Clinical utility of %p2PSA and prostate health index in the detection of prostate cancer
-
Xavier Filella
,
Laura Foj
Abstract
Background: %p2PSA and prostate health index (phi) has shown valuable results in the detection of prostate cancer (PCa), improving the prediction of the aggressiveness of the tumor. The goal of the present study was to evaluate %p2PSA and phi in the detection of PCa, estimating their relationship with the aggressiveness of PCa.
Methods: A total of 354 patients with positive or negative prostatic biopsy were included. Prospectively, 150 were enrolled and 204 were enrolled retrospectively proceeding from our serum bank.
Results: The best performance was observed for %p2PSA and phi, obtaining an AUC of 0.723 and 0.732, respectively. The highest specificity at sensitivity around 90% was obtained for phi (27.4%). Using the cut-off of 31.94 for phi, a reduction of 19% biopsies could be obtained, while 17 PCa would have been missed, including only four patients with a Gleason score ≥7. Similarly, using a cut-off of 1.21 for %p2PSA, a reduction of 12.7% biopsies could be obtained, while 16 PCa would have been missed, including only four patients with a Gleason score ≥7. Moreover, among patients with PCa, phi (median: 69.75 vs. 48.04) and %p2PSA (median: 2.60 vs. 1.98) values are significantly higher (p<0.0001) in patients with a biopsy Gleason score ≥7.
Conclusions: Our results confirm previous evaluations, showing similar AUCs and results in sensitivity and specificity to other studies.%p2PSA and phi raise the accuracy in the detection of prostate cancer, reducing the number of unnecessary biopsies and improving the prediction of the aggressiveness of the tumor.
Acknowledgments
Reagent for measurements of tPSA, fPSA and p2PSA was furnished freely by Beckman Coulter. Study was supported by grant Emili Letang from Hospital Clínic to Dr. Foj.
Conflict of interest statement
Authors’ conflict of interest disclosure: The authors stated that there are no conflicts of interest regarding the publication of this article. Research support played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
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©2014 by De Gruyter
Artikel in diesem Heft
- Frontmatter
- Editorial
- Red blood cell distribution width (RDW) and human pathology. One size fits all
- Reviews
- LC-MS candidate reference methods for the harmonisation of parathyroid hormone (PTH) measurement: a review of recent developments and future considerations
- C-reactive protein and migraine. Facts or speculations?
- Mini Review
- ABO blood group and von Willebrand factor: biological implications
- Genetics and Molecular Diagnostics
- Lactase persistence genotyping: rapid detection of seven sequence variants in a single tube with melting curve analyses
- General Clinical Chemistry and Laboratory Medicine
- The 3rd International Standard for serum IgE: international collaborative study to evaluate a candidate preparation
- Improving CardioCheck PA analytical performance: three-year study
- Serum copeptin level predicts a rapid decrease of overhydration after kidney transplantation
- Thyroid function and thyroid autoimmunity in apparently healthy pregnant and non-pregnant Mexican women
- Serum and follicular fluid fetuin-A in women undergoing in vitro fertilization
- Value of reelin for assessing hepatic fibrogenesis in a group of Egyptian HCV infected patients
- IgA anticardiolipin and IgA anti-β2 glycoprotein I antibody positivity determined by fluorescence enzyme immunoassay in primary antiphospholipid syndrome
- Reference Values and Biological Variations
- Serum glucose adjusted cut-off values for normal cerebrospinal fluid/serum glucose ratio: implications for clinical practice
- Age- and gender-specific brain natriuretic peptide (BNP) reference ranges in primary care
- Cancer Diagnostics
- Clinical utility of %p2PSA and prostate health index in the detection of prostate cancer
- Clinical prognostic value of CD4+CD25+FOXP3+regulatory T cells in peripheral blood of Barcelona Clinic Liver Cancer (BCLC) stage B hepatocellular carcinoma patients
- Increased expression of carbonic anhydrase IX in oral submucous fibrosis and oral squamous cell carcinoma
- Cardiovascular Diseases
- Ideal cardiovascular health behaviors and factors and high sensitivity C-reactive protein: the Kailuan cross-sectional study in Chinese
- Letters to the Editor
- Red cell distribution width predicts chronic thromboembolic pulmonary hypertension in patients with acute pulmonary embolism in a long-term follow-up
- Red blood cell distribution width is significantly associated with aging and gender
- Red blood cell distribution width: a potential prognostic index for liver disease?
