ABO blood group and von Willebrand factor: biological implications
-
Massimo Franchini
,
Silvia Crestani
Abstract
ABO blood group antigens are complex carbohydrate molecules expressed on the surface of red blood cells and a variety of human cells and tissues. It is well known that ABO blood type exerts a profound influence on hemostasis, being a major determinant of von Willebrand factor (VWF), and consequently factor VIII, plasma levels. In this review, we will focus on the molecular mechanisms underlying the interaction between ABO blood group and VWF in normal and pathological conditions.
Conflict of interest statement
Authors’ conflict of interest disclosure: The authors stated that there are no conflicts of interest regarding the publication of this article.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
References
1. Franchini M, Liumbruno GM. ABO blood group: old dogma, new perspectives. Clin Chem Lab Med 2013;51:1545–53.10.1515/cclm-2013-0168Suche in Google Scholar PubMed
2. Storry JR, Olsson ML. The ABO blood group system revisited: a review and update. Immunohematology 2009;25:48–59.10.21307/immunohematology-2019-231Suche in Google Scholar
3. Liumbruno GM, Franchini M. Beyond immunohematology: the role of the ABO blood group in human diseases. Blood Transfus 2013;11:491–9.Suche in Google Scholar
4. Franchini M, Favaloro EJ, Targher G, Lippi G. ABO blood group, hypercoagulability, and cardiovascular and cancer risk. Crit Rev Clin Lab Sci 2012;49:137–49.10.3109/10408363.2012.708647Suche in Google Scholar PubMed
5. Anstee DJ. The relationship between blood groups and disease. Blood 2010;115:4635–43.10.1182/blood-2010-01-261859Suche in Google Scholar PubMed
6. Wu O, Bayoumi N, Vickers MA, Clark P. ABO(H) blood groups and vascular disease: a systematic review and meta-analysis. J Thromb Haemost 2008;6:62–9.10.1111/j.1538-7836.2007.02818.xSuche in Google Scholar PubMed
7. Dentali F, Sironi AP, Ageno W, Turato S, Bonfanti C, Frattini F, et al. Non-O blood type is the commonest genetic risk factor for VTE: results from a meta-analysis of the literature. Semin Thromb Hemost 2012;38:535–48.10.1055/s-0032-1315758Suche in Google Scholar PubMed
8. Franchini M, Makris M. Non-O blood group: an important genetic risk factor for venous thromboembolism. Blood Transfus 2013;11:164–5.Suche in Google Scholar
9. Dentali F, Sironi AP, Ageno W, Crestani S, Franchini M. ABO blood group and vascular disease: an update. Semin Thromb Hemost 2014;40:49–59.Suche in Google Scholar
10. Moeller A, Weippert-Kretschmer M, Prinz H, Kretschmer V. Influence of ABO blood groups on primary hemostasis. Transfusion 2001;41:56–60.10.1046/j.1537-2995.2001.41010056.xSuche in Google Scholar PubMed
11. O’Donnell JS, Lasffan MA. The relationship between ABO histo-blood group, factor VIII and von Willebrand factor. Transfus Med 2001;11:343–51.10.1046/j.1365-3148.2001.00315.xSuche in Google Scholar PubMed
12. Gill JC, Endres-Brooks J, Bauer PJ, Marks WJ, Montgomery RR. The effect of ABO blood group on the diagnosis of von Willebrand disease. Blood 1987;69:1691–5.10.1182/blood.V69.6.1691.1691Suche in Google Scholar
13. Jenkins PV, O’Donnell JS. ABO blood group determines plasma von Willebrand factor levels: a biologic function after all? Transfusion 2006;46:1836–44.10.1111/j.1537-2995.2006.00975.xSuche in Google Scholar PubMed
14. Casari C, Lenting PJ, Wohner N, Christophe OD, Denis CV. Clearance of von Willebrand factor. J Thromb Haemost 2013;11 (Suppl 1):202–11.10.1111/jth.12226Suche in Google Scholar PubMed
15. Preston RJ, Rawley O, Gleeson EM, O’Donnell JS. Elucidating the role of carbohydrate determinants in regulating hemostasis: insights and opportunities. Blood 2013;121:3801–10.10.1182/blood-2012-10-415000Suche in Google Scholar PubMed
16. Davies JA, Collins PW, Hathaway LS, Bowen DJ. von Willebrand factor: evidence for variable clearance in vivo according to Y/C1584 phenotype and ABO blood group. J Thromb Haemost 2008;6:97–103.10.1111/j.1538-7836.2007.02809.xSuche in Google Scholar PubMed
