Abstract
Synthesis of new efficient compounds is becoming urgent due to the resistance of organisms to drugs. Salen derivatives have interesting therapeutic and industrial applications. A coumarin based derivative of salen, 7-hydroxy-8-((E)-((2-((E)-((7-hydroxy-5-methyl-2-oxo-3,8a-dihydro-2H-chromen-8-yl)methylene)amino)-4-methylphenyl)imino)methyl)-5-methyl-2H-chromen-2-one (L), and its copper complex, CuL, have been synthesized and characterized. Antibacterial and antioxidant activity of these compounds have been evaluated and electronic, optical and molecular properties have been calculated using density functional theory (DFT) with B3LYP. The results were correlated with the biological activity and reactivity of the compounds. Experimental and theoretical calculations indicate that the studied copper complex has the potential to function as a drug. © 2016 Institute of Chemistry, Slovak Academy of Sciences
Acknowledgements
The authors are grateful the University Grants Commission (UGC) for financial support. One of the authors (SC) is thankful to the UGC for the grant Project Fellowship under the Major Research Project Scheme (F. No. 42-380/2013(SR)).
Supplementary data
Supplementary data associated with this article can be found in the online version of this paper (DOI: 10.1515/chempap-2016-0083).
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© 2016 Institute of Chemistry, Slovak Academy of Sciences
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