Received: 2025-07-09
Accepted: 2025-09-14
Published Online: 2025-09-25
Published in Print: 2026-02-24
© 2025 Walter de Gruyter GmbH, Berlin/Boston
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Articles in the same Issue
- Frontmatter
- Editorial
- The European Health Data Space: challenges and opportunities for laboratory medicine
- Review
- Saliva sampling matters for salivary diagnostics of viral infections
- Opinion Papers
- Mass spectrometry based precision diagnostics: on the cusp of selective testing
- Supporting trend detection in the cumulative display of electronic laboratory reports from multiple laboratories while preserving measurement provenance
- Secondary use of external quality assessment data – estimating inter-assay variation in LOINC-coded datasets
- Methodological evaluation and clinical interpretation of hs-cTnI and hs-cTnT variations: a reappraisal
- Point of care testing of biochemical markers for monitoring astronauts during long duration missions in deep space
- EFLM Paper
- Strategy of Laboratory Medicine – EFLM Vision
- Guidelines and Recommendations
- Recommendations for the study of monoclonal gammopathies in the clinical laboratory. A consensus of the Spanish Society of Laboratory Medicine and the Spanish Society of Hematology and Hemotherapy. Part III: Clinical and analytical recommendations for the study of monoclonal gammopathies by MALDI-TOF mass spectrometry
- Genetics and Molecular Diagnostics
- Optimization and comparison of genomic DNA extraction from whole blood collected in PAXgene blood RNA tube using automated platforms
- Small-scale external quality assessment of methylated SHOX2 and RASSF1A detection in China: findings from 2023–2024
- General Clinical Chemistry and Laboratory Medicine
- Development and validation of a machine learning model for accurate detection of wrong blood in tube errors in hospitalized patients
- Short- and medium-term pre-analytical stability of human serum insulin-like growth factor-1
- Creatinine measurement from finger stick dried blood spots with a routine chemistry analyzer for estimation of GFR
- Towards a global framework of entrustable professional activities for undergraduate clinical laboratory interns: a competency-based approach
- Spot urine is a suitable matrix for measurement of copeptin
- Reference Values and Biological Variations
- Use of indirect methods and machine learning algorithms for the estimation of reference intervals, taking cortisol measurements as an example
- ReferenceRangeR: a novel tool designed to facilitate reference interval estimation and verification
- VeRUS: verification of reference intervals based on the uncertainty of sampling
- Hematology and Coagulation
- Hemolysis index. Can we uncritically trust manufacturer declarations?
- Cancer Diagnostics
- Thresholds adjustments and impact on clinical performance of three FIT assays in a colorectal cancer screening program
- A robust ddPCR assay for the absolute quantification of miR-192-5p in hepatocellular carcinoma liquid biopsies
- Pro-gastrin releasing peptide as a tumor marker of medullary thyroid carcinoma: a comparative bivariate meta-analysis
- Infectious Diseases
- Prognostic utility of serial procalcitonin measurements in ICU sepsis: a laboratory-led modelling approach in a resource-limited setting procalcitonin modelling for sepsis mortality in a low-resource ICU
- Letters to the Editor
- Biological variation of serum transthyretin concentrations
- Pitfalls of immunoassays for diagnosis of hypoglycemia of undetermined etiology
- Cross reactivity of endogenous and exogenous 25-hydroxyvitamin D2 in commercial vitamin D assays; an evaluation using the Dutch external quality assessment scheme
- Interference with immunofixation in a dabigatran-overdosed patient treated with idarucizumab: beware of a diagnostic pitfall
- Potential savings of two practical interventions on vitamin D ordering practices at a large academic medical center
- Familial erythrocytosis and phenotypic heterogeneity associated with different defects in alpha globin genes: a significant new case of Hb Wroclaw (α88(F9) Ala>Glu; HBA1: c.266C>A)
- ROTEM-guided diagnostic pathway in a centralized Laboratory Medicine setting: an organizational report
