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Towards molecular systems biology of gene transcription and regulation
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Patrick Cramer
Published/Copyright:
May 19, 2010
Abstract
Ten years after the determination of the RNA polymerase II structure, the basic mechanism of mRNA synthesis during gene transcription is known. In the future, the initiation and regulation of transcription must be studied with a combination of structural biology, biochemistry, functional genomics, and computational methods. In this article, the efforts of our laboratory to move from an integrated structural biology of gene transcription towards molecular systems biology of gene regulation are reviewed.
Keywords: gene transcription and regulation; integrated structural biology; molecular systems biology; RNA polymerase; yeast
Received: 2010-1-26
Accepted: 2010-3-31
Published Online: 2010-05-19
Published in Print: 2010-07-01
©2010 by Walter de Gruyter Berlin New York
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Keywords for this article
gene transcription and regulation;
integrated structural biology;
molecular systems biology;
RNA polymerase;
yeast
Articles in the same Issue
- Guest Editorial
- Highlight: Of Systems and Structures
- HIGHLIGHT: STRUCTURAL SYSTEMS BIOLOGY
- Converging on the function of intrinsically disordered nucleoporins in the nuclear pore complex
- Towards molecular systems biology of gene transcription and regulation
- Small-angle X-ray and neutron scattering as a tool for structural systems biology
- The type III secretion injectisome, a complex nanomachine for intracellular ‘toxin’ delivery
- Structural insights into the evolution of the adaptive immune system: the variable lymphocyte receptors of jawless vertebrates
- The XPD helicase: XPanDing archaeal XPD structures to get a grip on human DNA repair
- Decoding transcription and microRNA-mediated translation control in Drosophila development
- Human SepSecS or SLA/LP: selenocysteine formation and autoimmune hepatitis
- PROTEIN STRUCTURE AND FUNCTION
- The rhodanese RhdA helps Azotobacter vinelandii in maintaining cellular redox balance
- MEMBRANES, LIPIDS, GLYCOBIOLOGY
- The membrane-bound bile acid receptor TGR5 (Gpbar-1) is localized in the primary cilium of cholangiocytes
- CELL BIOLOGY AND SIGNALING
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