On the creation of wall shear stress by helical flow structures in stented coronary vessels
-
Michael Stiehm
,
Martin Brede
Abstract
The post-operative situation in a stented vessel is characterised by struts which extend into the vessel lumen. These barriers on the surface provoke a topological change of the blood flow inducing flow deceleration and stagnation zones. Low values of wall shear stress (WSS) especially up- and downstream of the struts are found accordingly. Clinical studies correlate the occurrence of complications like restenosis and thrombosis with the alteration of the spatial WSS distribution. In this study 3D computational models were used to characterise the flow topology of three different stent types. For this purpose steady state simulations of the flow field within a simplified stented coronary artery were performed. The stent types differ in their strut patterns so that the variation of the induced flow structures can be observed. The aim of these investigations is to evaluate the effect of a purposeful flow control by altering the design of the struts. An improved alignment of the struts will be able to guide the flow to benefit the spatial WSS distribution. To compare the performance of the different stent types the size of the area charged with a WSS value below 0.5 Pa is used as a criterion. We will demonstrate that those strut pattern which generate helical flow structures significantly reduce the critical region of low WSS values.
The investigations were performed within the REMEDIS project “Higher quality of life by novel micro-implants” (Project part B5), which is supported by the Federal Ministry for Education and Research within the initiative “Leading-Edge Research and Innovation in the New German States”.
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©2013 by Walter de Gruyter Berlin Boston
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Artikel in diesem Heft
- Masthead
- Masthead
- Editorial
- Editorial – BioNanomaterials Drive Innovation in Clinical Research
- Special issue on Nanosafety Part 1
- Editorial
- Editorial by the guest editors
- Reviews
- Human inhalation exposure to iron oxide particles
- Titanium dioxide nanoparticles and the oral uptake-route
- Highlights
- From nanoobject release of (Bio)nanomaterials to exposure
- Silver nanoparticles induce cytotoxicity, but not cell transformation or genotoxicity on Balb3T3 mouse fibroblasts
- Letter
- A comparative study of metal oxide nanoparticles embryotoxicity using the embryonic stem cell test
- Regular Research
- Review
- Blood protein and blood cell interactions with gold nanoparticles: the need for in vivo studies
- Highlight
- Emulsion synthesis of dicalcium phosphate particles for the preparation of calcium phosphate cements with improved compressive strengths and reduced setting times
- Letters
- Nanoporous silica coatings on implant surfaces: characterization, stability, biocompatibility and drug release properties
- Ensuring defined porosity and pore size using ammonium hydrogen carbonate as porosification agent for calcium phosphate scaffolds
- On the creation of wall shear stress by helical flow structures in stented coronary vessels
