Abstract
Platelet activation at sites of vascular injury leads to the formation of a hemostatic plug and is crucial for hemostasis. However, uncontrolled platelet activation may lead to the formation of occlusive thrombi. Several soluble or matricellular proteins can activate platelets. In this article, we review recent advances in knowledge of the role of galectins in platelet physiology. In soluble or immobilized form, these endogenous glycan-binding proteins trigger platelet activation through the modulation of discrete signaling pathways. We discuss the role of platelet–galectin interactions not only in hemostasis, but also in chronic inflammation, atherosclerosis and cancer.
Work in M.S.’s and G.A.R.’s laboratories is supported by grants from the National Agency for Promotion of Science and Technology (Argentina) and National Council for Scientific and Technical Investigation (CONICET, Argentina). Work in G.A.R.’s lab is supported by the Sales Foundation for Cancer (Argentina), University of Buenos Aires (Argentina), and National Multiple Sclerosis Society (USA).
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©2013 by Walter de Gruyter Berlin Boston
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Articles in the same Issue
- Masthead
- Masthead
- Reviews
- Glucocerebrosidase, a new player changing the old rules in Lewy body diseases
- Comparison of natural and recombinant tissue factor proteins: new insights
- Targeting caspases in cancer therapeutics
- When stable RNA becomes unstable: the degradation of ribosomes in bacteria and beyond
- Minireviews
- Galectins: new agonists of platelet activation
- Antitumor effects of energy restriction-mimetic agents: thiazolidinediones
- Research Articles/Short Communications
- Protein Structure and Function
- Biochemical characterization of an S-adenosyl-l-methionine-dependent methyltransferase (Rv0469) of Mycobacterium tuberculosis
- Immunologically active peptides that accompany hen egg yolk immunoglobulin Y: separation and identification
- Membranes, Lipids, Glycobiology
- Potential importance of Maackia amurensis agglutinin in non-small cell lung cancer
- Molecular Medicine
- Kinin B1 receptor gene ablation affects hypothalamic CART productionb
- Cell Biology and Signaling
- Effects of lipotoxicity on a novel insulin-secreting human pancreatic β-cell line, 1.1B4