Group B Streptococcus colonization in pregnancy: prevalence and prevention strategies of neonatal sepsis
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Alma-Verena Rausch
Abstract
Early onset neonatal sepsis due to Group B streptococci (GBS) is responsible for severe morbidity and mortality of newborns. While different preventive strategies to identify women at risk are being recommended, the optimal strategy depends on the incidence of GBS-sepsis and on the prevalence of anogenital GBS colonization. We therefore aimed to assess the Group B streptococci prevalence and its consequences on different prevention strategies.
We analyzed 1316 pregnant women between March 2005 and September 2006 at our institution. The prevalence of GBS colonization was determined by selective cultures of anogenital smears. The presence of risk factors was analyzed. In addition, the direct costs of screening and intrapartum antibiotic prophylaxis were estimated for different preventive strategies.
The prevalence of GBS colonization was 21%. Any maternal intrapartum risk factor was present in 37%. The direct costs of different prevention strategies have been estimated as follows: risk-based: 18,500 CHF/1000 live births, screening-based: 50,110 CHF/1000 live births, combined screening- and risk-based: 43,495/1000 live births.
Strategies to prevent GBS-sepsis in newborn are necessary. With our colonization prevalence of 21%, and the intrapartum risk profile of women, the screening-based approach seems to be superior as compared to a risk-based approach.
©2009 by Walter de Gruyter Berlin New York
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- Congress Calender
- Congress Calendar
- WAPM-Newsletter 1/2009: Istanbul Declaration on following Ethics in Perinatal Medicine
- WAPM-Newsletter No 1/2009
Articles in the same Issue
- Selected articles from the 31st scientific meeting of the New York Perinatal Society on May 19, 2008
- Advanced maternal age as a sole indication for genetic amniocentesis; risk-benefit analysis based on a large database reflecting the current common practice
- Risks for common medical conditions experienced by former preterm infants during toddler years
- Predictors of severe perineal lacerations in Chinese women
- Maternal and neonatal outcomes in early glucose tolerance testing in an obstetric population in New York city
- Original articles – Obstetrics
- Prelabor rupture of membranes at term requiring labor induction – a feature of occult fetal cephalopelvic disproportion?
- Group B Streptococcus colonization in pregnancy: prevalence and prevention strategies of neonatal sepsis
- Preterm labor and bacterial vaginosis-associated bacteria among urban women
- Lipopolysaccharide binding protein in the early diagnosis of intraamniotic infection of pregnant women with premature rupture of the membranes
- Perinatal outcomes after second trimester detection of amniotic fluid viral genome in asymptomatic patients
- Is induced abortion a risk factor in subsequent pregnancy?
- An approach to the prediction of neonatal Erb palsy
- External cephalic version among women with a previous cesarean delivery: report on 36 cases and review of the literature
- Original articles – Fetus
- Reference range of fetal lung volume by 3D-ultrasonography using the rotational method (VOCAL)
- Sex differences in linear and complex fetal heart rate dynamics of normal and acidemic fetuses in the minutes preceding delivery
- Misidentification of maternal for fetal heart rate patterns after delivery of the first twin
- Original articles – Newborn
- Prevalence and risk factors for hypothermia on admission in Nigerian babies <72 h of age
- Influence of sociodemographic and psychosocial characteristics on breastfeeding duration of mothers attending breastfeeding support groups
- Congress Calender
- Congress Calendar
- WAPM-Newsletter 1/2009: Istanbul Declaration on following Ethics in Perinatal Medicine
- WAPM-Newsletter No 1/2009
