Startseite Comparison of serum calcitonin and procalcitonin in detecting medullary thyroid carcinoma among patients with thyroid nodules
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Comparison of serum calcitonin and procalcitonin in detecting medullary thyroid carcinoma among patients with thyroid nodules

  • Luca Giovanella EMAIL logo , Frederik A. Verburg , Mauro Imperiali , Stefano Valabrega , Pierpaolo Trimboli und Luca Ceriani
Veröffentlicht/Copyright: 25. Dezember 2012
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Clinical Chemistry and Laboratory Medicine
Aus der Zeitschrift Clinical Chemistry and Laboratory Medicine Band 51 Heft 7

Abstract

Background: To prospectively evaluate the role of procalcitonin (PCT) in detecting or excluding medullary thyroid carcinoma (MTC) among patients with thyroid nodules and increased calcitonin (CT) levels.

Methods: Fourteen of 1236 patients referred for thyroid nodules had increased serum CT >10 pg/mL. A stimulation test with pentagastrin was done and both CT and PCT were measured after stimulation. All patients underwent thyroid ultrasound, fine-needle cytology and, if indicated, surgery with histological and immunohistochemical examination of the surgical specimens.

Results: After follow-up, two MTCs were found. These two patients had basal CT >100 pg/mL and detectable (>0.1 ng/mL) PCT, with 100% sensitivity. Pentagastrin stimulated CT achieved values above 100 pg/mL in two MTCs and in other two cases with no MTC outcome (50% PPV and 83% NPV). On the contrary, all patients with no MTC had both basal and stimulated undetectable PCT (100% PPV and 100% NPV).

Conclusions: The addition of basal PCT measurement in patients with thyroid nodule(s) and increased CT may significantly improve accuracy of CT measurement without needing a PG stimulation test.

Keywords: calcitonin; medullary thyroid carcinoma; procalcitonin; thyroid nodule
Corresponding author: PD Dr med. Luca Giovanella, Department of Nuclear Medicine and Thyroid Centre, Oncology Institute of Southern Switzerland, Via Ospedale 12, 6500 Bellinzona, Switzerland, Phone: +41 91 8118672, Fax: +41 91 8118250

Conflict of interest statement

Authors’ conflict of interest disclosure: The authors stated that there are no conflicts of interest regarding the publication of this article.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

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Received: 2012-9-14
Accepted: 2012-11-29
Published Online: 2012-12-25
Published in Print: 2013-07-01

©2013 by Walter de Gruyter Berlin Boston

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https://doi.org/10.1515/cclm-2012-0610
Schlagwörter für diesen Artikel
calcitonin; medullary thyroid carcinoma; procalcitonin; thyroid nodule

Artikel in diesem Heft

  1. Masthead
  2. Masthead
  3. Editorials
  4. Biomarkers in the treatment of cancer: opportunities and pitfalls
  5. Multicenter reference intervals studies: a promising perspective for the future?
  6. Hemolysis-resistant reagent: another part of the puzzle for preventing errors in laboratory testing
  7. Review
  8. Exhaled breath condensate: a comprehensive update
  9. Mini Review
  10. Psoriasis, a new challenge for laboratory medicine
  11. Opinion Paper
  12. CA 19-9: handle with care
  13. General Clinical Chemistry and Laboratory Medicine
  14. Performance evaluation of human cytokines profiles obtained by various multiplexed-based technologies underlines a need for standardization
  15. The iron regulatory hormone hepcidin is decreased in pregnancy: a prospective longitudinal study
  16. Red blood cell distribution width is a potential prognostic index for liver disease
  17. Development of a novel, hemolysis-resistant reagent for assessment of α-amylase in biological fluids
  18. Performance of cassette-based blood gas analyzers to monitor blood glucose and lactate levels in a surgical intensive care setting
  19. Reference Values and Biological Variations
  20. The Asian project for collaborative derivation of reference intervals: (1) strategy and major results of standardized analytes
  21. The Asian project for collaborative derivation of reference intervals: (2) results of non-standardized analytes and transference of reference intervals to the participating laboratories on the basis of cross-comparison of test results
  22. Cancer Diagnostics
  23. Study of an elevated carbohydrate antigen 19-9 concentration in a large health check-up cohort in China
  24. Glycoproteomic identification of potential glycoprotein biomarkers in ovarian cancer proximal fluids
  25. Comparison of serum calcitonin and procalcitonin in detecting medullary thyroid carcinoma among patients with thyroid nodules
  26. Serum HER-2 predicts response and resistance to trastuzumab treatment in breast cancer
  27. Elevated tumor markers in patients with pulmonary alveolar proteinosis
  28. Serum carcinoembryonic antigen is associated with non-alcoholic fatty liver disease in healthy Korean non-smokers
  29. Assessment of SOX17 DNA methylation in cell free DNA from patients with operable gastric cancer. Association with prognostic variables and survival
  30. Sensitivity of CA 15-3, CEA and serum HER2 in the early detection of recurrence of breast cancer
  31. Cardiovascular Diseases
  32. Association of nucleotide-binding oligomerization domain-like receptor 3 inflammasome and adverse clinical outcomes in patients with idiopathic dilated cardiomyopathy
  33. Diabetes
  34. α1-Microglobulin/albumin ratio may improve interpretation of albuminuria in statin-treated patients
  35. Infectious Diseases
  36. The role of procalcitonin and IL-6 in discriminating between septic and non-septic causes of ALI/ARDS: a prospective observational study
  37. Letters to the Editor
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  43. A case of mistaken diagnosis of heparin-induced thrombocytopenia due to pseudothrombocytopenia
  44. Delta check: a must in the management of hyponatremia
  45. A novel cost effective algorithm for antinuclear antibody (ANA) testing in an outpatient setting
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