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A compact hyperspectral camera for measurement of perfusion parameters in medicine

  • Axel Kulcke EMAIL logo , Amadeus Holmer , Philip Wahl , Frank Siemers , Thomas Wild and Georg Daeschlein
Published/Copyright: March 9, 2018
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Biomedical Engineering / Biomedizinische Technik
From the journal Biomedical Engineering / Biomedizinische Technik Volume 63 Issue 5

Abstract

Worldwide, chronic wounds are still a major and increasing problem area in medicine with protracted suffering of patients and enormous costs. Beside conventional wound treatment, for instance kinds of oxygen therapy and cold plasma technology have been tested, providing an improvement in the perfusion of wounds and their healing potential, but these methods are unfortunately not sufficiently validated and accepted for clinical practice to date. Using hyperspectral imaging technology in the visible (VIS) and near infrared (NIR) region with high spectral and spatial resolution, perfusion parameters of tissue and wounds can be determined. We present a new compact hyperspectral camera which can be used in clinical practice. From hyperspectral data the hemoglobin oxygenation (StO2), the relative concentration of hemoglobin [tissue hemoglobin index (THI)] and the so-called NIR-perfusion index can be determined. The first two parameters are calculated from the VIS-part of the spectrum and represent the perfusion of superficial tissue layers, whereas the NIR-perfusion index is calculated from the NIR-part representing the perfusion in deeper layers. First clinical measurements of transplanted flaps and chronic ulcer wounds show, that the perfusion level can be determined quantitatively allowing sensitive evaluation and monitoring for an optimization of the wound treatment planning and for validation of new treatment methods.

Keywords: free flap monitoring; hyperspectral imaging; perfusion imaging; tissue oxygenation; wound diagnostics

  1. Author Statement

  2. Research funding: Authors state no funding involved.

  3. Conflict of interest: The hyperspectral camera prototype described in this publication was developed by Diaspective Vision GmbH. The first, second and third author are employees of this company. In the long term, Diaspective Vision has proprietary interest in the development of the camera system resulting in a product for routine clinical use. The clinical tests of the camera have been performed by clinicians (authors 4, 5 and 6). We certify that the clinical investigators and co-authors have no financial interests and financial arrangements with Diaspective Vision and have received no funding for the measurements and/or preparation of this manuscript. The cameras used during the measurements have been provided by Diaspective Vision.

  4. Informed consent: All patients have signed an informed consent.

  5. Ethical approval: Experimental hyperspectral measurements from patients for the evaluation of the new technology for perfusion measurements and wound description have obtained the ethics approval by the Ethics committee of the Ärztekammer Sachsen-Anhalt, Germany (35/17) and the Ethics Committee of the University of Greifswald (EUDAMED-No. CIV-17-02-018504). The study was conducted according to the Declaration of Helsinki.

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Received: 2017-08-18
Accepted: 2017-12-04
Published Online: 2018-03-09
Published in Print: 2018-10-25

©2018 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Guest Editorial
  3. Optical imaging methods in medicine: how can we escape the plausibility trap?
  4. Special Issue Articles
  5. Diffuse near-infrared imaging of tissue with picosecond time resolution
  6. A compact hyperspectral camera for measurement of perfusion parameters in medicine
  7. LED for hyperspectral imaging – a new selection method
  8. Approaches for calibration and validation of near-infrared optical methods for oxygenation monitoring
  9. Hyperspectral imaging in perfusion and wound diagnostics – methods and algorithms for the determination of tissue parameters
  10. Algorithms for mapping kidney tissue oxygenation during normothermic machine perfusion using hyperspectral imaging
  11. Intraoperative mapping of the sensory cortex by time-resolved thermal imaging
  12. Intraoperative motion correction in neurosurgery: a comparison of intensity- and feature-based methods
  13. Optical molecular imaging of corpora amylacea in human brain tissue
  14. Intraoperative optical imaging of metabolic changes after direct cortical stimulation – a clinical tool for guidance during tumor resection?
  15. Application of optical and spectroscopic technologies for the characterization of carious lesions in vitro
  16. Hyperspectral imaging: innovative diagnostics to visualize hemodynamic effects of cold plasma in wound therapy
  17. Hyperspectral imaging as a possible tool for visualization of changes in hemoglobin oxygenation in patients with deficient hemodynamics – proof of concept
  18. Cardiovascular assessment by imaging photoplethysmography – a review
https://doi.org/10.1515/bmt-2017-0145
Keywords for this article
free flap monitoring; hyperspectral imaging; perfusion imaging; tissue oxygenation; wound diagnostics

Articles in the same Issue

  1. Frontmatter
  2. Guest Editorial
  3. Optical imaging methods in medicine: how can we escape the plausibility trap?
  4. Special Issue Articles
  5. Diffuse near-infrared imaging of tissue with picosecond time resolution
  6. A compact hyperspectral camera for measurement of perfusion parameters in medicine
  7. LED for hyperspectral imaging – a new selection method
  8. Approaches for calibration and validation of near-infrared optical methods for oxygenation monitoring
  9. Hyperspectral imaging in perfusion and wound diagnostics – methods and algorithms for the determination of tissue parameters
  10. Algorithms for mapping kidney tissue oxygenation during normothermic machine perfusion using hyperspectral imaging
  11. Intraoperative mapping of the sensory cortex by time-resolved thermal imaging
  12. Intraoperative motion correction in neurosurgery: a comparison of intensity- and feature-based methods
  13. Optical molecular imaging of corpora amylacea in human brain tissue
  14. Intraoperative optical imaging of metabolic changes after direct cortical stimulation – a clinical tool for guidance during tumor resection?
  15. Application of optical and spectroscopic technologies for the characterization of carious lesions in vitro
  16. Hyperspectral imaging: innovative diagnostics to visualize hemodynamic effects of cold plasma in wound therapy
  17. Hyperspectral imaging as a possible tool for visualization of changes in hemoglobin oxygenation in patients with deficient hemodynamics – proof of concept
  18. Cardiovascular assessment by imaging photoplethysmography – a review
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