Abstract
Up to now, it has been very challenging to manufacture a degradable bone replacement material having a specific pore size as well as a specific percentage of porosity which can be set independently of one another. We hypothesize that this is possible by using ammonium hydrogen carbonate (NH4HCO3) as porosification agent in varying particle size fractions and varying percentages in combination with β-tricalcium phosphate (β-TCP) material to manufacture tailored porous β-TCP scaffolds. In our study the pore sizes of the sintered material were comparable to the selected particle size fraction of the porosification agent. Porosities ranging between 71 and 78 vol.% were achieved. It was possible to control the volume percentage of porosity by using different weight ratios of NH4HCO3 and β-TCP. It can be concluded that ammonium hydrogen carbonate is an excellent porosification agent to design β-tricalcium phosphate scaffolds. This agent allows the independent setting of a specific pore size range as well as a specific volume percentage of porosity.
The authors appreciate the funding by the BMBF (German Federal Ministry of Education and Research) (03G0820A) for this study.
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©2013 by Walter de Gruyter Berlin Boston
Articles in the same Issue
- Masthead
- Masthead
- Editorial
- Editorial – BioNanomaterials Drive Innovation in Clinical Research
- Special issue on Nanosafety Part 1
- Editorial
- Editorial by the guest editors
- Reviews
- Human inhalation exposure to iron oxide particles
- Titanium dioxide nanoparticles and the oral uptake-route
- Highlights
- From nanoobject release of (Bio)nanomaterials to exposure
- Silver nanoparticles induce cytotoxicity, but not cell transformation or genotoxicity on Balb3T3 mouse fibroblasts
- Letter
- A comparative study of metal oxide nanoparticles embryotoxicity using the embryonic stem cell test
- Regular Research
- Review
- Blood protein and blood cell interactions with gold nanoparticles: the need for in vivo studies
- Highlight
- Emulsion synthesis of dicalcium phosphate particles for the preparation of calcium phosphate cements with improved compressive strengths and reduced setting times
- Letters
- Nanoporous silica coatings on implant surfaces: characterization, stability, biocompatibility and drug release properties
- Ensuring defined porosity and pore size using ammonium hydrogen carbonate as porosification agent for calcium phosphate scaffolds
- On the creation of wall shear stress by helical flow structures in stented coronary vessels
Articles in the same Issue
- Masthead
- Masthead
- Editorial
- Editorial – BioNanomaterials Drive Innovation in Clinical Research
- Special issue on Nanosafety Part 1
- Editorial
- Editorial by the guest editors
- Reviews
- Human inhalation exposure to iron oxide particles
- Titanium dioxide nanoparticles and the oral uptake-route
- Highlights
- From nanoobject release of (Bio)nanomaterials to exposure
- Silver nanoparticles induce cytotoxicity, but not cell transformation or genotoxicity on Balb3T3 mouse fibroblasts
- Letter
- A comparative study of metal oxide nanoparticles embryotoxicity using the embryonic stem cell test
- Regular Research
- Review
- Blood protein and blood cell interactions with gold nanoparticles: the need for in vivo studies
- Highlight
- Emulsion synthesis of dicalcium phosphate particles for the preparation of calcium phosphate cements with improved compressive strengths and reduced setting times
- Letters
- Nanoporous silica coatings on implant surfaces: characterization, stability, biocompatibility and drug release properties
- Ensuring defined porosity and pore size using ammonium hydrogen carbonate as porosification agent for calcium phosphate scaffolds
- On the creation of wall shear stress by helical flow structures in stented coronary vessels