Regulation of necroptosis signaling and cell death by reactive oxygen species
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Simone Fulda
Abstract
Necroptosis has recently been identified as an alternative form of programmed cell death that is characterized by defined molecular mechanisms. Reactive oxygen species (ROS) are involved in the regulation of numerous signaling pathways, as they are highly reactive and can cause (ir)reversible posttranslational modifications. While the role of ROS in other modes of cell death has been extensively studied, its impact on necroptotic signaling and cell death is far less clear. The current minireview discusses the evidence for and against a role of ROS in necroptosis.
Acknowledgments:
The expert secretarial assistance of C. Hugenberg is greatly appreciated.
Funding organizations: This work has been partially supported by grants from the Deutsche Forschungsgemeinschaft, the BMBF, European Community, IUAPVII, and Wilhelm-Sander Stiftung.
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©2016 by De Gruyter
Artikel in diesem Heft
- Frontmatter
- Guest Editorial
- Mitochondria, redox signaling and cell death in cancer
- HIGHLIGHT: EMBO WORKSHOP “MITOCHONDRIA, APOPTOSIS AND CANCER 2015”
- The anti-oxidant and pro-oxidant dichotomy of Bcl-2
- Mitosis and mitochondrial priming for apoptosis
- The role of Her2 and other oncogenes of the PI3K/AKT pathway in mitochondria
- Mechanisms of mitophagy: putting the powerhouse into the doghouse
- Controlling quality and amount of mitochondria by mitophagy: insights into the role of ubiquitination and deubiquitination
- Coordination of stress, Ca2+, and immunogenic signaling pathways by PERK at the endoplasmic reticulum
- Regulation of necroptosis signaling and cell death by reactive oxygen species
- Contrasting effects of cardiac glycosides on cisplatin- and etoposide-induced cell death
- iBH3: simple, fixable BH3 profiling to determine apoptotic priming in primary tissue by flow cytometry
- Review
- The impact of recent advances in genetics in understanding disease mechanisms underlying the long QT syndromes
Artikel in diesem Heft
- Frontmatter
- Guest Editorial
- Mitochondria, redox signaling and cell death in cancer
- HIGHLIGHT: EMBO WORKSHOP “MITOCHONDRIA, APOPTOSIS AND CANCER 2015”
- The anti-oxidant and pro-oxidant dichotomy of Bcl-2
- Mitosis and mitochondrial priming for apoptosis
- The role of Her2 and other oncogenes of the PI3K/AKT pathway in mitochondria
- Mechanisms of mitophagy: putting the powerhouse into the doghouse
- Controlling quality and amount of mitochondria by mitophagy: insights into the role of ubiquitination and deubiquitination
- Coordination of stress, Ca2+, and immunogenic signaling pathways by PERK at the endoplasmic reticulum
- Regulation of necroptosis signaling and cell death by reactive oxygen species
- Contrasting effects of cardiac glycosides on cisplatin- and etoposide-induced cell death
- iBH3: simple, fixable BH3 profiling to determine apoptotic priming in primary tissue by flow cytometry
- Review
- The impact of recent advances in genetics in understanding disease mechanisms underlying the long QT syndromes
