Abstract
Objectives
This study aims to investigate the population status of selenium in Colombia and other associated factors.
Methods
Cross-sectional study, in population of urban or rural origin (n=412). Main outcome measures were: median serum selenium, thyrotropin, the prevalence of and positivity of anti-thyroid peroxidase, anti-thyroglobulin, and anti-TSH receptor.
Results
This study found that 96.6% of the subjects had normal selenium levels, and no significant associations were found between the population median of selenium and overweight/obesity, sociodemographic variables, age, goiter, and thyroid antibody positivity.
Conclusions
In Colombia, the population status of selenium is normal, and the geological characteristics may contribute to the state of selenium in this population. However, additional studies are required to evaluate the content of selenium in plants and other foods.
Acknowledgments
We appreciate the support of the Asociación Colombiana de Endocrinología Diabetes y Metabolismo, and of the Laboratorio Clínico Especializado Martha Cecilia Perdomo, Popayán-Colombia.
-
Research funding: None declared.
-
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
-
Competing interests: Authors state no conflict of interest.
-
Informed consent: Informed consent was obtained from all individuals included in this study.
-
Ethical approval: The local Institutional Review Board deemed the study exempt from review.
-
Data availability: The authors declare that data supporting the findings of this study are available within the article.
References
1. Birringer, M, Pilawa, S, Flohé, L. Trends in selenium biochemistry. Nat Prod Rep 2002;19:693–718. https://doi.org/10.1039/b205802m.Search in Google Scholar PubMed
2. Fordyce, F. Selenium geochemistry and health. Ambio 2007;36:94–7. https://doi.org/10.1579/0044-7447(2007)36[94:sgah]2.0.co;2.10.1579/0044-7447(2007)36[94:SGAH]2.0.CO;2Search in Google Scholar
3. Santi, C, Bagnoli, L. Celebrating two centuries of research in selenium chemistry: state of the art and new prospective. Molecules 2017;22:2124. https://doi.org/10.3390/molecules22122124.Search in Google Scholar
4. Kieliszek, M. Selenium–fascinating microelement, properties and sources in food. Molecules 2019;24:1298. https://doi.org/10.3390/molecules24071298.Search in Google Scholar
5. Kieliszek, M, Bano, I, Zare, H. A comprehensive review on selenium and its effects on human health and distribution in middle eastern countries. Biol Trace Elem Res 2022;200:971–87.10.1007/s12011-021-02716-zSearch in Google Scholar
6. Méplan, C, Hughes, DJ. The role of selenium in health and disease: emerging and recurring trends. Nutrients 2020;12:1049. https://doi.org/10.3390/nu12041049.Search in Google Scholar
7. Rayman, MP. Selenium intake, status, and health: a complex relationship. Hormones (Athens) 2020;19:9–14. https://doi.org/10.1007/s42000-019-00125-5.Search in Google Scholar
8. Gore, F, Fawell, J, Bartram, J. Too much or too little? A review of the conundrum of selenium. J Water Health 2010;8:405–16. https://doi.org/10.2166/wh.2009.060.Search in Google Scholar
9. Ferguson, LR, Karunasinghe, N. Nutrigenetics, nutrigenomics, and selenium. Front Genet 2011;2:15. https://doi.org/10.3389/fgene.2011.00015.Search in Google Scholar
10. Shimada, BK, Alfulaij, N, Seale, LA. The impact of selenium deficiency on cardiovascular function. Int J Mol Sci 2021;22:10713. https://doi.org/10.3390/ijms221910713.Search in Google Scholar
11. Wang, L, Yin, J, Yang, B, Qu, C, Lei, J, Han, J, et al.. Serious selenium deficiency in the serum of patients with Kashin-Beck disease and the effect of nano-selenium on their chondrocytes. Biol Trace Elem Res 2020;194:96–104. https://doi.org/10.1007/s12011-019-01759-7.Search in Google Scholar PubMed
