Article
Licensed
Unlicensed
Requires Authentication
Age- and sex-specific reference limits for creatinine, cystatin C and the estimated glomerular filtration rate
-
Anke Hannemann
,
Nele Friedrich
Published/Copyright:
November 14, 2011
Abstract
Background: Early detection of patients with chronic kidney disease is of great importance. This study developed reference limits for serum creatinine and serum cystatin C concentrations and for the estimated glomerular filtration rate (eGFR) in healthy subjects from the general population aged 25–65 years.
Methods: This study defined a reference population including 985 subjects from the first follow-up of the Study of Health in Pomerania. Serum creatinine was measured with a modified kinetic Jaffé method. Serum cystatin C was measured with a nephelometric assay. The eGFR was calculated from serum creatinine according to the Cockcroft-Gault (eGFRCG) and the Modification of Diet in Renal Disease (eGFRMDRD) equation, respectively, as well as from serum cystatin C according to the formula by Larsson (eGFRLarsson). Non-parametric quantile regression was used to estimate the reference limits. For serum creatinine and serum cystatin C the 95th percentile and for eGFRCG, eGFRMDRD and eGFRLarsson the 5th percentile were selected as reference limits. All data was weighted to reflect the age- and sex-structure of the German population in 2008.
Results: The reference limits for serum creatinine (men: 1.11–1.23 mg/dL; women: 0.93–1.00 mg/dL) and serum cystatin C levels (men: 0.92–1.04 mg/L; women: 0.84–1.02 mg/L) increased with advancing age. The reference limits for eGFR decreased with increasing age (eGFRCG men: 106.0–64.7 mL/min, women 84.4–57.9 mL/min; eGFRMDRD men: 82.5–62.2 mL/min/1.73 m2, women 75.0–58.2 mL/min/1.73 m2; eGFRLarsson men: 85.5–72.9 mL/min, women 94.5–75.7 mL/min).
Conclusions: This study presents age- and sex-specific reference limits for five measures of renal function based on quantile regression models.
Keywords: creatinine; cystatin C; glomerular filtration rate; population-based study; reference limits; study of health in Pomerania
Received: 2011-8-22
Accepted: 2011-10-21
Published Online: 2011-11-14
Published in Print: 2012-05-01
©2012 by Walter de Gruyter Berlin Boston
You are currently not able to access this content.
You are currently not able to access this content.
Articles in the same Issue
- Masthead
- Masthead
- Editorials
- Reference values and the journal: why the past is now present
- Other-than-annual variations in morning determinations of uric acid
- Reviews
- Blood biochemical markers of bone turnover: pre-analytical and technical aspects of sample collection and handling
- A comprehensive review of upper reference limits reported for (high-)sensitivity cardiac troponin assays: the challenges that lie ahead
- Mini Review
- Reference change values
- Opinion Papers
- Obtaining reference intervals traceable to reference measurement systems: is it possible, who is responsible, what is the strategy?
- Analytical performance, reference values and decision limits. A need to differentiate between reference intervals and decision limits and to define analytical quality specifications
- A pragmatic proposal for permissible limits in external quality assessment schemes with a compromise between biological variation and the state of the art
- Original Articles
- Age dependence of within-subject biological variation of nine common clinical chemistry analytes
- Population-based pediatric reference intervals for general clinical chemistry analytes on the Abbott Architect ci8200 instrument
- Uric acid biorhythm, a feature of long-term variation in a clinical laboratory database
- Age-related changes in serum amino acids concentrations in healthy individuals
- Characterisation of a highly sensitive troponin I assay and its application to a cardio-healthy population
- Are the currently used reference intervals for creatine kinase (CK) reflecting the general population? The Tromsø Study
- Age-specific thyroid hormone and thyrotropin reference intervals for a pediatric and adolescent population
- Serum thyroglobulin reference values according to NACB criteria in healthy subjects with normal thyroid ultrasound
- Thyroid volume influences serum calcitonin levels in a thyroid-healthy population: results of a 3-assay, 519 subjects study
- Impact of the reference values on the clinically-relevant cut-offs. The example of cortisol testing in children
- Trimester-specific reference intervals for haemoglobin A1c (HbA1c) in pregnancy
- The concentration of adiponectin in breast milk is related to maternal hormonal and inflammatory status during 6 months of lactation
- Age- and sex-specific reference limits for creatinine, cystatin C and the estimated glomerular filtration rate
- Determination of the biological variation of S100β and lactate dehydrogenase in disease-free patients with malignant melanoma
