Lipopolysaccharide binding protein in the early diagnosis of intraamniotic infection of pregnant women with premature rupture of the membranes
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Frank C.-K. Chen
Abstract
Aims: To investigate whether lipopolysaccharide binding protein (LBP) level is an early marker of intraamniotic infection in pregnant women with premature rupture of the membranes (PROM) and compare it to C-reactive protein (CRP).
Methods: Seventy-two pregnant women with PROM were included in the study if remained undelivered for more than 24 h. CRP and LBP concentrations were determined in 12-h-intervals and the last value before delivery was correlated with obstetrical data and placenta histology.
Results: LBP concentrations ranged from 1.6 to 48.7 μg/mL (median of 16 μg/mL) and CRP concentrations from 0.02 to 6.8 mg/dL (0.64 mg/dL). CRP was significantly elevated when full blown chorioamnionitis was proven by histology (P<0.01) and when the neonates had to be admitted to the intensive care unit because of suspected infection (P<0.05 mg/dL). There were significantly higher LBP levels when fetal tachycardia occurred (20.3 vs. 14.5 μg/mL, P<0.05) and when intraamniotic infection was diagnosed by histology (22.8 vs. 14.1 μg/mL, P<0.005), but the differences were too little to provide prognostic cut-off values.
Conclusion: Increase of LBP and CRP levels after PROM seem to reflect intramniotic infection, but no cut-off values could be defined for the prediction of intraamniotic infection.
©2009 by Walter de Gruyter Berlin New York
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- Congress Calender
- Congress Calendar
- WAPM-Newsletter 1/2009: Istanbul Declaration on following Ethics in Perinatal Medicine
- WAPM-Newsletter No 1/2009
Articles in the same Issue
- Selected articles from the 31st scientific meeting of the New York Perinatal Society on May 19, 2008
- Advanced maternal age as a sole indication for genetic amniocentesis; risk-benefit analysis based on a large database reflecting the current common practice
- Risks for common medical conditions experienced by former preterm infants during toddler years
- Predictors of severe perineal lacerations in Chinese women
- Maternal and neonatal outcomes in early glucose tolerance testing in an obstetric population in New York city
- Original articles – Obstetrics
- Prelabor rupture of membranes at term requiring labor induction – a feature of occult fetal cephalopelvic disproportion?
- Group B Streptococcus colonization in pregnancy: prevalence and prevention strategies of neonatal sepsis
- Preterm labor and bacterial vaginosis-associated bacteria among urban women
- Lipopolysaccharide binding protein in the early diagnosis of intraamniotic infection of pregnant women with premature rupture of the membranes
- Perinatal outcomes after second trimester detection of amniotic fluid viral genome in asymptomatic patients
- Is induced abortion a risk factor in subsequent pregnancy?
- An approach to the prediction of neonatal Erb palsy
- External cephalic version among women with a previous cesarean delivery: report on 36 cases and review of the literature
- Original articles – Fetus
- Reference range of fetal lung volume by 3D-ultrasonography using the rotational method (VOCAL)
- Sex differences in linear and complex fetal heart rate dynamics of normal and acidemic fetuses in the minutes preceding delivery
- Misidentification of maternal for fetal heart rate patterns after delivery of the first twin
- Original articles – Newborn
- Prevalence and risk factors for hypothermia on admission in Nigerian babies <72 h of age
- Influence of sociodemographic and psychosocial characteristics on breastfeeding duration of mothers attending breastfeeding support groups
- Congress Calender
- Congress Calendar
- WAPM-Newsletter 1/2009: Istanbul Declaration on following Ethics in Perinatal Medicine
- WAPM-Newsletter No 1/2009
