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The anti-oxidant and pro-oxidant dichotomy of Bcl-2

  • Yi Hui Yee , Stephen Jun Fei Chong and Shazib Pervaiz EMAIL logo
Published/Copyright: April 9, 2016

Abstract

Across a wide spectrum of cellular redox status, there emerges a dichotomy of responses in terms of cell survival/proliferation and cell death. Of note, there is emerging evidence that the anti-apoptotic protein, Bcl-2, in addition to its conventional activity of titrating the pro-apoptotic effects of proteins such as Bax and Bak at the mitochondria, also impacts cell fate decisions via modulating cellular redox metabolism. In this regard, both pro- and anti-oxidant effects of Bcl-2 overexpression have been described under different conditions and cellular contexts. In this short review, we attempt to analyze existing observations and present a probable explanation for the seemingly conflicting redox regulating activity of Bcl-2 from the standpoint of its pro-survival function. The consequential effect(s) of the dual redox functions of Bcl-2 are also discussed, particularly from the viewpoint of developing novel therapeutic strategies against cancers rendered refractory due to the aberrant expression of Bcl-2.

Funding source: Ministry of Education

Award Identifier / Grant number: MOE-Tier 2; MOE2013-T2-2-130

Award Identifier / Grant number: NMRC/CIRG/1328/2012

Funding statement: We like to apologize to all authors whose contributions might have been inadvertently overlooked. S.P. is supported by grants from the Ministry of Education (MOE-Tier 2; MOE2013-T2-2-130), Singapore and the National Medical Research Council (NMRC/CIRG/1328/2012), Singapore.

Acknowledgments

We like to apologize to all authors whose contributions might have been inadvertently overlooked. S.P. is supported by grants from the Ministry of Education (MOE-Tier 2; MOE2013-T2-2-130), Singapore and the National Medical Research Council (NMRC/CIRG/1328/2012), Singapore.

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Received: 2016-1-29
Accepted: 2016-3-31
Published Online: 2016-4-9
Published in Print: 2016-7-1

©2016 by De Gruyter

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