Exportin T and Exportin 5: tRNA and miRNA biogenesis – and beyond
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Matthias S. Leisegang
Abstract
The biogenesis of most eukaryotic kinds of RNA requires nuclear export, which is mediated by a variety of specific nuclear transport receptors. The nuclear export receptors Exportin-t (Exp-t) and Exportin 5 (Exp5), and their homologues, are involved in the export of transfer RNA to the cytoplasm. Exp5 is further involved in additional nucleocytoplasmic transport pathways, which include nuclear export of microRNA precursors (pre-miRNAs) and pre-60S ribosomal subunits. Inactivation of Exp5 results in nuclear accumulation of pre-miRNAs and perturbation of gene expression, and its mutation was recently found in malignant diseases. Here, we compare the cellular function of Exp5 and Exp-t with focus on Exp5 substrates and its role in diseases.
©2012 by Walter de Gruyter Berlin Boston
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Artikel in diesem Heft
- Masthead
- Masthead
- Reviews
- Mitophagy: mechanisms, pathophysiological roles, and analysis
- Zinc networks: the cell-specific compartmentalization of zinc for specialized functions
- Cyclophilin involvement in the replication of hepatitis C virus and other viruses
- Minireviews
- TDP-43 in central nervous system development and function: clues to TDP-43-associated neurodegeneration
- Platelet function and thymosin β4
- Exportin T and Exportin 5: tRNA and miRNA biogenesis – and beyond
- Genes and Nucleic Acids
- Biological and molecular analysis of the pathogenic variant C3 of potato spindle tuber viroid (PSTVd) evolved during adaptation to chamomile (Matricaria chamomilla)
- Protein Structure and Function
- Heterologous production and functional and thermodynamic characterization of cation diffusion facilitator (CDF) transporters of mesophilic and hyperthermophilic origin
- Functional characterization of the Mycobacterium tuberculosis zinc metallopeptidase Zmp1 and identification of potential substrates
- Antimicrobial activity of human islet amyloid polypeptides: an insight into amyloid peptides’ connection with antimicrobial peptides
- Cell Biology and Signaling
- Necroptosis modulated by autophagy is a predominant form of melanoma cell death induced by sanguilutine