- Reference intervals and biological variation for kallikrein 6: influence of age and renal failure
- Faecal haemoglobin concentrations by gender and age: implications for population-based screening for colorectal cancer
- Reference intervals of extended erythrocyte and reticulocyte parameters
- Haematological and iron metabolism parameters in professional cyclists during the Giro d’Italia 3-weeks stage race
- Reference change values for lens culinaris agglutinin-reactive α-fetoprotein and des-γ-carboxy prothrombin in patients with chronic hepatitis C
- Letters to the Editor
- Disadvantages of using biological variation data for reference change values
- Reference change values may need some improvement but are invaluable tools in laboratory medicine
- Insulin-like growth factor 1 reference intervals for a chemiluminescent enzyme immunometric assay (Immulite 2000®) in an adult Mediterranean population
- Reference values for new red blood cell and platelet parameters on the Abbott Diagnostics Cell-Dyn Sapphire
- Congress Abstracts
- Swiss MedLab 2012 Congress of the Swiss Union of Laboratory Medicine (SULM)
Keywords for this article
creatinine;
cystatin C;
glomerular filtration rate;
population-based study;
reference limits;
study of health in Pomerania
Articles in the same Issue
- Masthead
- Masthead
- Editorials
- Reference values and the journal: why the past is now present
- Other-than-annual variations in morning determinations of uric acid
- Reviews
- Blood biochemical markers of bone turnover: pre-analytical and technical aspects of sample collection and handling
- A comprehensive review of upper reference limits reported for (high-)sensitivity cardiac troponin assays: the challenges that lie ahead
- Mini Review
- Reference change values
- Opinion Papers
- Obtaining reference intervals traceable to reference measurement systems: is it possible, who is responsible, what is the strategy?
- Analytical performance, reference values and decision limits. A need to differentiate between reference intervals and decision limits and to define analytical quality specifications
- A pragmatic proposal for permissible limits in external quality assessment schemes with a compromise between biological variation and the state of the art
- Original Articles
- Age dependence of within-subject biological variation of nine common clinical chemistry analytes
- Population-based pediatric reference intervals for general clinical chemistry analytes on the Abbott Architect ci8200 instrument
- Uric acid biorhythm, a feature of long-term variation in a clinical laboratory database
- Age-related changes in serum amino acids concentrations in healthy individuals
- Characterisation of a highly sensitive troponin I assay and its application to a cardio-healthy population
- Are the currently used reference intervals for creatine kinase (CK) reflecting the general population? The Tromsø Study
- Age-specific thyroid hormone and thyrotropin reference intervals for a pediatric and adolescent population
- Serum thyroglobulin reference values according to NACB criteria in healthy subjects with normal thyroid ultrasound
- Thyroid volume influences serum calcitonin levels in a thyroid-healthy population: results of a 3-assay, 519 subjects study
- Impact of the reference values on the clinically-relevant cut-offs. The example of cortisol testing in children
- Trimester-specific reference intervals for haemoglobin A1c (HbA1c) in pregnancy
- The concentration of adiponectin in breast milk is related to maternal hormonal and inflammatory status during 6 months of lactation
- Age- and sex-specific reference limits for creatinine, cystatin C and the estimated glomerular filtration rate
- Determination of the biological variation of S100β and lactate dehydrogenase in disease-free patients with malignant melanoma
- Reference intervals and biological variation for kallikrein 6: influence of age and renal failure
- Faecal haemoglobin concentrations by gender and age: implications for population-based screening for colorectal cancer
- Reference intervals of extended erythrocyte and reticulocyte parameters
- Haematological and iron metabolism parameters in professional cyclists during the Giro d’Italia 3-weeks stage race
- Reference change values for lens culinaris agglutinin-reactive α-fetoprotein and des-γ-carboxy prothrombin in patients with chronic hepatitis C
- Letters to the Editor
- Disadvantages of using biological variation data for reference change values
- Reference change values may need some improvement but are invaluable tools in laboratory medicine
- Insulin-like growth factor 1 reference intervals for a chemiluminescent enzyme immunometric assay (Immulite 2000®) in an adult Mediterranean population
- Reference values for new red blood cell and platelet parameters on the Abbott Diagnostics Cell-Dyn Sapphire
- Congress Abstracts
- Swiss MedLab 2012 Congress of the Swiss Union of Laboratory Medicine (SULM)
