance of adverse drug reactions in inpatient departments of a tertiary care hospital