Synthesis of multifunctional γ-PGA-based superparamagnetic iron oxide nanoparticles for magnetic resonance imaging and controlled drug release
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Alphonsa Jose Anju
und
Parameswaran Binod
Abstract
The anionic, water soluble, biodegradable and biocompatible polymer, poly-γ-glutamic acid (γ-PGA) was produced by a Bacillus amyloliquefaciens strain and converted into its nanomeric form for theranostic purpose. In this study, superparamagnetic iron oxide nanoparticles (SPIONs) modified with γ-PGA was prepared by co-precipitation method, and the anticancer drug doxorubicin (DOX) was loaded onto the polymer matrix. This complex assembles as spherical in shape with 82 nm particle size. We hypothesize that SPIONs could deliver the nanoparticle to the target site. The cationic DOX was loaded into the polymer matrix by electrostatic interactions with high loading efficiency and it was confirmed by fluorescence spectroscopy. This multifunctional nanomaterial could be used as the nanomedicine for drug delivery and also for the real time monitoring of the disease progress.
Acknowledgements
Author AAJ acknowledges University Grants Commission, New Delhi, for financial support for doctoral studies.
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- Abbreviations
- DLS
dynamic light scattering
- DOX
doxorubicin
- FT-IR
Fourier transform infrared spectroscopy
- γ- PGA
poly-γ-glutamic acid
- MRI
magnetic resonance imaging
- SPIONs
superparamagnetic iron oxide nanoparticles
- TEM
transmission electron microscopy
- VSM
vibrating sample magnetometer
©2016 Institute of Molecular Biology, Slovak Academy of Sciences
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Artikel in diesem Heft
- Synthesis of multifunctional γ-PGA-based superparamagnetic iron oxide nanoparticles for magnetic resonance imaging and controlled drug release
- Organic solvent stable protease isolation and characterization from organic solvent tolerant strain of Lysinibacillus sphaericus PAP02
- The impact of grazing absence in inland saline vegetation – a case study from Slovakia
- How dose of biochar and biochar with nitrogen can improve the parameters of soil organic matter and soil structure?
- Water repellent effects of manure amended soils on organic matter decomposition, C retention, and respired CO2-C
- Rainfall interception in a disturbed montane spruce (Picea abies) stand in the West Tatra Mountains
- ASL16 gene, a member of AS2/LOB family, is essential for lateral root formation in Arabidopsis
- Meiobenthic Assemblages from the Southwestern Coast of the Black Sea, İğneada (Turkey)
- Oviposition by selected water mite (Hydrachnidia) species from Lake Skadar and its catchment
- Parasitic mesostigmatid mites (Acari) – common inhabitants of the nest boxes of starlings (Sturnus vulgaris) in a Polish urban habitat
- Mayfly (Insecta: Ephemeroptera) assemblages of a regulated perennial Mediterranean river system in the Western Balkans
- Distribution and ecology of the flightless bush-cricket Poecilimon schmidtii at its northern range margin
- Sexual size monomorphism and body variation in the fat dormouse Glis glis in Slovakia
