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Assessment of Ferrous Glycinate Liposome Absorption Using in Situ Single-Pass Perfusion Model

  • Baomiao Ding EMAIL logo , Xiangzhou Yi , Li Li and Hualin Yang
Published/Copyright: August 4, 2017

Abstract

Liposomes could be employed to improve the absorption of iron. The purpose of this study was to estimate the intestinal permeability of ferrous glycinate liposomes and to assess the effects of phytic acid, zinc and particle size on iron absorption using in situ single-pass perfusion in rats. The results showed that the absorption of ferrous glycinate liposomes was obviously higher than that of ferrous glycinate. The inhibitory effects of phytic acid and zinc on iron absorption were reduced by incorporating ferrous glycinate into liposomes. The particle size of ferrous glycinate liposomes was also a main factor for affecting iron absorption, and the intestinal permeability of the liposomes decreased with its particle size increasing. The results suggested that liposomes could be a potent delivery system to decrease the inhibitory effects of phytic acid and zinc and to enhance iron absorption. Furthermore, liposomes could alter the absorption pathways of ferrous glycinate.

Funding statement: The research was supported by the National Natural Science Foundation of China (31401477).

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Published Online: 2017-8-4

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