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Population-based pediatric reference intervals for general clinical chemistry analytes on the Abbott Architect ci8200 instrument
-
Peter Ridefelt
,
Mattias Aldrimer
Veröffentlicht/Copyright:
29. Februar 2012
Abstract
Background: Reference intervals are crucial decision-making tools aiding clinicians in differentiating between healthy and diseased populations. However, for children such values often are lacking or incomplete.
Methods: Blood samples were obtained from 692 healthy children, aged 6 months to 18 years, recruited in daycare centers and schools. Twelve common general clinical chemistry analytes were measured on the Abbott Architect ci8200 platform; sodium, potassium, chloride, calcium, albumin-adjusted calcium, phosphate, magnesium, creatinine (Jaffe and enzymatic), cystatin C, urea and uric acid.
Results: Age- and gender specific pediatric reference intervals were defined by calculating the 2.5th and 97.5th percentiles.
Conclusions: The data generated is primarily applicable to a Caucasian population when using the Abbott Architect platform, but could be used by any laboratory if validated for the local patient population.
Received: 2011-10-28
Accepted: 2012-1-27
Published Online: 2012-02-29
Published in Print: 2012-05-01
©2012 by Walter de Gruyter Berlin Boston
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- Masthead
- Masthead
- Editorials
- Reference values and the journal: why the past is now present
- Other-than-annual variations in morning determinations of uric acid
- Reviews
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- A comprehensive review of upper reference limits reported for (high-)sensitivity cardiac troponin assays: the challenges that lie ahead
- Mini Review
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- Obtaining reference intervals traceable to reference measurement systems: is it possible, who is responsible, what is the strategy?
- Analytical performance, reference values and decision limits. A need to differentiate between reference intervals and decision limits and to define analytical quality specifications
- A pragmatic proposal for permissible limits in external quality assessment schemes with a compromise between biological variation and the state of the art
- Original Articles
- Age dependence of within-subject biological variation of nine common clinical chemistry analytes
- Population-based pediatric reference intervals for general clinical chemistry analytes on the Abbott Architect ci8200 instrument
- Uric acid biorhythm, a feature of long-term variation in a clinical laboratory database
- Age-related changes in serum amino acids concentrations in healthy individuals
- Characterisation of a highly sensitive troponin I assay and its application to a cardio-healthy population
- Are the currently used reference intervals for creatine kinase (CK) reflecting the general population? The Tromsø Study
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- Trimester-specific reference intervals for haemoglobin A1c (HbA1c) in pregnancy
- The concentration of adiponectin in breast milk is related to maternal hormonal and inflammatory status during 6 months of lactation
- Age- and sex-specific reference limits for creatinine, cystatin C and the estimated glomerular filtration rate
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- Faecal haemoglobin concentrations by gender and age: implications for population-based screening for colorectal cancer
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- Reference change values for lens culinaris agglutinin-reactive α-fetoprotein and des-γ-carboxy prothrombin in patients with chronic hepatitis C
- Letters to the Editor
- Disadvantages of using biological variation data for reference change values
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- Insulin-like growth factor 1 reference intervals for a chemiluminescent enzyme immunometric assay (Immulite 2000®) in an adult Mediterranean population
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- Congress Abstracts
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Schlagwörter für diesen Artikel
biomarker;
children;
immunoassay;
pediatric;
reference interval;
reference range
Artikel in diesem Heft
- Masthead
- Masthead
- Editorials
- Reference values and the journal: why the past is now present
- Other-than-annual variations in morning determinations of uric acid
- Reviews
- Blood biochemical markers of bone turnover: pre-analytical and technical aspects of sample collection and handling
- A comprehensive review of upper reference limits reported for (high-)sensitivity cardiac troponin assays: the challenges that lie ahead
- Mini Review
- Reference change values
- Opinion Papers
- Obtaining reference intervals traceable to reference measurement systems: is it possible, who is responsible, what is the strategy?
- Analytical performance, reference values and decision limits. A need to differentiate between reference intervals and decision limits and to define analytical quality specifications
- A pragmatic proposal for permissible limits in external quality assessment schemes with a compromise between biological variation and the state of the art
- Original Articles
- Age dependence of within-subject biological variation of nine common clinical chemistry analytes
- Population-based pediatric reference intervals for general clinical chemistry analytes on the Abbott Architect ci8200 instrument
- Uric acid biorhythm, a feature of long-term variation in a clinical laboratory database
- Age-related changes in serum amino acids concentrations in healthy individuals
- Characterisation of a highly sensitive troponin I assay and its application to a cardio-healthy population
- Are the currently used reference intervals for creatine kinase (CK) reflecting the general population? The Tromsø Study
- Age-specific thyroid hormone and thyrotropin reference intervals for a pediatric and adolescent population
- Serum thyroglobulin reference values according to NACB criteria in healthy subjects with normal thyroid ultrasound
- Thyroid volume influences serum calcitonin levels in a thyroid-healthy population: results of a 3-assay, 519 subjects study
- Impact of the reference values on the clinically-relevant cut-offs. The example of cortisol testing in children
- Trimester-specific reference intervals for haemoglobin A1c (HbA1c) in pregnancy
- The concentration of adiponectin in breast milk is related to maternal hormonal and inflammatory status during 6 months of lactation
- Age- and sex-specific reference limits for creatinine, cystatin C and the estimated glomerular filtration rate
- Determination of the biological variation of S100β and lactate dehydrogenase in disease-free patients with malignant melanoma
- Reference intervals and biological variation for kallikrein 6: influence of age and renal failure
- Faecal haemoglobin concentrations by gender and age: implications for population-based screening for colorectal cancer
- Reference intervals of extended erythrocyte and reticulocyte parameters
- Haematological and iron metabolism parameters in professional cyclists during the Giro d’Italia 3-weeks stage race
- Reference change values for lens culinaris agglutinin-reactive α-fetoprotein and des-γ-carboxy prothrombin in patients with chronic hepatitis C
- Letters to the Editor
- Disadvantages of using biological variation data for reference change values
- Reference change values may need some improvement but are invaluable tools in laboratory medicine
- Insulin-like growth factor 1 reference intervals for a chemiluminescent enzyme immunometric assay (Immulite 2000®) in an adult Mediterranean population
- Reference values for new red blood cell and platelet parameters on the Abbott Diagnostics Cell-Dyn Sapphire
- Congress Abstracts
- Swiss MedLab 2012 Congress of the Swiss Union of Laboratory Medicine (SULM)
