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Physicochemical Treatment of Three Chemotherapy Drugs: Irinotecan, Tamoxifen, and Cyclophosphamide
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Zhuo Chen
Veröffentlicht/Copyright:
30. November 2016
Abstract
The removal of three chemotherapy drugs including irinotecan, tamoxifen, and cyclophosphamide in water was examined by both physical and chemical treatment processes. Powdered activated carbon (PAC) absorption tests and oxidation by ozone or an advanced oxidation process (hydrogen peroxide and ultraviolet irradiation) were conducted on de-ionized water samples spiked with these drugs. Liquid chromatography coupled with tandem mass spectroscopy was successfully applied for the selective and sensitive determination of these three compounds. Removal of the three selected drugs in water samples by PAC was found to be dependant on PAC dosage. The Freundlich isotherm coefficients revealed the PAC absorption capacity sequence as tamoxifen > irinotecan > cyclophosphamide. Ozone was found to be effective in removing tamoxifen and irinotecan but not able to destroy cyclophosphamide in water. Advanced oxidation processes such as UV/H2O2 were capable of removing all three tested chemotherapy drugs more rapidly compared to ozone alone. This research suggests that treatment processes located within hospitals, wastewater treatment plants or drinking water treatment plants would be able to achieve partial removal of several chemotherapy drugs.
Received: 2008-3-31
Revised: 2008-5-2
Accepted: 2008-5-6
Published Online: 2016-11-30
Published in Print: 2008-7-1
© 2016 by Walter de Gruyter Berlin/Boston
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Schlagwörter für diesen Artikel
Physicochemical treatment;
Chemotherapy drugs;
Absorption;
Oxidation
Artikel in diesem Heft
- Glycerol Transformation Through Photocatalysis: A Possible Route to Value Added Chemicals
- Photocatalytic Degradation of Methylene Blue on Fixed Powder Layers: Which Limitations are to be Considered?
- Surface Modification of TiO2 with Ascorbic Acid for Heterogeneous Photocatalysis: Theory and Experiment
- Vacuum-UV- (VUV-) Photochemically Initiated Oxidation of Dimethylamine in the Gas Phase
- Metal-Oxide Photoassisted Degradation of Binary Systems of Cationic / Anionic Surfactants and their Components in Aqueous Dispersions
- Photochromic and Photocatalytic Inorganic-Organic Multilayer Films based on Polyoxometalates and Poly(ethylenimine)
- Biodegradation of Photo-Fenton Pre-Treated Solutions of Sulfamethoxazole by Aerobic Communities. Molecular Biology Techniques Applied to the Determination of Existing Strains
- Oxidation of Pesticides in Water by Fenton and Photo-Fenton Reactions
- Physicochemical Treatment of Three Chemotherapy Drugs: Irinotecan, Tamoxifen, and Cyclophosphamide
- Comparison of Photo-Fenton Treatment and Coupled Photo-Fenton and Biological Treatment for Detoxification of Pharmaceutical Industry Contaminants
- Integration of Environmental and Economic Performance of Processes. Case Study on Advanced Oxidation Processes for Wastewater Treatment
- Remediation of Water Contaminated with Pesticides by Indirect Electrochemical Oxidation Process Electro-Fenton
- Adsorption and Photocatalytic Degradation of Phthalic Acid on TiO2 and ZnO
- Treatment of Phenol, Formaldehyde and their Mixtures by Photocatalytic and Biological Methods
- Photoelectrocatalytic Activity of Electrosynthesised Tungsten Trioxide- Titanium Dioxide Bi-Layer Coatings for the Photooxidation of Organics
- Heterogeneous Photocatalytic Degradation of Acid Dyes in Aqueous TiO2 Suspensions: Kinetics and Toxicity
- Neural Networks and Genetic Algorithms Optimization of the Photocatalytic Degradation of Alcian Blue 8GX
- Super-Hydrophilic and Photocatalytic Properties of Ag-TiO2 Thin Films Prepared by Sol–Gel Technique
- Aerobic Bio-oxidation with Ozonation for Recalcitrant Wastewater Treatment
- Photochemical Reactivity of Iron(III)-Doped Ruthenium(II)-tris- Bipyridine/Titanium Dioxide Zeolite Y Photocatalysts at High Substrate Concentrations
- Effect of Contaminant Hydrophobicity in the Treatment of Contaminated Soils by Catalyzed H2O2 Propagations (Modified Fenton’s Reagent)
- Preparation of Photocatalytic Coatings Adapted to the Elimination of Airborne Pollutants: Influence of the Substrate on the Degradation Efficiency
- Ozonation of Landfill Leachates: Treatment Optimization by Factorial Design
- Ozone Transfer and Decomposition of Isopropyl Alcohol by H2O2/Ozone Process in a Rotating Packed Contactor
- Photocatalytic Destruction of Geosmin Using Novel Pelleted Titanium Dioxide
- Re-Utilization of Exhaustion Baths in Cotton-Dyeing Processes After Solar-Based Photo-Oxidative Treatments
- Advanced Oxidation of a Commercial Naphthalene Sulphonic Acid: Effects on Organic Carbon and Toxicity Removals
- Highly Photoactive Monodidisperse Titania Hollow Nanospheres
- Degradation of Phenylmercury Compounds by Heterogeneous Photocatalysis Over α-Fe2O3