Keywords for this article
immunofixation electrophoresis;
paraprotein;
idarucizumab;
dabigatran;
interference
Articles in the same Issue
- Frontmatter
- Editorial
- The European Health Data Space: challenges and opportunities for laboratory medicine
- Review
- Saliva sampling matters for salivary diagnostics of viral infections
- Opinion Papers
- Mass spectrometry based precision diagnostics: on the cusp of selective testing
- Supporting trend detection in the cumulative display of electronic laboratory reports from multiple laboratories while preserving measurement provenance
- Secondary use of external quality assessment data – estimating inter-assay variation in LOINC-coded datasets
- Methodological evaluation and clinical interpretation of hs-cTnI and hs-cTnT variations: a reappraisal
- Point of care testing of biochemical markers for monitoring astronauts during long duration missions in deep space
- EFLM Paper
- Strategy of Laboratory Medicine – EFLM Vision
- Guidelines and Recommendations
- Recommendations for the study of monoclonal gammopathies in the clinical laboratory. A consensus of the Spanish Society of Laboratory Medicine and the Spanish Society of Hematology and Hemotherapy. Part III: Clinical and analytical recommendations for the study of monoclonal gammopathies by MALDI-TOF mass spectrometry
- Genetics and Molecular Diagnostics
- Optimization and comparison of genomic DNA extraction from whole blood collected in PAXgene blood RNA tube using automated platforms
- Small-scale external quality assessment of methylated SHOX2 and RASSF1A detection in China: findings from 2023–2024
- General Clinical Chemistry and Laboratory Medicine
- Development and validation of a machine learning model for accurate detection of wrong blood in tube errors in hospitalized patients
- Short- and medium-term pre-analytical stability of human serum insulin-like growth factor-1
- Creatinine measurement from finger stick dried blood spots with a routine chemistry analyzer for estimation of GFR
- Towards a global framework of entrustable professional activities for undergraduate clinical laboratory interns: a competency-based approach
- Spot urine is a suitable matrix for measurement of copeptin
- Reference Values and Biological Variations
- Use of indirect methods and machine learning algorithms for the estimation of reference intervals, taking cortisol measurements as an example
- ReferenceRangeR: a novel tool designed to facilitate reference interval estimation and verification
- VeRUS: verification of reference intervals based on the uncertainty of sampling
- Hematology and Coagulation
- Hemolysis index. Can we uncritically trust manufacturer declarations?
- Cancer Diagnostics
- Thresholds adjustments and impact on clinical performance of three FIT assays in a colorectal cancer screening program
- A robust ddPCR assay for the absolute quantification of miR-192-5p in hepatocellular carcinoma liquid biopsies
- Pro-gastrin releasing peptide as a tumor marker of medullary thyroid carcinoma: a comparative bivariate meta-analysis
- Infectious Diseases
- Prognostic utility of serial procalcitonin measurements in ICU sepsis: a laboratory-led modelling approach in a resource-limited setting procalcitonin modelling for sepsis mortality in a low-resource ICU
- Letters to the Editor
- Biological variation of serum transthyretin concentrations
- Pitfalls of immunoassays for diagnosis of hypoglycemia of undetermined etiology
- Cross reactivity of endogenous and exogenous 25-hydroxyvitamin D2 in commercial vitamin D assays; an evaluation using the Dutch external quality assessment scheme
- Interference with immunofixation in a dabigatran-overdosed patient treated with idarucizumab: beware of a diagnostic pitfall
- Potential savings of two practical interventions on vitamin D ordering practices at a large academic medical center
- Familial erythrocytosis and phenotypic heterogeneity associated with different defects in alpha globin genes: a significant new case of Hb Wroclaw (α88(F9) Ala>Glu; HBA1: c.266C>A)
- ROTEM-guided diagnostic pathway in a centralized Laboratory Medicine setting: an organizational report