Hyperspectral imaging as a possible tool for visualization of changes in hemoglobin oxygenation in patients with deficient hemodynamics – proof of concept
-
Claudia Sicher
, Rico Rutkowski
Abstract
There is a lack of imaging tools for the evaluation of spatial alterations in microcirculation including blood oxygen saturation and hemoglobin distribution but recent innovative developments in hyperspectral technology may offer a solution. We examined different hemodynamic disorders in patients suffering from scleroderma, Dupuytren surgery, chronic foot ulcera and skin infections. Superficial and deeper blood oxygen saturation, hemoglobin distribution and water content were determined using hyperspectral imaging (HSI). In the patient with scleroderma, distinct cutaneous low perfused regions correlated with macroscopic skin aspects and seem to be potential therapy control marker. With HSI accurate clinical evaluation of a macroscopic conspicuous wound after Dupuytren surgery was possible and influenced further surveillance decisions. HSI clearly revealed the spatial geometry and also the clinically related perfusion parameters of abscess formation and chronic ulcer wounds. The hemodynamically relevant parameters like blood oxygen saturation (1 mm to approx. 6 mm subcutaneous), total hemoglobin distribution and tissue water content can be easily determined and visualized with HSI in near real time. Hence, this technique seems to be suitable for routine diagnostics of acute and chronic wounds as well as for the examination of systemic hemodynamic disturbances. Special indications may be transplant surveillance and monitoring of therapeutical interventions.
Author Statement
Research funding: Authors state no funding involved.
Conflict of interest: Authors state no conflict of interest.
Informed consent: Informed consent has been obtained from all individuals.
Ethical approval: The research related to human use complied with all the relevant national regulations and institutional policies and was performed in accordance to the tenets of the Declaration of Helsinki and has been approved by the author’s institutional review board or equivalent committee.
References
[1] Goldman RJ, Salcido R. More than one way to measure a wound: an overview of tools and techniques. Adv Skin Wound Care 2002;15:236–43.10.1097/00129334-200209000-00011Suche in Google Scholar PubMed
[2] Lal C, Banerjee A, Sujatha NU. Role of contrast and fractality of laser speckle image in assessing flow velocity and scatterer concentration in phantom body fluids. J Biomed Opt 2013;18:111419.10.1117/1.JBO.18.11.111419Suche in Google Scholar PubMed
[3] Creutzig A, Dau D, Caspary L, Alexander K. Transcutaneous oxygen pressure measured at two different electrode temperatures in healthy volunteers and patients with arterial occlusive disease. Int J Microcirc Clin Exp 1987;5:373–80.Suche in Google Scholar
[4] Duann JR, Jan CI, Ou-Yang M. Separating spectral mixtures in hyperspectral image data using independent component analysis: validation with oral cancer tissue sections. J Biomed Opt 2013;18:126005.10.1117/1.JBO.18.12.126005Suche in Google Scholar PubMed
[5] Goetz AFH. Three decades of hyperspectral remote sensing of the Earth: a personal view. Remote Sens Environ 2009;113:5–16.10.1016/j.rse.2007.12.014Suche in Google Scholar
[6] Yudovsky D, Nouvong A, Pilon L. Hyperspectral imaging in diabetic foot wound care. J Diabetes Sci Technol 2010;4: 1099–113.10.1177/193229681000400508Suche in Google Scholar PubMed PubMed Central
[7] Holmer A, Tetschke F, Marotz J, Malberg H, Markgraf W, Thiele C, et al. Oxygenation and perfusion monitoring with a hyperspectral camera system for chemical based tissue analysis of skin and organs. Physiol Meas 2016;37:2064–78.10.1088/0967-3334/37/11/2064Suche in Google Scholar PubMed
[8] Holmer A, Wahl P, Marotz J, Dau M, Kaemmerer P. Hyperspectral imaging in perfusion and wound diagnostics – methods and algorithms for the determination of tissue parameters. Biomed Eng Biomed Tech 2017 [Epub ahead of print].10.1515/bmt-2017-0155Suche in Google Scholar PubMed
[9] Azizi B, Wong T, Wan J, Singer S, Hudson C. The impact of cataract on the quantitative, non-invasive assessment of retinal blood flow. Acta Ophthalmol 2012;90:e9–12.10.1111/j.1755-3768.2011.02223.xSuche in Google Scholar PubMed
[10] Wild T, Becker M, Winter J, Schuhschenk N, Daeschlein G, Siemers F. Hyperspectral imaging of tissue perfusion and oxygenation in wounds: assessing the impact of a micro capillary dressing. J Wound Care 2018;27:38–51.10.12968/jowc.2018.27.1.38Suche in Google Scholar PubMed
[11] Denstedt M, Pukstad BS, Paluchowski LA, Hernandez-Palacios JE, Randeberg LL. Hyperspectral imaging as a diagnostic tool for chronic skin ulcers. Proc SPIE 2013;8565.10.1117/12.2001087Suche in Google Scholar
[12] Nouri D, Lucas Y, Treuillet S, Jolivot R, Marzani F. Colour and multispectral imaging for wound healing evaluation in the context of a comparative preclinical study. Proc SPIE 2013;8669.10.1117/12.2003943Suche in Google Scholar
[13] Calin MA, Parasca SV, Savastru R, Manea D. Characterization of burns using hyperspectral imaging technique: a preliminary study. Burns 2015;41:118–24.10.1016/j.burns.2014.05.002Suche in Google Scholar PubMed