17. Gallinaro L, Cattini MG, Sztukowska M, Padrini R, Sartorello F, Pontara E, et al. A shorter von Willebrand factor survival in O blood group subjects explains how ABO determinants influence plasma von Willebrand factor. Blood 2008;111:3540–5.10.1182/blood-2007-11-122945Suche in Google Scholar PubMed
18. Vlot AJ, Mauser-Bunschoten EP, Zarkova AG, Haan E, Kruitwagen CL, Sixma JJ, et al. The half-life of infused factor VIII is shorter in hemophilic patients with blood group O than in those with blood group A. Thromb Haemost 2000;83:65–9.10.1055/s-0037-1613759Suche in Google Scholar
19. Rastegarlari G, Pegon JN, Casari C, Odouard S, Navarrete AM, Saint-Lu N, et al. Macrophage LRP1 contributes to the clearance of von Willebrand factor. Blood 2012;119:2126–34.10.1182/blood-2011-08-373605Suche in Google Scholar PubMed
20. Bowen DJ. An influence of ABO blood group on the rate of proteolysis of von Willebrand factor by ADAMTS13. J Thromb Haemost 2003;1:33–40.10.1046/j.1538-7836.2003.00007.xSuche in Google Scholar PubMed
21. O’Donnell JS, McKinnon TA, Crawley JT, Lane DA, Laffan MA. Bombay phenotype is associated with reduced plasma-VWF levels and an increased susceptibility to ADAMTS13 proteolysis. Blood 2005;106:1988–91.10.1182/blood-2005-02-0792Suche in Google Scholar PubMed
22. McKinnon TA, Chion AC, Millington AJ, Lane DA, Laffan MA. N-linked glycosylation of VWF modulates its interaction with ADAMTS13. Blood 2008;111:3042–9.10.1182/blood-2007-06-095042Suche in Google Scholar PubMed
23. McGrath RT, van den Biggelaar M, Byrne B, O’Sullivan JM, Rawley O, O’Kennedy R, et al. Altered glycosylation of platelet-derived von Willebrand factor confers resistance to ADAMTS13 proteolysis. Blood 2013;122:4107–10.10.1182/blood-2013-04-496851Suche in Google Scholar PubMed
24. McGrath RT, McKinnon TA, Byrne B, O’Kennedy R, Terraube V, McRae E, et al. Expression of terminal alpha2-6-linked sialic acid on von Willebrand factor specifically enhances proteolysis by ADAMTS13. Blood 2010;115:2666–73.10.1182/blood-2009-09-241547Suche in Google Scholar
25. McGrath RT, McRae E, Smith OP, O’Donnell JS. Platelet von Willebrand factor – structure, function and biological importance. Br J Haematol 2010;148:834–43.10.1111/j.1365-2141.2009.08052.xSuche in Google Scholar
26. McKinnon TA, Goode EC, Birdsey GM, Nowak AA, Chan AC, Lane DA, et al. Specific N-linked glycosylation sites modulate synthesis and secretion of von Willebrand factor. Blood 2010;116:640–8.10.1182/blood-2010-02-267450Suche in Google Scholar
27. He M, Wolpin B, Rexrode K, Manson JE, Rimm E, Hu FB, et al. ABO blood group and risk of coronary heart disease in two prospective cohort studies. Arterioscler Thromb Vasc Biol 2012;32:2314–20.10.1161/ATVBAHA.112.248757Suche in Google Scholar
28. Koster T, Blann AD, Briët E, Vandenbroucke JP, Rosendaal FR. Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis. Lancet 1995;345:152–5.10.1016/S0140-6736(95)90166-3Suche in Google Scholar
29. Reilly MP, Li M, He J, Ferguson JF, Stylianou IM, Mehta NN, et al. Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies. Lancet 2011;377:383–92.10.1016/S0140-6736(10)61996-4Suche in Google Scholar
30. Sramek A, Bucciarelli P, Federici AB, Mannucci PM, De Rosa V, Castaman G, et al. Patients with type 3 severe von Willebrand disease are not protected against atherosclerosis: results from a multicenter study in 47 patients. Circulation 2004;109:740–4.10.1161/01.CIR.0000112567.53841.10Suche in Google Scholar PubMed
31. James PD, Notley C, Hegadorn C, Leggo J, Tuttle A, Tinlin S, et al. The mutational spectrum of type 1 von Willebrand disease: results from a Canadian cohort study. Blood 2007;109:145–54.10.1182/blood-2006-05-021105Suche in Google Scholar
32. Goodeve A, Eikenboom J, Castaman G, Rodeghiero F, Federici AB, Batlle J, et al. Phenotype and genotype of a cohort of families historically diagnosed with type 1 von Willebrand disease in the European study, Molecular and Clinical Markers for the Diagnosis and Management of Type 1 von Willebrand Disease (MCMDM-1VWD). Blood 2007;109:112–21.10.1182/blood-2006-05-020784Suche in Google Scholar PubMed
