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Solvent-free synthesis of 6-unsubstituted dihydropyrimidinones using 2-pyrrolidonium bisulphate as efficient catalyst

  • Heshmatollah Alinezhad EMAIL logo , Mahmood Tajbakhsh , Mahboobeh Zare and Mahbooeh Mousavi
Published/Copyright: May 10, 2016
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Abstract

A one-pot three-component Biginelli-like reaction of enaminones, aldehydes with urea/thiourea in the presence of 2-pyrrolidonium bisulphate as an acidic ionic liquid catalyst for the preparation of 6-unsubstituted dihydropyrimidinones is described. The excellent yield, short reaction time, simple procedure and avoidance of the use of organic solvents are some advantages of this method.

Acknowledgements

The authors wish to acknowledge the financial support received from the University of Mazandaran Research Council.

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Received: 2015-8-5
Revised: 2015-12-25
Accepted: 2016-1-13
Published Online: 2016-5-10
Published in Print: 2016-8-1

© Institute of Chemistry, Slovak Academy of Sciences

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