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New lipophilic organic nitrates: candidates for chronic skin disease therapy

  • Elisabetta Marini , Federica Sodano , Barbara Rolando , Konstantin Chegaev , Daniela Claudia Maresca , Angela Ianaro , Giuseppe Ercolano EMAIL logo und Loretta Lazzarato EMAIL logo
Veröffentlicht/Copyright: 3. März 2023
Biological Chemistry
Aus der Zeitschrift Biological Chemistry Band 404 Heft 6

Abstract

Organic nitrates are widely used, but their chronic efficacy is blunted due to the development of tolerance. The properties of new tolerance free organic nitrates were studied. Their lipophilicity profile and passive diffusion across polydimethylsiloxane membrane and pig ear-skin, and their efficacy in tissue regeneration using HaCaT keratinocytes were evaluated. The permeation results show that these nitrates have a suitable profile for NO topical administration on the skin. Furthermore, the derivatives with higher NO release exerted a pro-healing effect on HaCaT cells. This new class of organic nitrates might be a promising strategy for the chronic treatment of skin pathologies.

Keywords: lipophilicity; organic nitrates; skin permeation; tolerance; wound healing
Corresponding authors: Giuseppe Ercolano, Department of Pharmacy, University of Naples «Federico II», via D. Montesano 49, I-80131 Naples, Italy, E-mail: ; and Loretta Lazzarato, Department of Drug Science and Technology, University of Turin, via P. Giuria 9, I-10125 Turin, Italy, E-mail:
Elisabetta Marini and Federica Sodano contributed equally.

Acknowledgments

The authors wish to thank Prof. Alberto Gasco for helpful discussions.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: This work was supported by Associazione Italiana per la Ricerca sul Cancro (AIRC) (MFAG No. 26002 to G.E)., by the Italian Government grants (PRIN 2017 No. 2017BA9LM5 to A.I.), and by Università degli Studi di Torino, Ric. Loc. 2017 and 2019 to E.M., and 2021 to K.C.

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

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Supplementary Material

This article contains supplementary material (https://doi.org/10.1515/hsz-2022-0324).

Received: 2022-11-09
Accepted: 2023-02-17
Published Online: 2023-03-03
Published in Print: 2023-05-25

© 2023 Walter de Gruyter GmbH, Berlin/Boston

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  1. Frontmatter
  2. Reviews
  3. Unravelling the genetic links between Parkinson’s disease and lung cancer
  4. Small-molecule metabolites in SARS-CoV-2 treatment: a comprehensive review
  5. Research Articles/Short Communications
  6. Molecular Medicine
  7. Dynamic regulation of eEF1A1 acetylation affects colorectal carcinogenesis
  8. New lipophilic organic nitrates: candidates for chronic skin disease therapy
  9. Cell Biology and Signaling
  10. Altered population activity and local tuning heterogeneity in auditory cortex of Cacna2d3-deficient mice
  11. Inhibition of miR-143-3p alleviates myocardial ischemia reperfusion injury via limiting mitochondria-mediated apoptosis
  12. Proteolysis
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https://doi.org/10.1515/hsz-2022-0324
Schlagwörter für diesen Artikel
lipophilicity; organic nitrates; skin permeation; tolerance; wound healing

Artikel in diesem Heft

  1. Frontmatter
  2. Reviews
  3. Unravelling the genetic links between Parkinson’s disease and lung cancer
  4. Small-molecule metabolites in SARS-CoV-2 treatment: a comprehensive review
  5. Research Articles/Short Communications
  6. Molecular Medicine
  7. Dynamic regulation of eEF1A1 acetylation affects colorectal carcinogenesis
  8. New lipophilic organic nitrates: candidates for chronic skin disease therapy
  9. Cell Biology and Signaling
  10. Altered population activity and local tuning heterogeneity in auditory cortex of Cacna2d3-deficient mice
  11. Inhibition of miR-143-3p alleviates myocardial ischemia reperfusion injury via limiting mitochondria-mediated apoptosis
  12. Proteolysis
  13. The Mycobacterium tuberculosis prolyl dipeptidyl peptidase cleaves the N-terminal peptide of the immunoprotein CXCL-10
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