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Decoding transcription and microRNA-mediated translation control in Drosophila development
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Ulrike Gaul
Published/Copyright:
May 19, 2010
Abstract
The spatio-temporal regulation of gene expression lies at the heart of animal development. In this article we present an overview of our recent work to apply systems biological approaches to the study of transcription and microRNA-mediated translation control in Drosophila development. We have identified many new cis-regulatory elements within the segmentation gene network, a transcriptional hierarchy governing pattern formation along the antero-posterior axis of the embryo, and developed a novel thermodynamic model to predict their expression. A similar thermodynamic approach that takes into account the secondary structure of the target mRNA significantly improves the prediction of microRNA binding sites.
Keywords: cis-regulatory element; Drosophila; gene regulation; microRNA; segmentation; systems biology; thermodynamic modeling
Received: 2010-1-26
Accepted: 2010-4-20
Published Online: 2010-05-19
Published in Print: 2010-07-01
©2010 by Walter de Gruyter Berlin New York
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Keywords for this article
cis-regulatory element;
Drosophila;
gene regulation;
microRNA;
segmentation;
systems biology;
thermodynamic modeling
Articles in the same Issue
- Guest Editorial
- Highlight: Of Systems and Structures
- HIGHLIGHT: STRUCTURAL SYSTEMS BIOLOGY
- Converging on the function of intrinsically disordered nucleoporins in the nuclear pore complex
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- Structural insights into the evolution of the adaptive immune system: the variable lymphocyte receptors of jawless vertebrates
- The XPD helicase: XPanDing archaeal XPD structures to get a grip on human DNA repair
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