12. World Health Organization-WHO. International Council for Control of Iodine Deficiency Disorders. Assess-ment of iodine deficiency disorders and monitoring their elimination. A guide programmed managers, 2nd ed. Geneva, Switzerland: WHO, Department of Nutrition for Health and Development; 2001, (WHO/NHD/01.1).Search in Google Scholar
13. Viduetsky, A, Herrejon, CL. Sonographic evaluation of thyroid size: a review of important measurement parameters. J Diagn Med Sonogr 2019;35:206–10. https://doi.org/10.1177/8756479318824290.Search in Google Scholar
14. https://www.dane.gov.co/index.php/estadisticas-por-tema/demografia-y-poblacion/proyecciones-de-poblacion [Accessed Dec 2017].Search in Google Scholar
15. https://www2.sgc.gov.co/sgc/mapas/Paginas/AtlasGeoquimico.aspx. [Accessed Jun 2021].Search in Google Scholar
16. https://miig.sgc.gov.co/Paginas/Resultados.aspx?k=Distribuci%C3%B3n+espacial+de+selenio+en+suelos+y+su+comportamiento+geoqu%C3%ADmico+local+al+oriente+de+los+municipios+de+Utica+y+Villeta [Accessed 29 Jun 2021].Search in Google Scholar
17. Benavidez, ST, Silva, F. Seleniosis. Instituto Geográfico Agustín Codazzi. Dpto. Agrología; 1965, vol 1. Available from: http://recordcenter.sgc.gov.co/B3/12007010002490/documento/pdf/0101024901101000.pdf [Accessed 29 Jun 2021].Search in Google Scholar
18. Zhu, J, Wang, N, Li, S, Li, L, Su, H, Liu, C. Distribution and transport of selenium in Yutangba, China: impact of human activities. Sci Total Environ 2008;392:252–61. https://doi.org/10.1016/j.scitotenv.2007.12.019.Search in Google Scholar PubMed
19. Yuan, L, Yin, X, Zhu, Y, Li, F, Huang, Y, Liu, Y, Lin, Z. Selenium in plants and soils, and selenosis in Enshi, China: implications for selenium biofortification. In: Yin, X, Yuan, L, editors. Phytoremediation and biofortification. Dordrecht: Springer; 2012:7–31 pp.10.1007/978-94-007-1439-7_2Search in Google Scholar
20. Qin, H-B, Zhu, J-M, Liang, L, Wang, M-S, Su, H. The bioavailability of selenium and risk assessment for human selenium poisoning in high-Se areas. Environ Int 2013;52:66–74. https://doi.org/10.1016/j.envint.2012.12.003.Search in Google Scholar PubMed
21. Sharma, N, Prakash, R, Srivastava, A, Sadana, US, Acharya, R, Prakash, NT, et al.. Profile of selenium in soil and crops in seleniferous area of Punjab, India by neutron activation analysis. J Radioanal Nucl Chem 2009;281:59–62. https://doi.org/10.1007/s10967-009-0082-y.Search in Google Scholar
22. Dhillon, KS, Dhillon, SK. Selenium in groundwater and its contribution towards daily dietary Se intake under different hydrogeological zones of Punjab. J Hydrol 2016;533:615–26. https://doi.org/10.1016/j.jhydrol.2015.12.016.Search in Google Scholar
23. Yasin, M, El Mehdawi, AF, Jahn, CE, Anwar, A, Turner, MFS, Faisal, M, et al.. Seleniferous soils as a source for production of selenium-enriched foods and potential of bacteria to enhance plant selenium uptake. Plant Soil 2015;386:385–94. https://doi.org/10.1007/s11104-014-2270-y.Search in Google Scholar
24. Ferreira, KS, Gomes, JC, Bellato, CR, Jordão, CP. Selenium content in Brazilian foods. Pan Am J Public Health 2002;11:171–7.10.1590/S1020-49892002000300006Search in Google Scholar
25. dos Reis, AR, El-Ramady, H, Santos, EF, Gratão, PL, Schomburg, L. Overview of selenium deficiency and toxicity worldwide: affected areas, selenium-related health issues, and case studies. In: Pilon-Smits, E, Winkel, L, Lin, ZQ, editors. Selenium in plants. Plant ecophysiology. Cham: Springer; 2017, vol 11.10.1007/978-3-319-56249-0_13Search in Google Scholar
