Inhibition of key enzymes linked to type 2 diabetes and sodium nitroprusside-induced lipid peroxidation in rat pancreas by water-extractable phytochemicals from unripe pawpaw fruit (Carica papaya)

References

1. Matsui T, Tanaka T, Tamura S, Toshima A, Miyata Y, Tanaka K. α-Glucosidase inhibitory profile of catechins and theaflavins. J Agric Food Chem 2007;55:99–105.10.1021/jf0627672Suche in Google Scholar

2. Bailey CJ, Day C. Avandamet: combined metformin-rosiglitazone treatment for insulin resistance in type 2 diabetes. Int J Clin Pract 2004;58:867–76.10.1111/j.1742-1241.2004.00318.xSuche in Google Scholar

3. Li WL, Zheng HC, Bukuru J, De Kimpe N. Natural medicines used in the traditional Chinese medicinal system for therapy of diabetes mellitus. J Ethnopharmacol 2004;92:1–12.10.1016/j.jep.2003.12.031Suche in Google Scholar

4. Baynes JW. Role of oxidative stress in development of complications in diabetes. Diabetes 1991;40:405–12.10.2337/diab.40.4.405Suche in Google Scholar

5. Baynes JW, Thorpe SR. Role of oxidative stress in diabetic complications: a new perspective on an old paradigm. Diabetes 1999;48:1–9.10.2337/diabetes.48.1.1Suche in Google Scholar

6. Ceriello A. Oxidative stress and glycemic regulation. Metabolism 2000;49:27–9.10.1016/S0026-0495(00)80082-7Suche in Google Scholar

7. Halliwell B, Gutteridge JM. Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol 1990;186:1–85.10.1016/0076-6879(90)86093-BSuche in Google Scholar

8. Saxena AK, Srivastava P, Kale RK, Baquer NZ. Impaired antioxidant status in diabetic rat liver – effect of vanadate. Biochem Pharmacol 1993;45:539–42.10.1016/0006-2952(93)90124-FSuche in Google Scholar

9. Maritim AC, Sanders RA, Watkins JB. Diabetes, oxidative stress, and antioxidants: a review. J Biochem Mol Toxicol 2003;17:24–38.10.1002/jbt.10058Suche in Google Scholar PubMed

10. Brownlee M. The pathobiology of diabetic complications: a unifying mechanism. Diabetes 2005;54:1615–25.10.2337/diabetes.54.6.1615Suche in Google Scholar PubMed

11. Niedowicz DM, Daleke DL. The role of oxidative stress in diabetic complications. Cell Biochem Biophys 2005;43:289–330.10.1385/CBB:43:2:289Suche in Google Scholar

12. Kwon YI, Vattem DA, Shetty K. Evaluation of clonal herbs of Lamiaceae species for management of diabetes and hypertension. Asia Pac J Clin Nutr 2006;15:107–18.Suche in Google Scholar

13. Ali H, Houghton PJ, Soumyanath A. α-Amylase inhibitory activity of some Malaysian plants used to treat diabetes; with particular reference to Phyllanthus amarus. J Ethnopharmacol 2006;107:449–55.10.1016/j.jep.2006.04.004Suche in Google Scholar

14. Kim D, Lee CY, Wrolstad TH, Acree E, Decker MH, Penner DS, et al. Extraction and isolation of polyphenolics. In: Shoemaker, editor. Current protocols in food analytical chemistry. New York: John Wiley & Sons Inc., 2002:101–2.Suche in Google Scholar

15. Shim YJ, Doo HK, Ahn SY, Kim YS. Inhibitory effect of aqueous extract from the gall of Rhus chinensis on α-glucosidase activity and postprandial blood glucose. J Ethnopharmacol 2003;85:283–7.10.1016/S0378-8741(02)00370-7Suche in Google Scholar

16. Oboh G, Akinyemi AJ, Ademiluyi AO, Adefegha SA. Inhibitory effects of aqueous extract of two varieties of ginger on some key enzymes linked to type-2 diabetes in vitro. J Food Nutr Res 2010;49:14–20.Suche in Google Scholar

17. Pinto MD, Kwon YI, Apostolidis E, Lajolo FM, Genovese MI, Shetty K. Evaluation of red currants (Ribes rubrum L), black currants (Ribes nigrum L.), red and green gooseberries (Ribes uva-crispa) for potential management of type 2 diabetes and hypertension using in vitro models. J Food Biochem 2010;34:639–60.Suche in Google Scholar

18. Ranilla LG, Kwon Y, Apostolidis E, Shetty K. Phenolic compounds, antioxidant activity and in vitro inhibitory potential against key enzymes relevant for hyperglycemia and hypertension of commonly used medicinal plants, herbs and spices in Latin America. Bioresour Technol 2010;101:4676–89.10.1016/j.biortech.2010.01.093Suche in Google Scholar

