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Faecal haemoglobin concentrations by gender and age: implications for population-based screening for colorectal cancer
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Paula J. McDonald
Veröffentlicht/Copyright:
7. Dezember 2011
Abstract
Background: Faecal immunochemical tests (FIT) are becoming widely used in colorectal cancer screening. Estimation of faecal haemoglobin concentration in a large group prompted an observational study on gender and age.
Methods: A single estimate of faecal haemoglobin concentration was made using quantitative automated immunoturbidimetry. Potential reference intervals were calculated for men and women and for age quintiles according to the Clinical and Laboratory Standards Institute Approved Guideline. The percentages of positive results were calculated at a number of concentrations. The percentages of individuals who fell into different risk groups were assessed.
Results: The 97.5 percentiles, potential upper reference limits, were 519 ng haemoglobin/mL (90% CI: 468–575) for men and 283 ng haemoglobin/mL (90% CI: 257–316) for women. Concentrations increased with age in both genders. Decision limits have advantages over reference intervals. At any cut-off concentration, more men are declared positive than women and more older people are declared positive than younger people. Future risk of neoplasia is higher in men than in women and in older people.
Conclusions: Faecal haemoglobin concentrations vary with gender and age. More tailored strategies are needed in screening programmes. Faecal haemoglobin concentration could be included in individual risk assessment scores. These data should assist in screening programme design.
Keywords: colorectal cancer; decision limits; faecal immunochemical test; reference values; screening
Received: 2011-10-3
Accepted: 2011-11-11
Published Online: 2011-12-07
Published in Print: 2012-05-01
©2012 by Walter de Gruyter Berlin Boston
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Schlagwörter für diesen Artikel
colorectal cancer;
decision limits;
faecal immunochemical test;
reference values;
screening
Artikel in diesem Heft
- Masthead
- Masthead
- Editorials
- Reference values and the journal: why the past is now present
- Other-than-annual variations in morning determinations of uric acid
- Reviews
- Blood biochemical markers of bone turnover: pre-analytical and technical aspects of sample collection and handling
- A comprehensive review of upper reference limits reported for (high-)sensitivity cardiac troponin assays: the challenges that lie ahead
- Mini Review
- Reference change values
- Opinion Papers
- Obtaining reference intervals traceable to reference measurement systems: is it possible, who is responsible, what is the strategy?
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- A pragmatic proposal for permissible limits in external quality assessment schemes with a compromise between biological variation and the state of the art
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- Age dependence of within-subject biological variation of nine common clinical chemistry analytes
- Population-based pediatric reference intervals for general clinical chemistry analytes on the Abbott Architect ci8200 instrument
- Uric acid biorhythm, a feature of long-term variation in a clinical laboratory database
- Age-related changes in serum amino acids concentrations in healthy individuals
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- Are the currently used reference intervals for creatine kinase (CK) reflecting the general population? The Tromsø Study
- Age-specific thyroid hormone and thyrotropin reference intervals for a pediatric and adolescent population
- Serum thyroglobulin reference values according to NACB criteria in healthy subjects with normal thyroid ultrasound
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- Letters to the Editor
- Disadvantages of using biological variation data for reference change values
- Reference change values may need some improvement but are invaluable tools in laboratory medicine
- Insulin-like growth factor 1 reference intervals for a chemiluminescent enzyme immunometric assay (Immulite 2000®) in an adult Mediterranean population
- Reference values for new red blood cell and platelet parameters on the Abbott Diagnostics Cell-Dyn Sapphire
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