Does maternal docosahexaenoic acid supplementation during pregnancy and lactation lower BMI in late infancy?
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Renate Lucia Bergmann
Abstract
We compared growth of infants whose mothers either did or did not receive docosahexaenoic acid (DHA) supplements during pregnancy and lactation. At 21 weeks' gestation, 144 women were enrolled into a randomized, double-blind clinical trial receiving: (1) a basic supplement consisting of vitamins and minerals (BS), or (2) BS plus 4.5 g fructooligosaccharide (BSF), or (3) BSF plus fish oil DHA (200 mg) until the end of the third month of lactation. Infants' length, weight and head circumference were measured at birth and at 1, 3 and 21 months. A total of 51 mothers/infants were lost to follow-up by the third month and 24 at 21 months. The two groups not receiving DHA were combined into a control group. Analysis with mixed models adjusted for confounding factors showed a significant time dependent effect for the DHA group on the development of the body mass index (BMI) (P=0.037), and of weight (P=0.046), but no effect on the development of length (P=0.537), or of head circumference (P=0.267). At 21 months, weight of the DHA group was lower by −601 g (95% CI −171; −1030 g) and BMI was lower by −0.76 kg/m2 (95% CI −0.07; −1.46) compared to controls. The results indicate that DHA taken by pregnant and lactating mothers may reduce BMI in late infancy.
©2007 by Walter de Gruyter Berlin New York
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Articles in the same Issue
- WAPM-Newsletter No 1/2007 8th WORLD CONGRESS OF PERINATAL MEDICINE in Florence, Italy, September 9–13, 2007
- Poverty and perinatal health
- Maternal mortality in Africa
- Lessons learned from four advanced abdominal pregnancies at an East African Health Center
- Incidence and correlates of cesarean section in a capital city of a middle-income country
- Metabolic changes, hypothalamo-pituitary-adrenal axis and oxidative stress after short-term starvation in healthy pregnant women
- Does maternal docosahexaenoic acid supplementation during pregnancy and lactation lower BMI in late infancy?
- Feasibility of a randomized controlled trial testing nifedipine vs. placebo for the treatment of preterm labor
- Atosiban versus usual care for the management of preterm labor
- Umbilical cord blood collection: do patients really understand?
- Comparison between singleton- and triplet-specific “growth” curves to detect growth restricted triplet infants
- Role of visfatin, insulin-like growth factor-I and insulin in fetal growth
- Dynamic QT/RR relationship of cardiac conduction in premature infants treated with low-dose doxapram hydrochloride
- Risk factors and outcomes for ventilator-associated pneumonia in neonatal intensive care unit patients
- Neonatal outcomes in triplet pregnancies: assisted reproduction versus spontaneous conception
- Sequela of preterm versus term infants born to mothers on a methadone maintenance program: differential course of neonatal abstinence syndrome
- Vacuum extraction and autonomic balance in human infants
- Accuracy of second trimester fetal head circumference and biparietal diameter for predicting the time of spontaneous birth
- Reply
- Induction of labor with oral misoprostol for premature rupture of membranes at term in women with unfavorable cervix
- Reply
- In memoriam: Prof. Shouichi Sakamoto
- Congress Calendar
