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Synthesis and antibacterial evaluation of novel Schiff base derivatives containing 4(3H)-quinazolinone moiety

  • Mei-Hang Chen EMAIL logo , Xiao-Bing Wang , Bang-Cheng Tang and Xun Zhang
Published/Copyright: July 19, 2016
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Abstract

A series of novel Schiff base derivatives containing 4(3H)-quinazolinone moiety were synthesised and their antibacterial activities against tobacco and tomato bacterial wilts evaluated in vitro. Out of the synthesised compounds, 5g, 5j, 5n, 5m and 5p exhibited excellent antibacterial activities against tobacco bacterial wilt, with half maximal effective concentrations (EC50): 160.34, 158.03, 125.94, 148.09 and 133.67 (all in μg mL−1), respectively, which were better than the EC50 of thiodiazole–copper (216.70 μg mL−1). Compounds 5j, 5n and 5o also showed good antibacterial activities against tomato bacterial wilt, with EC50 of 95.20, 90.03 and 83.21 (all in μg mL−1) respectively, which were better than the EC50of thiodiazole–copper (99.80 μg mL−1). These compounds may prove to be useful as potential antibacterial agents.

Acknowledgements

This work was financially supported by the opening foundation of the key laboratory of green pesticide and agricultural bioengineering, Ministry of Education, Guizhou University (no. 2010GDGP0105), Science and Technology Foundation of Guizhou Province (no. [2011]2080), and Natural Science Foundation of Guizhou Province Education (no. 2010079).

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Received: 2015-12-2
Revised: 2016-3-31
Accepted: 2016-4-16
Published Online: 2016-7-19
Published in Print: 2016-11-1

© 2016 Institute of Chemistry, Slovak Academy of Sciences

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