26. Hossain, A, Skalicky, M, Brestic, M, Maitra, S, Sarkar, S, Ahmad, Z, et al.. Selenium biofortification: roles, mechanisms, responses and prospects. Molecules 2021;26:881. https://doi.org/10.3390/molecules26040881.Search in Google Scholar PubMed PubMed Central
27. Hasanuzzaman, M, Bhuyan, MHMB, Raza, A, Hawrylak-Nowak, B, Matraszek-Gawron, R, Nahar, K, et al.. Selenium toxicity in plants and environment: biogeochemistry and remediation possibilities. Plants 2020;9:1711. https://doi.org/10.3390/plants9121711.Search in Google Scholar PubMed PubMed Central
28. Malisa, EP. The behaviour of selenium in geological processes. Environ Geochem Health 2001;23:137–58. https://doi.org/10.1023/a:1010908615486.10.1023/A:1010908615486Search in Google Scholar
29. Hincapie, G, Jaramillo, JM, Rodríguez, JV, Aguilera, R, Bermúdez, H, Ortíz, S, et al.. Evaluación geológica y prospectividad de la Cuenca Cauca-Patía, Colombia. Ing Invest Desarro 2009;9:37–42.Search in Google Scholar
30. http://atlas.ideam.gov.co/basefiles/cauca_texto.pdf (Accessed 29 Jul 2021).Search in Google Scholar
31. Eliopoulos, GD, Eliopoulos, I-PD, Tsioubri, M, Economou-Eliopoulos, M. Distribution of selenium in the soil–plant–groundwater system: factors controlling its bio-accumulation. Minerals 2020;10:795. https://doi.org/10.3390/min10090795.Search in Google Scholar
32. Xia, Y, Hill, KE, Byrne, DW, Xu, J, Burk, RF. Effectiveness of selenium supplements in a low selenium area of China. Am J Clin Nutr 2005;81:829–34. https://doi.org/10.1093/ajcn/81.4.829.Search in Google Scholar PubMed
33. Yang, GQ, Xia, YM. Studies on human dietary requirements and safe range of dietary intakes of selenium in China and their application in the prevention of related endemic diseases. Biomed Environ Sci 1995;8:187–201.Search in Google Scholar
34. Hughes, DJ, Fedirko, V, Jenab, M, Schomburg, L, Méplan, C, Freisling, H, et al.. Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort. Int J Cancer 2015;136:1149–61. https://doi.org/10.1002/ijc.29071.Search in Google Scholar PubMed
35. Laclaustra, M, Navas-Acien, A, Stranges, S, Ordovas, JM, Guallar, E. Serum selenium concentrations and diabetes in U.S. adults: national health and nutrition examination survey (NHANES) 2003–2004. Environ Health Perspect 2009;117:1409–13. https://doi.org/10.1289/ehp.0900704.Search in Google Scholar PubMed PubMed Central
36. Winther, KH, Rayman, MP, Bonnema, SJ, Hegedüs, L. Selenium in thyroid disorders – essential knowledge for clinicians. Nat Rev Endocrinol 2020;16:165–76. https://doi.org/10.1038/s41574-019-0311-6.Search in Google Scholar PubMed
37. Rayman, MP, Duntas, LH. Selenium deficiency and thyroid disease. In: Luster, M, Duntas, L, Wartofsky, L, editors. The thyroid and its diseases. Cham: Springer; 2019. https://doi.org/10.1007/978-3-319-72102-6_9.Search in Google Scholar
38. Babić Leko, M, Gunjača, I, Pleić, N, Zemunik, T. Environmental factors affecting thyroid-stimulating hormone and thyroid hormone levels. Int J Mol Sci 2021;22:6521. https://doi.org/10.3390/ijms22126521.Search in Google Scholar PubMed PubMed Central
39. Turan, E, Turksoy, VA. Selenium, zinc, and copper status in euthyroid nodular goiter: a cross-sectional study. Int J Prev Med 2021;12:46.10.4103/ijpvm.IJPVM_337_19Search in Google Scholar
40. Kravchenko, VI, Andrusyshyna, IM, Luzanchuk, IA, Polumbryk, MO, Tarashchenko, YM. Association between thyroid hormone status and trace elements in serum of patients with nodular goiter. Biol Trace Elem Res 2020;196:393–9. https://doi.org/10.1007/s12011-019-01943-9.Search in Google Scholar PubMed
41. Lopes Junior, E, Leite, HP, Konstantyner, T. Selenium and selenoproteins: from endothelial cytoprotection to clinical outcomes. Transl Res 2019;208:85–104. https://doi.org/10.1016/j.trsl.2019.01.004.Search in Google Scholar PubMed
