Investigation of salicylatocopper complexes in the presence of a nitrogen donor ligand is a growing research area due to the interesting mimetic activities of such complexes. Here, three X-salicylatocopper (where X = 3-methyl, or 4-methoxy) complexes with three different N-donor ligands, [Cu(μ-menia)(3-Mesal)2(menia)(H2O)]2 (I), Cu(3-Mesal)2(denia)2(H2O)2 (II), Cu(4-MeOsal)2(2-pyme)2 (III), are presented (where 3-Mesal = 3-methysalicylate, 4-MeOsal = 4-methoxysalicylate, menia = N-methylnicotinamide, 2-pyme = 2-pyridylmethanol). The complexes were characterized by elemental analysis, IR and UV-VIS spectrophotometry. Cyclic voltammetry and the superoxide dismutase activity of the prepared complexes in solution were measured and the complexes were characterized by means of the inhibition concentration IC50. In addition, the superoxide dismutase (SOD) activity of these complexes was compared with those of the parent ligand copper acetate, native SOD enzyme, and the related copper complexes containing non-steroidal anti-inflammatory drugs. The resulting SOD activity was correlated to the composition, structure and redox stability of the prepared complexes. The best value of the inhibition concentration was found for complex I (IC50 = 2.24 μM), which classifies this complex into a group of good superoxide scavengers.
‡Presented at the XXV. International Conference on Coordination and Bioinorganic Chemistry, Smolenice, Slovakia, 31 May–5 June 2015.
Acknowledgements.
Slovak grant agencies (VEGA 1/0388/14, VEGA 1/0051/13, APVV-0014-11) are acknowledged for financial support.
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© 2015 Institute of Chemistry, Slovak Academy of Sciences
Articles in the same Issue
- Original Paper
- Mononuclear and heterodinuclear phenanthrolinedione complexes of d- and f-block elements‡
- Original Paper
- New heteroscorpionate lanthanide complexes for ring-opening polymerisation of ɛ-caprolactone and rac-lactide‡
- Original Paper
- EPR on bis(1,2-dithiosquarato)cuprate(II) in the bis(1,2-dithiosquarato)nickelate(II) host lattice – structure and spectroscopy‡
- Review
- Electric fields in zeolites: fundamental features and environmental implications‡
- Short Communication
- Mononuclear cobalt(III) complexes with N-salicylidene-2-hydroxy-5-bromobenzylamine and N-salicylidene-2-hydroxy-5-chlorobenzylamine‡
- Original Paper
- Nickel(II) complex with 1,4,7-tris(2-aminoethyl)-1,4,7-triazacyclononane‡
- Original Paper
- SOD mimetic activity of salicylatocopper complexes‡
- Original Paper
- Copper oxalate complexes: synthesis and structural characterisation‡
- Review
- Towards the development of highly active copper catalysts for atom transfer radical addition (ATRA) and polymerization (ATRP)‡
- Original Paper
- Synthesis, DFT calculations and characterisation of new mixed Pt(II) complexes with 3-thiolanespiro-5′ 1-hydantoin and 4-thio-1H-tetrahydropyranspiro-5′-hydantoin‡
- Short Communication
- Formation of coordination compounds with aniline in the interlayer space of Ca2+-, Cu2+- and Fe3+-exchanged montmorillonite‡
- Original Paper
- Self-assembly hydrogen-bonded supramolecular arrays from copper(II) halogenobenzoates with nicotinamide:Structure and EPR spectra‡
- Original Paper
- Different structural types of copper(II) furan- and thiophencarboxylates: X-ray structural, EPR, spectral and magnetic analyses‡
- Preface
- XXV. International Conference on Coordination & Bioinorganic Chemistry (25th ICCBiC), June 2015, Slovakia
Articles in the same Issue
- Original Paper
- Mononuclear and heterodinuclear phenanthrolinedione complexes of d- and f-block elements‡
- Original Paper
- New heteroscorpionate lanthanide complexes for ring-opening polymerisation of ɛ-caprolactone and rac-lactide‡
- Original Paper
- EPR on bis(1,2-dithiosquarato)cuprate(II) in the bis(1,2-dithiosquarato)nickelate(II) host lattice – structure and spectroscopy‡
- Review
- Electric fields in zeolites: fundamental features and environmental implications‡
- Short Communication
- Mononuclear cobalt(III) complexes with N-salicylidene-2-hydroxy-5-bromobenzylamine and N-salicylidene-2-hydroxy-5-chlorobenzylamine‡
- Original Paper
- Nickel(II) complex with 1,4,7-tris(2-aminoethyl)-1,4,7-triazacyclononane‡
- Original Paper
- SOD mimetic activity of salicylatocopper complexes‡
- Original Paper
- Copper oxalate complexes: synthesis and structural characterisation‡
- Review
- Towards the development of highly active copper catalysts for atom transfer radical addition (ATRA) and polymerization (ATRP)‡
- Original Paper
- Synthesis, DFT calculations and characterisation of new mixed Pt(II) complexes with 3-thiolanespiro-5′ 1-hydantoin and 4-thio-1H-tetrahydropyranspiro-5′-hydantoin‡
- Short Communication
- Formation of coordination compounds with aniline in the interlayer space of Ca2+-, Cu2+- and Fe3+-exchanged montmorillonite‡
- Original Paper
- Self-assembly hydrogen-bonded supramolecular arrays from copper(II) halogenobenzoates with nicotinamide:Structure and EPR spectra‡
- Original Paper
- Different structural types of copper(II) furan- and thiophencarboxylates: X-ray structural, EPR, spectral and magnetic analyses‡
- Preface
- XXV. International Conference on Coordination & Bioinorganic Chemistry (25th ICCBiC), June 2015, Slovakia