19. Bhadari MR, Jong-Anarakkan N, Hong G, Kawabata J. α-Glucosidase and α-amylase inhibitory activities of Nepalese medicinal herb Pakhanbhed (Bergenia ciliata Haw). Food Chem 2008;106:247–52.10.1016/j.foodchem.2007.05.077Suche in Google Scholar

20. McCue P, Kwon YI, Shetty K. Anti-diabetic and antihypertensive potential of sprouted and solid-state bioprocessed soybean. Asia Pac J Clin Nutr 2005;14:145–52.Suche in Google Scholar

21. Gill LS. Carica papaya L. In: Ethnomedicinal uses of plants in Nigeria. Benin City, Nigeria: Uniben Press, 1992:57–8.Suche in Google Scholar

22. Tona L, Kambu K, Ngimbi N, Cimanga K, Vlietinck AJ. Anti amoebic and phytochemical screening of some Congolese medicinal plants. J Ethnopharmacol 1998;61:57–65.10.1016/S0378-8741(98)00015-4Suche in Google Scholar

23. Fakeye TO. Hypoglycemic effect of Carica papaya. Trop J Pharm Res 2007;1:671–8.Suche in Google Scholar

24. Olagunju JA, Ogunlana CO, Gbile ZO. The hypoglycemic activity of ethanolic extracts of unripe, mature fruits of Carica papaya in alloxan-induced diabetic rats. Niger J Biochem Mol Biol 1995;10:21–3.Suche in Google Scholar

25. Olapade EO. Foods and herbs on diabetes mellitus. Ibadan, Nigeria: NARL Specialist Clinic Publications, 1995:1–5.Suche in Google Scholar

26. Salau BA, Osilesi O, Idowu GO, Musa S, Ajani EO. Effects of fruits and vegetables on cardiovascular disease risk factors in non-insulin dependent diabetes mellitus (NIDDM) subjects. Afr J Med Pharm Sci 2003;7:21–6.Suche in Google Scholar

27. National Research Council. Use of laboratory animals in biomedical and behavioral research. Washington, DC: National Academy Press, 1988:102–3.Suche in Google Scholar

28. Oboh G, Puntel RL, Rocha JB. Hot pepper (Capsicum annuum, Tepin and Capsicum chinese, Habanero) Prevents Fe²⁺-induced lipid peroxidation in brain – in vitro. Food Chem 2007;102:178–85.10.1016/j.foodchem.2006.05.048Suche in Google Scholar

29. Worthington V. α-Amylase. In: Worthington K, Worthington V, editors. Worthington enzyme manual. Freehold, NJ: Worthington Biochemical Corp., 1993:36–41.Suche in Google Scholar

30. Apostolidis E, Kwon YI, Shetty K. Inhibitory potential of herb, fruit, and fungal-enriched cheese against key enzymes linked to type 2 diabetes and hypertension. Innov Food Sci Emerg Technol 2007;8:46–54.10.1016/j.ifset.2006.06.001Suche in Google Scholar

31. Belle NA, Dalmolin GD, Fonini G, Rubim MA, Rocha JB. Polyamines reduces lipid peroxidation induced by different pro-oxidant agents. Brain Res 2004;1008:245–51.10.1016/j.brainres.2004.02.036Suche in Google Scholar

32. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reactions. Anal Biochem 1979;95:351–8.10.1016/0003-2697(79)90738-3Suche in Google Scholar

33. Mercocci L, Marguire JJ, Droy-Lefaiz MT, Parker L. The nitric oxide-scavenging properties of Ginko biloba extract EGB 761. Biochem Biophys Res Commun 1994;210:748–55.10.1006/bbrc.1994.1764Suche in Google Scholar

34. Kelley WI, Coffey DL, Mueller TC. Liquid chromatographic determination of phenolic acids in soil. J AOAC Int 1994;77:805–9.10.1093/jaoac/77.4.805Suche in Google Scholar

35. Ngounou FN, Manfouo RN, Tapondjou LA, Lontsi D, Kuete V, Penlap V, et al. Antimicrobial diterpenoid alkaloids from Erythrophleum suaveolens (Guill. & Perr.) Brenan. Bull Chem Soc Ethiop 2005;19:221–6.Suche in Google Scholar

36. Zar JH. Biostatistical analysis. USA: Prentice-Hall Inc., 1984:620.Suche in Google Scholar

37. Ortiz-Andrade RR, Garcia-Jimenez S, Castillo-Espana P, Vila GR, Villalobos-Molina R, Estrada-Soto S. α-Glucosidase inhibitory activity of the methanolic extract from Tourneforia hartwegiana: an anti-hyperglycemic agent. J Ethnopharmacol 2007;109:48–53.10.1016/j.jep.2006.07.002Suche in Google Scholar

38. Zhang J, Kashket S. Inhibition of salivary amylase by black and green teas and their effects on the intraoral hydrolysis of starch. Caries Res 1998;32:233–8.10.1159/000016458Suche in Google Scholar

39. Oboh G, Ademiluyi AO, Faloye YM. Effect of combination on the antioxidant and inhibitory properties of tropical pepper varieties against α-amylase and α-glucosidase activities in vitro. J Med Food 2011;14:1152–8.10.1089/jmf.2010.0194Suche in Google Scholar

