A comparative study of the antidiabetic effect of two training protocols in streptozotocin-nicotinamide diabetic rats
-
Mohammad Bayat
, Mona Alaee , Ahmad Akbari , Mehdi Sadegh , Seied Amirhossein Latifi , Mohammad Parastesh , Mehdi Salehi , Hadi Karami and Jamal Amri
Abstract
Background
Physical inactivity is the major risk factor for type 2 diabetes (T2D). The present study was conducted to investigate the effects of resistance training and endurance training on diabetic-related metabolic parameters in diabetic rats.
Materials and methods
Twenty-four male Wistar rats were randomly assigned to four groups of six rats each: control group (C), diabetic group (D), resistance training group (RES) and endurance training group (END). T2D was induced intraperitoneally using nicotinamide (120 mg/kg) and streptozotocin (STZ, 65 mg/kg). The training period was 70 days. The irisin, betatrophin, insulin, fasting blood glucose (FBG) and lipid profiles were measured in the serum of all rats.
Results
Diabetes significantly increased serum levels of FBG (p < 0.001), which were decreased significantly after the administration of training (p < 0.001). Training administration had a significant effect in normalizing serum lipid profiles (p < 0.001) and it was shown to increase the serum levels of irisin, betatrophin (p < 0.001) and insulin (END: p < 0.001 and resistance training: p < 0.05). It was also found that the endurance training was more effective in improving this parameters when compared with resistance training (p < 0.05). In addition, the irisin revealed a significant positive association with betatrophin (END: p < 0.01 and resistance training: p < 0.05) and insulin (END: p < 0.01 and RES: p < 0.05) values in diabetic groups.
Conclusion
This study demonstrated that endurance training was more effective in diabetic related metabolic derangement compared with resistance training. This effect is probably due to better regulation of irisin, betatrophin and insulin relative to resistance training.
Author statement
Research funding: Authors state no funding involved.
Conflict of interest: Authors state no conflict of interest.
Informed consent: Not applicable.
Ethical approval: Animal procedures were carried out considering the Guide for the Care and Use of Laboratory that approved by the Committee on Animal Research of Arak University of Medical Sciences. The grant number was 535.
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Articles in the same Issue
- Letters to the Editor
- Androgen-driven COVID-19 infection – is testosterone an enemy or a friend?
- Tumor necrosis factor-α gene-1031T/C promoter polymorphism and endometriosis
- Original Articles
- Serum FGF-21 and FGF-23 in association with gestational diabetes: a longitudinal case-control study
- Neutrophil and monocyte ratios to high-density lipoprotein-cholesterol and adiponectin as biomarkers of nascent metabolic syndrome
- Predicting long-term cardiovascular outcomes of patients with acute myocardial infarction using soluble ST2
- Anti-inflammatory activity of emu oil-based nanofibrous scaffold through downregulation of IL-1, IL-6, and TNF-α pro-inflammatory cytokines
- A comparative study of the antidiabetic effect of two training protocols in streptozotocin-nicotinamide diabetic rats
- Gonadotrophins modulate cell death-related genes expression in human endometrium
- Exploring the activity of the enzyme 11β-hydroxylase in the polycystic ovary syndrome
- The effects of follicle-stimulating hormone receptor (FSHR) -29 and Ser680Asn polymorphisms in IVF/ICSI
- Diagnostic value of the candidate microRNAs in thyroid fine-needle aspiration biopsy (FNAB) samples
- Investigation of the role of β-TrCP in growth hormone transduction defect (GHTD)
- High-intensity interval training with long duration intervals is more effective than short duration intervals for improving glycolytic capacity in the rats’ gastrocnemius muscle
- The effects of circuit resistance training on plasma progranulin level, insulin resistance and body composition in obese men
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