33. Castaman G, Eikenboom JC. ABO blood group also influences the von Willebrand factor (VWF) antigen level in heterozygous carriers of VWF null alleles, type 2N mutation Arg854GIn, and the missense mutation Cys2362Phe. Blood 2002;100:1927–8.10.1182/blood-2002-04-1168Suche in Google Scholar PubMed
34. Davies JA, Collins PW, Hathaway LS, Bowen DJ. Effect of von Willebrand factor Y/C1584 on in vivo protein level and function and interaction with ABO blood group. Blood 2007;109:2840–6.10.1182/blood-2006-07-035105Suche in Google Scholar PubMed
35. Millar CM, Riddell AF, Brown SA, Starke R, Mackie I, Bowen DJ, et al. Survival of von Willebrand factor released following DDAVP in a type 1 von Willebrand disease cohort: influence of glycosylation, proteolysis and gene mutations. Thromb Haemost 2008;99:916–24.10.1160/TH07-09-0565Suche in Google Scholar PubMed
36. Castaman G, Rodeghiero F. No influence of blood group on the responsiveness to desmopressin in type I “platelet normal” von Willebrand’s disease. Thromb Haemost 1995;73:551–2.10.1055/s-0038-1653816Suche in Google Scholar
37. Castaman G, Tosetto A, Eikenboom JC, Rodeghiero F. Blood group significantly influences von Willebrand factor increase and half-life after desmopressin in von Willebrand disease Vicenza. J Thromb Haemost 2010;8:2078–80.10.1111/j.1538-7836.2010.03957.xSuche in Google Scholar PubMed
©2014 by De Gruyter
Artikel in diesem Heft
- Frontmatter
- Editorial
- Red blood cell distribution width (RDW) and human pathology. One size fits all
- Reviews
- LC-MS candidate reference methods for the harmonisation of parathyroid hormone (PTH) measurement: a review of recent developments and future considerations
- C-reactive protein and migraine. Facts or speculations?
- Mini Review
- ABO blood group and von Willebrand factor: biological implications
- Genetics and Molecular Diagnostics
- Lactase persistence genotyping: rapid detection of seven sequence variants in a single tube with melting curve analyses
- General Clinical Chemistry and Laboratory Medicine
- The 3rd International Standard for serum IgE: international collaborative study to evaluate a candidate preparation
- Improving CardioCheck PA analytical performance: three-year study
- Serum copeptin level predicts a rapid decrease of overhydration after kidney transplantation
- Thyroid function and thyroid autoimmunity in apparently healthy pregnant and non-pregnant Mexican women
- Serum and follicular fluid fetuin-A in women undergoing in vitro fertilization
- Value of reelin for assessing hepatic fibrogenesis in a group of Egyptian HCV infected patients
- IgA anticardiolipin and IgA anti-β2 glycoprotein I antibody positivity determined by fluorescence enzyme immunoassay in primary antiphospholipid syndrome
- Reference Values and Biological Variations
- Serum glucose adjusted cut-off values for normal cerebrospinal fluid/serum glucose ratio: implications for clinical practice
- Age- and gender-specific brain natriuretic peptide (BNP) reference ranges in primary care
- Cancer Diagnostics
- Clinical utility of %p2PSA and prostate health index in the detection of prostate cancer
- Clinical prognostic value of CD4+CD25+FOXP3+regulatory T cells in peripheral blood of Barcelona Clinic Liver Cancer (BCLC) stage B hepatocellular carcinoma patients
- Increased expression of carbonic anhydrase IX in oral submucous fibrosis and oral squamous cell carcinoma
- Cardiovascular Diseases
- Ideal cardiovascular health behaviors and factors and high sensitivity C-reactive protein: the Kailuan cross-sectional study in Chinese
- Letters to the Editor
- Red cell distribution width predicts chronic thromboembolic pulmonary hypertension in patients with acute pulmonary embolism in a long-term follow-up
- Red blood cell distribution width is significantly associated with aging and gender
- Red blood cell distribution width: a potential prognostic index for liver disease?