[14] Khaodhiar L, Dinh T, Schomacker KT, Panasyuk SV, Freeman JE, Lew R, et al. The use of medical hyperspectral technology to evaluate microcirculatory changes in diabetic foot ulcers and to predict clinical outcomes. Diabetes Care 2007;30:903–10.10.2337/dc06-2209Suche in Google Scholar PubMed
[15] Chin JA, Wang EC, Kibbe MR. Evaluation of hyperspectral technology for assessing the presence and severity of peripheral artery disease. J Vasc Surg 2011;54:1679–88.10.1016/j.jvs.2011.06.022Suche in Google Scholar PubMed
[16] Chin MS, Oqawa R, Lancerotto L, Pietramaggiori G, Schomacker KT, Mathews JC, et al. In vivo acceleration of skin growth using a servocontrolled stretching device. Tissue Eng Part C Methods 2010;16:397–405.10.1089/ten.tec.2009.0185Suche in Google Scholar PubMed
[17] Cancio LC, Batchinsky AI, Mansfield JR, Panasyuk S, Hetz K, Martini D, et al. Hyperspectral imaging: a new approach to the diagnosis of hemorrhagic shock. J Trauma 2006;60:1087–95.10.1097/01.ta.0000217357.10617.3dSuche in Google Scholar PubMed
[18] Panasyuk SV, Yang S, Faller DV, Ngo D, Lew RA, Freeman JE, et al. Medical hyperspectral imaging to facilitate residual tumor identification during surgery. Cancer Biol Ther 2007;6:439–46.10.4161/cbt.6.3.4018Suche in Google Scholar PubMed
[19] Gerstner AO, Laffers W, Bootz F, Farkas DL, Martin R, Bendix J, et al. Hyperspectral imaging of mucosal surfaces in patients. J Biophotonics 2012;5:255–62.10.1002/jbio.201100081Suche in Google Scholar PubMed
[20] Holzer MS, Best SL, Jackson N, Thapa A, Raj GV, Cadeddu JA, et al. Assessment of renal oxygenation during partial nephrectomy using hyperspectral imaging. J Urol 2011;186:400–4.10.1016/j.juro.2011.03.162Suche in Google Scholar PubMed
[21] Zuzak KJ, Francis RP, Wehner EF, Smith J, Litorja M, Allen DW, et al. DLP hyperspectral imaging for surgical and clinical utility. Proc SPIE 2009;7210:721006.10.1117/12.810068Suche in Google Scholar
[22] Akbari H, Kosugi Y, Kojima K, Tanaka N. Blood vessel detection and artery-vein differentiation using hyperspectral imaging. Annual International Conference IEEE Engineering in Medicine and Biology Society 2009;1461–4.10.1109/IEMBS.2009.5332920Suche in Google Scholar PubMed
©2018 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Guest Editorial
- Optical imaging methods in medicine: how can we escape the plausibility trap?
- Special Issue Articles
- Diffuse near-infrared imaging of tissue with picosecond time resolution
- A compact hyperspectral camera for measurement of perfusion parameters in medicine
- LED for hyperspectral imaging – a new selection method
- Approaches for calibration and validation of near-infrared optical methods for oxygenation monitoring
- Hyperspectral imaging in perfusion and wound diagnostics – methods and algorithms for the determination of tissue parameters
- Algorithms for mapping kidney tissue oxygenation during normothermic machine perfusion using hyperspectral imaging
- Intraoperative mapping of the sensory cortex by time-resolved thermal imaging
- Intraoperative motion correction in neurosurgery: a comparison of intensity- and feature-based methods
- Optical molecular imaging of corpora amylacea in human brain tissue
- Intraoperative optical imaging of metabolic changes after direct cortical stimulation – a clinical tool for guidance during tumor resection?
- Application of optical and spectroscopic technologies for the characterization of carious lesions in vitro
- Hyperspectral imaging: innovative diagnostics to visualize hemodynamic effects of cold plasma in wound therapy
- Hyperspectral imaging as a possible tool for visualization of changes in hemoglobin oxygenation in patients with deficient hemodynamics – proof of concept
- Cardiovascular assessment by imaging photoplethysmography – a review
Artikel in diesem Heft
- Frontmatter
- Guest Editorial
- Optical imaging methods in medicine: how can we escape the plausibility trap?
- Special Issue Articles
- Diffuse near-infrared imaging of tissue with picosecond time resolution
- A compact hyperspectral camera for measurement of perfusion parameters in medicine
- LED for hyperspectral imaging – a new selection method
- Approaches for calibration and validation of near-infrared optical methods for oxygenation monitoring
- Hyperspectral imaging in perfusion and wound diagnostics – methods and algorithms for the determination of tissue parameters
- Algorithms for mapping kidney tissue oxygenation during normothermic machine perfusion using hyperspectral imaging
- Intraoperative mapping of the sensory cortex by time-resolved thermal imaging
- Intraoperative motion correction in neurosurgery: a comparison of intensity- and feature-based methods
- Optical molecular imaging of corpora amylacea in human brain tissue
- Intraoperative optical imaging of metabolic changes after direct cortical stimulation – a clinical tool for guidance during tumor resection?
- Application of optical and spectroscopic technologies for the characterization of carious lesions in vitro
- Hyperspectral imaging: innovative diagnostics to visualize hemodynamic effects of cold plasma in wound therapy
- Hyperspectral imaging as a possible tool for visualization of changes in hemoglobin oxygenation in patients with deficient hemodynamics – proof of concept
- Cardiovascular assessment by imaging photoplethysmography – a review