Abstract
Since entering our cells in an endosymbiotic event one billion years ago, mitochondria have shaped roles for themselves in metabolism, inflammation, calcium storage, migration, and cell death. Given this critical role in cellular homeostasis it is essential that they function correctly. Equally critical is the ability of a cell to remove damaged or superfluous mitochondria to avoid potential deleterious effects. In this review we will discuss the various mechanisms of mitochondrial clearance, with a particular focus on Parkin/PINK1-mediated mitophagy, discuss the impact of altered mitophagy in ageing and disease, and finally consider potential therapeutic benefits of targeting mitophagy.
Acknowledgements
The Tait laboratory is supported by funding from Cancer Research UK, BBSRC, EU, Breast Cancer Now, Royal Society and Tenovus Scotland. S.W.G.T is a Royal Society University Research Fellow. The figures were generated, in part, using images provided by Servier Medical Art (http://www.servier.co.uk/content/servier-medical-art).
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©2016 by De Gruyter
Artikel in diesem Heft
- Frontmatter
- Guest Editorial
- Mitochondria, redox signaling and cell death in cancer
- HIGHLIGHT: EMBO WORKSHOP “MITOCHONDRIA, APOPTOSIS AND CANCER 2015”
- The anti-oxidant and pro-oxidant dichotomy of Bcl-2
- Mitosis and mitochondrial priming for apoptosis
- The role of Her2 and other oncogenes of the PI3K/AKT pathway in mitochondria
- Mechanisms of mitophagy: putting the powerhouse into the doghouse
- Controlling quality and amount of mitochondria by mitophagy: insights into the role of ubiquitination and deubiquitination
- Coordination of stress, Ca2+, and immunogenic signaling pathways by PERK at the endoplasmic reticulum
- Regulation of necroptosis signaling and cell death by reactive oxygen species
- Contrasting effects of cardiac glycosides on cisplatin- and etoposide-induced cell death
- iBH3: simple, fixable BH3 profiling to determine apoptotic priming in primary tissue by flow cytometry
- Review
- The impact of recent advances in genetics in understanding disease mechanisms underlying the long QT syndromes
Artikel in diesem Heft
- Frontmatter
- Guest Editorial
- Mitochondria, redox signaling and cell death in cancer
- HIGHLIGHT: EMBO WORKSHOP “MITOCHONDRIA, APOPTOSIS AND CANCER 2015”
- The anti-oxidant and pro-oxidant dichotomy of Bcl-2
- Mitosis and mitochondrial priming for apoptosis
- The role of Her2 and other oncogenes of the PI3K/AKT pathway in mitochondria
- Mechanisms of mitophagy: putting the powerhouse into the doghouse
- Controlling quality and amount of mitochondria by mitophagy: insights into the role of ubiquitination and deubiquitination
- Coordination of stress, Ca2+, and immunogenic signaling pathways by PERK at the endoplasmic reticulum
- Regulation of necroptosis signaling and cell death by reactive oxygen species
- Contrasting effects of cardiac glycosides on cisplatin- and etoposide-induced cell death
- iBH3: simple, fixable BH3 profiling to determine apoptotic priming in primary tissue by flow cytometry
- Review
- The impact of recent advances in genetics in understanding disease mechanisms underlying the long QT syndromes