Role of visfatin, insulin-like growth factor-I and insulin in fetal growth
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Despina D. Briana
Abstract
Objective: IGF-I and insulin are the main regulators of intrauterine and postnatal growth. Adipose tissue secreted cytokines are implicated in intrauterine growth. The relevant function of the adipocytokine visfatin is unknown.
Materials and methods: Serum visfatin, IGF-I and insulin levels were measured by enzyme immunoassays in 40 singleton full-term fetuses and neonates on postnatal days 1(N1) and 4 (N4).
Results: No significant correlations exist between visfatin and IGF-I or insulin. N1 and N4 visfatin positively correlated with customized (adjusted) birth weight centiles (r=0.511, P=0.021, and r=0.597, P=0.005, respectively). Fetal and N1 IGF-I positively correlated with customized centiles (r=0.608, P<0.001 and r=0.485, P=0.006, respectively). Fetal insulin positively correlated with customized centiles (r=0.654, P=0.021).
Conclusions: Potential implication of visfatin in fetal growth is probably not mediated by IGF-I or insulin. Although a more active role cannot be excluded, visfatin may simply represent a marker of fat accumulation.
©2007 by Walter de Gruyter Berlin New York
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- Umbilical cord blood collection: do patients really understand?
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- Role of visfatin, insulin-like growth factor-I and insulin in fetal growth
- Dynamic QT/RR relationship of cardiac conduction in premature infants treated with low-dose doxapram hydrochloride
- Risk factors and outcomes for ventilator-associated pneumonia in neonatal intensive care unit patients
- Neonatal outcomes in triplet pregnancies: assisted reproduction versus spontaneous conception
- Sequela of preterm versus term infants born to mothers on a methadone maintenance program: differential course of neonatal abstinence syndrome
- Vacuum extraction and autonomic balance in human infants
- Accuracy of second trimester fetal head circumference and biparietal diameter for predicting the time of spontaneous birth
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- Reply
- In memoriam: Prof. Shouichi Sakamoto
- Congress Calendar
Articles in the same Issue
- WAPM-Newsletter No 1/2007 8th WORLD CONGRESS OF PERINATAL MEDICINE in Florence, Italy, September 9–13, 2007
- Poverty and perinatal health
- Maternal mortality in Africa
- Lessons learned from four advanced abdominal pregnancies at an East African Health Center
- Incidence and correlates of cesarean section in a capital city of a middle-income country
- Metabolic changes, hypothalamo-pituitary-adrenal axis and oxidative stress after short-term starvation in healthy pregnant women
- Does maternal docosahexaenoic acid supplementation during pregnancy and lactation lower BMI in late infancy?
- Feasibility of a randomized controlled trial testing nifedipine vs. placebo for the treatment of preterm labor
- Atosiban versus usual care for the management of preterm labor
- Umbilical cord blood collection: do patients really understand?
- Comparison between singleton- and triplet-specific “growth” curves to detect growth restricted triplet infants
- Role of visfatin, insulin-like growth factor-I and insulin in fetal growth
- Dynamic QT/RR relationship of cardiac conduction in premature infants treated with low-dose doxapram hydrochloride
- Risk factors and outcomes for ventilator-associated pneumonia in neonatal intensive care unit patients
- Neonatal outcomes in triplet pregnancies: assisted reproduction versus spontaneous conception
- Sequela of preterm versus term infants born to mothers on a methadone maintenance program: differential course of neonatal abstinence syndrome
- Vacuum extraction and autonomic balance in human infants
- Accuracy of second trimester fetal head circumference and biparietal diameter for predicting the time of spontaneous birth
- Reply
- Induction of labor with oral misoprostol for premature rupture of membranes at term in women with unfavorable cervix
- Reply
- In memoriam: Prof. Shouichi Sakamoto
- Congress Calendar
