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Perinatal outcomes after second trimester detection of amniotic fluid viral genome in asymptomatic patients
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Jena L. Miller
Published/Copyright:
October 28, 2008
Abstract
Objective: Symptomatic fetal viral infection can affect placental and fetal development and may lead to non-immune hydrops or fetal death. All infections are not detectable by clinical history or ultrasound and a background positivity rate exists in asymptomatic patients. We investigated if intraamniotic presence of viral genome at the time of genetic amniocentesis in asypmtomatic patients affects perinatal outcome.
Study design: Six-hundred and eighty-six pregnancies referred for second trimester genetic amniocentesis with a normal ultrasound and fetal karyotype had amniotic fluid multiplex polymerase chain reaction for adeno-, cytomegalo-, Ebstein-Barr-, entero- and parvovirus. Forty asymptomatic patients that were positive for viral genome were matched 2:1 with negative controls. Perinatal outcomes were compared between these groups.
Results: Pregnancy complications and perinatal outcomes were similar in the two groups.
Conclusion: Asymptomatic fetal viral infection at the time of second trimester amniocentesis does not increase the risk for adverse perinatal outcome.
Keywords: Amniocentesis; polymerase chain reaction; pregnancy outcome; second trimester; viral infection
Received: 2008-6-10
Accepted: 2008-10-7
Published Online: 2008-10-28
Published Online: 2008-10-28
Published in Print: 2009-03-01
©2009 by Walter de Gruyter Berlin New York
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Keywords for this article
Amniocentesis;
polymerase chain reaction;
pregnancy outcome;
second trimester;
viral infection
Articles in the same Issue
- Selected articles from the 31st scientific meeting of the New York Perinatal Society on May 19, 2008
- Advanced maternal age as a sole indication for genetic amniocentesis; risk-benefit analysis based on a large database reflecting the current common practice
- Risks for common medical conditions experienced by former preterm infants during toddler years
- Predictors of severe perineal lacerations in Chinese women
- Maternal and neonatal outcomes in early glucose tolerance testing in an obstetric population in New York city
- Original articles – Obstetrics
- Prelabor rupture of membranes at term requiring labor induction – a feature of occult fetal cephalopelvic disproportion?
- Group B Streptococcus colonization in pregnancy: prevalence and prevention strategies of neonatal sepsis
- Preterm labor and bacterial vaginosis-associated bacteria among urban women
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