© 2022 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Letter to the Editor
- The role of gut microbiota in etiopathogenesis of long COVID syndrome
- Original Articles
- Risk factors and inflammatory markers in acute coronary syndrome-ST elevation myocardial infarction (STEMI)
- Association of pro-inflammatory cytokines, inflammatory proteins with atherosclerosis index in obese male subjects
- Exploration of meteorin-like peptide (metrnl) predictors in type 2 diabetic patients: the potential role of irisin, and other biochemical parameters
- Distinct urinary progesterone metabolite profiles during the luteal phase
- Promoter methylation levels of RASSF1 and ATIC genes are associated with lung cancer in Iranian patients
- Population status of selenium in Colombia and associated factors: a cross-sectional study
- Bambusa vulgaris leaves reverse mitochondria dysfunction in diabetic rats through modulation of mitochondria biogenic genes
- Increased expression of androgen receptor and PSA genes in LNCaP (prostate cancer) cell line due to high concentrations of EGCG, an active ingredient in green tea
- The effects of endurance exercise and metformin on memory impairment caused by diabetes
- Exercise modulation in inflammation and metabolic hormonal disorders of COVID-19 to decrease risk factors in coronary heart disease
- The effect of co-administration of artemisinin and N-acetyl cysteine on antioxidant status, spermatological parameters and histopathology of testis in adult male mice
- Case Report
- Unilateral ovarian agenesis with ipsilateral tubal presence – report of a case
- Review Articles
- Brown adipose tissue as an endocrine organ: updates on the emerging role of batokines
- Zuranolone and its role in treating major depressive disorder: a narrative review
Articles in the same Issue
- Frontmatter
- Letter to the Editor
- The role of gut microbiota in etiopathogenesis of long COVID syndrome
- Original Articles
- Risk factors and inflammatory markers in acute coronary syndrome-ST elevation myocardial infarction (STEMI)
- Association of pro-inflammatory cytokines, inflammatory proteins with atherosclerosis index in obese male subjects
- Exploration of meteorin-like peptide (metrnl) predictors in type 2 diabetic patients: the potential role of irisin, and other biochemical parameters
- Distinct urinary progesterone metabolite profiles during the luteal phase
- Promoter methylation levels of RASSF1 and ATIC genes are associated with lung cancer in Iranian patients
- Population status of selenium in Colombia and associated factors: a cross-sectional study
- Bambusa vulgaris leaves reverse mitochondria dysfunction in diabetic rats through modulation of mitochondria biogenic genes
- Increased expression of androgen receptor and PSA genes in LNCaP (prostate cancer) cell line due to high concentrations of EGCG, an active ingredient in green tea
- The effects of endurance exercise and metformin on memory impairment caused by diabetes
- Exercise modulation in inflammation and metabolic hormonal disorders of COVID-19 to decrease risk factors in coronary heart disease
- The effect of co-administration of artemisinin and N-acetyl cysteine on antioxidant status, spermatological parameters and histopathology of testis in adult male mice
- Case Report
- Unilateral ovarian agenesis with ipsilateral tubal presence – report of a case
- Review Articles
- Brown adipose tissue as an endocrine organ: updates on the emerging role of batokines
- Zuranolone and its role in treating major depressive disorder: a narrative review