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Comparison between singleton- and triplet-specific “growth” curves to detect growth restricted triplet infants

  • Mirit Shoshani , Debbie J. Rhea , Louis G. Keith and Isaac Blickstein
Published/Copyright: July 5, 2007
Journal of Perinatal Medicine
From the journal Volume 35 Issue 4

Abstract

Objective: To evaluate whether triplet- or singleton-specific growth standards should be used to define the growth restricted triplet fetus/neonate.

Study design: We retrospectively compared the predictive values of singleton vs. triplet-specific “growth” standards using the neonatal ponderal index as reference for growth restriction.

Results: A ponderal index <1 SD from the mean was found in 356 (14.4%) of 2477 triplet infants. A total of 686 (27.7%) infants were small for gestational age (SGA) by singleton standards, but only 168 (6.8%) by triplet standards. After 31 weeks' gestation, triplet standards are significantly better associated with a low ponderal index (OR 2.0, 95% CI 1.1, 3.4 at 32 weeks to OR 4.1, 95% CI 2.8, 6.3 at 36–37 weeks), resulting in better positive predictive value and higher specificity of triplet standards in predicting a low ponderal index.

Conclusion: Triplet birth weight standards are better than singleton standards at >31 but not at ≤31 weeks' gestation in predicting a low neonatal ponderal index.


Corresponding author: Isaac Blickstein, MD Department of Obstetrics and Gynecology Kaplan Medical Center Rehovot 76100 Israel

Received: 2006-12-17
Revised: 2007-3-13
Accepted: 2007-3-26
Published Online: 2007-07-05
Published in Print: 2007-8-1

©2007 by Walter de Gruyter Berlin New York

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