- Serum folate and vitamin B12: does light really matter?
- Thalassemia diagnosis in a blood donor from a unique trimorphic red blood cell population observed in the recipient
- A preliminary study on serum proteomics in fibromyalgia syndrome
- First study of angiotensin converting enzyme in cystic fibrosis Tunisian patients
- FlashFISH™: a novel technique for rapid diagnosis of aneuploidies in dysmorphic neonates
- Determination of the amniotic fluid lecithin/sphingomyelin ratio using a pipette tip column with a cation-exchange resin and mass spectrometry
- Congress Abstracts
- 57th National Congress of the Hungarian Society of Laboratory Medicine
Artikel in diesem Heft
- Frontmatter
- Editorial
- Red blood cell distribution width (RDW) and human pathology. One size fits all
- Reviews
- LC-MS candidate reference methods for the harmonisation of parathyroid hormone (PTH) measurement: a review of recent developments and future considerations
- C-reactive protein and migraine. Facts or speculations?
- Mini Review
- ABO blood group and von Willebrand factor: biological implications
- Genetics and Molecular Diagnostics
- Lactase persistence genotyping: rapid detection of seven sequence variants in a single tube with melting curve analyses
- General Clinical Chemistry and Laboratory Medicine
- The 3rd International Standard for serum IgE: international collaborative study to evaluate a candidate preparation
- Improving CardioCheck PA analytical performance: three-year study
- Serum copeptin level predicts a rapid decrease of overhydration after kidney transplantation
- Thyroid function and thyroid autoimmunity in apparently healthy pregnant and non-pregnant Mexican women
- Serum and follicular fluid fetuin-A in women undergoing in vitro fertilization
- Value of reelin for assessing hepatic fibrogenesis in a group of Egyptian HCV infected patients
- IgA anticardiolipin and IgA anti-β2 glycoprotein I antibody positivity determined by fluorescence enzyme immunoassay in primary antiphospholipid syndrome
- Reference Values and Biological Variations
- Serum glucose adjusted cut-off values for normal cerebrospinal fluid/serum glucose ratio: implications for clinical practice
- Age- and gender-specific brain natriuretic peptide (BNP) reference ranges in primary care
- Cancer Diagnostics
- Clinical utility of %p2PSA and prostate health index in the detection of prostate cancer
- Clinical prognostic value of CD4+CD25+FOXP3+regulatory T cells in peripheral blood of Barcelona Clinic Liver Cancer (BCLC) stage B hepatocellular carcinoma patients
- Increased expression of carbonic anhydrase IX in oral submucous fibrosis and oral squamous cell carcinoma
- Cardiovascular Diseases
- Ideal cardiovascular health behaviors and factors and high sensitivity C-reactive protein: the Kailuan cross-sectional study in Chinese
- Letters to the Editor
- Red cell distribution width predicts chronic thromboembolic pulmonary hypertension in patients with acute pulmonary embolism in a long-term follow-up
- Red blood cell distribution width is significantly associated with aging and gender
- Red blood cell distribution width: a potential prognostic index for liver disease?
- Serum folate and vitamin B12: does light really matter?
- Thalassemia diagnosis in a blood donor from a unique trimorphic red blood cell population observed in the recipient
- A preliminary study on serum proteomics in fibromyalgia syndrome
- First study of angiotensin converting enzyme in cystic fibrosis Tunisian patients
- FlashFISH™: a novel technique for rapid diagnosis of aneuploidies in dysmorphic neonates
- Determination of the amniotic fluid lecithin/sphingomyelin ratio using a pipette tip column with a cation-exchange resin and mass spectrometry
- Congress Abstracts
- 57th National Congress of the Hungarian Society of Laboratory Medicine