40. Oboh G, Ademiluyi AO, Akinyemi AJ, Henle T, Saliu JA, Schwarzenbolz U. Inhibitory effect of polyphenol-rich extracts of jute leaf (Corchorus olitorius) on key enzyme linked to type 2 diabetes (α-amylase and α-glucosidase) and hypertension (angiotensin I converting) in vitro. J Funct Foods 2012;4:450–8.10.1016/j.jff.2012.02.003Suche in Google Scholar

41. Ademiluyi AO, Oboh G. Soybean phenolic-rich extracts inhibit key-enzymes linked to type 2 diabetes (α-amylase and α-glucosidase) and hypertension (angiotensin I converting enzyme) in vitro. Exp Toxicol Pathol 2013;65:305–9.10.1016/j.etp.2011.09.005Suche in Google Scholar

42. Oboh G, Ademosun AO. Shaddock peels (Citrus maxima) phenolic extracts inhibit α-amylase, α-glucosidase and angiotensin I-converting enzyme activities: a nutraceutical approach to diabetes management. Diabetes Metab Syndr: Clin Res Rev 2011;5:148–52.10.1016/j.dsx.2012.02.008Suche in Google Scholar

43. Oberley LW. Free radicals and diabetes. Free Radic Biol Med 1988;5:113–24.10.1016/0891-5849(88)90036-6Suche in Google Scholar

44. Bates JN, Baker MT, Guerra R, Harrison DG. Nitric oxide generation from nitroprusside by vascular tissue. Biochem Pharmacol 1990;42:157–65.10.1016/0006-2952(91)90406-USuche in Google Scholar

45. Beckman JS, Koppenol WH. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Physiol 1996;271:1424–37.10.1152/ajpcell.1996.271.5.C1424Suche in Google Scholar PubMed

46. Bartesaghi S, Valez V, Trujillo M, Peluffo G, Romero N, Zhang H. Mechanistic studies of peroxynitrite-mediated tyrosine nitration in membranes using the hydrophobic probe N-t-BOC-L-tyrosine tert-butyl ester. Biochemistry 2006;45:6813–25.10.1021/bi060363xSuche in Google Scholar PubMed

47. Pacher P, Szabot C. Role of the peroxynitrite-poly (ADP-ribose) polymerase pathway in human disease. Am J Pathol 2008;173:2–13.10.2353/ajpath.2008.080019Suche in Google Scholar PubMed PubMed Central

48. Komjati K, Besson VC, Szabo C. Poly (ADP-ribose) polymerase inhibitors as potential therapeutic agents in stroke and neurotrauma. Curr Drug Targets CNS Neurol Disord 2005; 4:179–94.10.2174/1568007053544138Suche in Google Scholar PubMed

49. Klotz LO, Sies H. Defenses against peroxynitrite: seleno compounds and flavonoids. Toxicol Lett 2003;140:125–32.Suche in Google Scholar

50. Moncada S, Palmer RM, Higgs EA. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 1991;43:109–42.Suche in Google Scholar

51. Halliwell B, Gutteridge JM. Free radicals in biology and medicine, 3rd ed. Oxford, UK: Oxford University Press, 1999:936.Suche in Google Scholar

52. Cheplick S, Kwon Y, Bhowmik P, Shetty K. Clonal variation in raspberry fruit phenolics and relevance for diabetes and hypertension management. J Food Biochem 2007;31:656–79.10.1111/j.1745-4514.2007.00136.xSuche in Google Scholar

53. Chu Y, Sun J, Wu X, Liu RH. Antioxidant and antiproliferative activity of common vegetables. J Agric Food Chem 2002;50:6910–16.10.1021/jf020665fSuche in Google Scholar PubMed

54. Sun J, Chu Y, Wu X, Liu R. Antioxidant and antiproliferative activities of common fruits. J Agric Food Chem 2002;50: 7449–54.10.1021/jf0207530Suche in Google Scholar PubMed

55. Oboh G, Rocha JB. Polyphenols in red pepper [Capsicum annuum var. aviculare (Tepin)] and their protective effect on some pro-oxidants induced lipid peroxidation in brain and liver. Eur Food Res Technol 2007;225:239–47.10.1007/s00217-006-0410-1Suche in Google Scholar

56. Amic D, Davidovic-Amic D, Beslo D, Trinajstic N. Structure-related scavenging activity relationship of flavonoids. Croatia Chem Acta 2003;76:55–61.Suche in Google Scholar

57. Krishna KL, Paridhavi M, Jagruti J. Review on nutritional, medicinal, and pharmacological properties of papaya (Carica papaya Linn). Nat Prod Radiance 2008;7:364–73.Suche in Google Scholar

58. Yifei Z, Xiaoying L, Dajin Z, Wei L, Jialin Y, Na Z, et al. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab 2008;93:2559–65.10.1210/jc.2007-2404Suche in Google Scholar PubMed