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Serum copeptin level predicts a rapid decrease of overhydration after kidney transplantation

  • Aureliusz Kolonko EMAIL logo , Jerzy Chudek , Agata Kujawa-Szewieczek , Beata Czerwieńska and Andrzej Wiecek
Published/Copyright: April 3, 2014
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Clinical Chemistry and Laboratory Medicine (CCLM)
From the journal Clinical Chemistry and Laboratory Medicine (CCLM) Volume 52 Issue 9

Abstract

Background: The assessment of proper hydration status in hemodialysis patients is difficult. None of currently available markers or measures is clinically relevant. Recently, human pre-pro-vasopressin (1-164) split product [copeptin (CPP)] – a new surrogate marker of hydration status – was introduced. The aim of the study was to analyze body weight changes in the early post-transplant period in relation to serum CPP levels before kidney transplantation.

Methods: Serum CPP and NT-proBNP concentrations and osmolality were measured in 130 kidney recipients directly prior to transplantation and, additionally, in 78 of them at 14th day post-transplant. Hydration status at transplantation was calculated from the difference in the patient’s body weight before transplantation and at the discharge.

Results: During the post-transplant hospitalization, the average weight change was –1.6 kg, varying from 10.5 kg loss to weight gain of 5 kg. The overall weight loss was significantly related to pretransplant serum concentration of CPP (r=0.238), but not of NT-proBNP or osmolality. Patients with the lowest initial CPP level (first tertile) had smaller post-transplant weight loss. The early kidney graft function was unrelated to pretransplant CPP. Multivariate regression model revealed that variability of post-transplant weight loss is explained by the number of antihypertensive drugs used prior to transplantation [β=0.213 (0.049–0.377)] and pretransplant CPP values [β=0.233 (0.069–0.397)].

Conclusions: Elevated serum CPP level predicts a rapid weight loss after kidney transplantation and seems to characterize the subgroup of patients with the greatest overhydration. These results suggest the dysregulation of physiological mechanisms of CPP secretion in hemodialysis patients.

Keywords: dry weight; hemodialysis; NT-proBNP; osmolality; weight loss
Corresponding author: Aureliusz Kolonko, PhD, Department of Nephrology, Endocrinology and Metabolic Diseases, Medical University of Silesia, Francuska 20/24, 40-027 Katowice, Poland, Phone: +48 322591429, Fax: +48 322553726, E-mail:

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Received: 2014-2-8
Accepted: 2014-3-10
Published Online: 2014-4-3
Published in Print: 2014-9-1

©2014 by De Gruyter

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https://doi.org/10.1515/cclm-2014-0135
Keywords for this article
dry weight; hemodialysis; NT-proBNP; osmolality; weight loss

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. Red blood cell distribution width (RDW) and human pathology. One size fits all
  4. Reviews
  5. LC-MS candidate reference methods for the harmonisation of parathyroid hormone (PTH) measurement: a review of recent developments and future considerations
  6. C-reactive protein and migraine. Facts or speculations?
  7. Mini Review
  8. ABO blood group and von Willebrand factor: biological implications
  9. Genetics and Molecular Diagnostics
  10. Lactase persistence genotyping: rapid detection of seven sequence variants in a single tube with melting curve analyses
  11. General Clinical Chemistry and Laboratory Medicine
  12. The 3rd International Standard for serum IgE: international collaborative study to evaluate a candidate preparation
  13. Improving CardioCheck PA analytical performance: three-year study
  14. Serum copeptin level predicts a rapid decrease of overhydration after kidney transplantation
  15. Thyroid function and thyroid autoimmunity in apparently healthy pregnant and non-pregnant Mexican women
  16. Serum and follicular fluid fetuin-A in women undergoing in vitro fertilization
  17. Value of reelin for assessing hepatic fibrogenesis in a group of Egyptian HCV infected patients
  18. IgA anticardiolipin and IgA anti-β2 glycoprotein I antibody positivity determined by fluorescence enzyme immunoassay in primary antiphospholipid syndrome
  19. Reference Values and Biological Variations
  20. Serum glucose adjusted cut-off values for normal cerebrospinal fluid/serum glucose ratio: implications for clinical practice
  21. Age- and gender-specific brain natriuretic peptide (BNP) reference ranges in primary care
  22. Cancer Diagnostics
  23. Clinical utility of %p2PSA and prostate health index in the detection of prostate cancer
  24. Clinical prognostic value of CD4+CD25+FOXP3+regulatory T cells in peripheral blood of Barcelona Clinic Liver Cancer (BCLC) stage B hepatocellular carcinoma patients
  25. Increased expression of carbonic anhydrase IX in oral submucous fibrosis and oral squamous cell carcinoma
  26. Cardiovascular Diseases
  27. Ideal cardiovascular health behaviors and factors and high sensitivity C-reactive protein: the Kailuan cross-sectional study in Chinese
  28. Letters to the Editor
  29. Red cell distribution width predicts chronic thromboembolic pulmonary hypertension in patients with acute pulmonary embolism in a long-term follow-up
  30. Red blood cell distribution width is significantly associated with aging and gender
  31. Red blood cell distribution width: a potential prognostic index for liver disease?
  32. Serum folate and vitamin B12: does light really matter?
  33. Thalassemia diagnosis in a blood donor from a unique trimorphic red blood cell population observed in the recipient
  34. A preliminary study on serum proteomics in fibromyalgia syndrome
  35. First study of angiotensin converting enzyme in cystic fibrosis Tunisian patients
  36. FlashFISH™: a novel technique for rapid diagnosis of aneuploidies in dysmorphic neonates
  37. Determination of the amniotic fluid lecithin/sphingomyelin ratio using a pipette tip column with a cation-exchange resin and mass spectrometry
  38. Congress Abstracts
  39. 57th National Congress of the Hungarian Society of Laboratory Medicine
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