- Serum folate and vitamin B12: does light really matter?
- Thalassemia diagnosis in a blood donor from a unique trimorphic red blood cell population observed in the recipient
- A preliminary study on serum proteomics in fibromyalgia syndrome
- First study of angiotensin converting enzyme in cystic fibrosis Tunisian patients
- FlashFISH™: a novel technique for rapid diagnosis of aneuploidies in dysmorphic neonates
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- Congress Abstracts
- 57th National Congress of the Hungarian Society of Laboratory Medicine
Artikel in diesem Heft
- Frontmatter
- Editorial
- Red blood cell distribution width (RDW) and human pathology. One size fits all
- Reviews
- LC-MS candidate reference methods for the harmonisation of parathyroid hormone (PTH) measurement: a review of recent developments and future considerations
- C-reactive protein and migraine. Facts or speculations?
- Mini Review
- ABO blood group and von Willebrand factor: biological implications
- Genetics and Molecular Diagnostics
- Lactase persistence genotyping: rapid detection of seven sequence variants in a single tube with melting curve analyses
- General Clinical Chemistry and Laboratory Medicine
- The 3rd International Standard for serum IgE: international collaborative study to evaluate a candidate preparation
- Improving CardioCheck PA analytical performance: three-year study
- Serum copeptin level predicts a rapid decrease of overhydration after kidney transplantation
- Thyroid function and thyroid autoimmunity in apparently healthy pregnant and non-pregnant Mexican women
- Serum and follicular fluid fetuin-A in women undergoing in vitro fertilization
- Value of reelin for assessing hepatic fibrogenesis in a group of Egyptian HCV infected patients
- IgA anticardiolipin and IgA anti-β2 glycoprotein I antibody positivity determined by fluorescence enzyme immunoassay in primary antiphospholipid syndrome
- Reference Values and Biological Variations
- Serum glucose adjusted cut-off values for normal cerebrospinal fluid/serum glucose ratio: implications for clinical practice
- Age- and gender-specific brain natriuretic peptide (BNP) reference ranges in primary care
- Cancer Diagnostics
- Clinical utility of %p2PSA and prostate health index in the detection of prostate cancer
- Clinical prognostic value of CD4+CD25+FOXP3+regulatory T cells in peripheral blood of Barcelona Clinic Liver Cancer (BCLC) stage B hepatocellular carcinoma patients
- Increased expression of carbonic anhydrase IX in oral submucous fibrosis and oral squamous cell carcinoma
- Cardiovascular Diseases
- Ideal cardiovascular health behaviors and factors and high sensitivity C-reactive protein: the Kailuan cross-sectional study in Chinese
- Letters to the Editor
- Red cell distribution width predicts chronic thromboembolic pulmonary hypertension in patients with acute pulmonary embolism in a long-term follow-up
- Red blood cell distribution width is significantly associated with aging and gender
- Red blood cell distribution width: a potential prognostic index for liver disease?
- Serum folate and vitamin B12: does light really matter?
- Thalassemia diagnosis in a blood donor from a unique trimorphic red blood cell population observed in the recipient
- A preliminary study on serum proteomics in fibromyalgia syndrome
- First study of angiotensin converting enzyme in cystic fibrosis Tunisian patients
- FlashFISH™: a novel technique for rapid diagnosis of aneuploidies in dysmorphic neonates
- Determination of the amniotic fluid lecithin/sphingomyelin ratio using a pipette tip column with a cation-exchange resin and mass spectrometry
- Congress Abstracts
- 57th National Congress of the Hungarian Society of Laboratory Medicine
