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Computational study of intravenous magnetic drug targeting using implanted magnetizable stent

  • Andrej Krafcik ORCID logo EMAIL logo , Melania Babincova ORCID logo , Peter Babinec ORCID logo and Ivan Frollo ORCID logo
Published/Copyright: October 10, 2022

Abstract

Magnetic carriers for guiding, delivery, and capturing of drugs to desired place attract interest in the field of smart treatment of various pathological conditions. Presented paper, therefore, deals with one such application with the theoretical model of magnetic fluid flow through vessel bifurcation with one arm treated with ferromagnetic vascular stent placed in an external originally homogeneous magnetic field. This flow was described as laminar Newtonian incompressible continuum of the magnetic many-bead system, with Reynolds number 1 , using magnetic force variant of the Nernst–Planck equation coupled with the Navier–Stokes equations, solved numerically by the finite element method (FEM). This approach allowed us to quantify capturing efficiency of magnetic beads in each arm of bifurcation vessels. Results show reduction of the number of magnetic beads entering as well as leaving the arm treated with stent in comparison with the untreated one. For stented bifurcation arm, the significant amount of beads are captured to its luminal surface, which may be used for drug delivery using magnetic carriers.


Corresponding author: Andrej Krafcik, Institute of Measurement Science, Slovak Academy of Sciences, Dubravska Cesta 9, 841 04 Bratislava, Slovakia, E-mail:

Funding source: Slovak Scientific Grant Agency

Award Identifier / Grant number: VEGA 2/0003/20

Award Identifier / Grant number: VEGA 1/0639/22

Funding source: Slovak Research and Development Agency

Award Identifier / Grant number: APVV-19-0032

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: This work was supported by the Slovak Scientific Grant Agency, projects VEGA 2/0003/20 and 1/0639/22, and within the project of the Slovak Research and Development Agency Nr. APVV-19-0032.

  3. Conflict of interest statement: The authors declare that they have no conflict of interest.

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Received: 2019-07-30
Accepted: 2022-07-24
Published Online: 2022-10-10
Published in Print: 2022-12-16

© 2022 Walter de Gruyter GmbH, Berlin/Boston

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