Prenatal diagnosis of hemifacial microsomia by magnetic resonance imaging
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Yoshihisa Hattori
Abstract
We present a case of hemifacial microsomia, first detected by prenatal sonography and confirmed by ultrafast magnetic resonance (MR) imaging. A 26-year-old patient was referred to our hospital at 20 weeks of gestation because of unilateral right-sided ventriculomegaly and of a possible ventriculoseptal defect (VSD). Our sonographic examination suggested a right orbital hypoplasia and a hemiatrophy of the nose. The ultrafast T2-weighted single-shot fast-spin echo MR imaging, demonstrated a right ear hypoplasia (microtia), a right orbital hypoplasia, and a right renal hypoplasia. Epibulbar dermoid or conjunctival lipodermoid were not recognized. The fetus was prenatally diagnosed as hemifacial microsomia. Termination of pregnancy was performed at 21 weeks gestation, and a male baby weighing 342g was stillborn. The baby showed facial asymmetry, including hemiatrophy of the right nose, and right ear hypoplasia. Autopsy revealed a 2mm area of VSD, agenesis of the right kidney and ureter, pancreatic and renal aberration into right adrenal gland, thymus hypoplasia and an unfixed ascending colon without intestinal malrotation. To the best of our knowledge, this is the first report of prenatal diagnosis for hemifacial microsomia using fetal MR imaging. In our case, fetal MR imaging has evolved into a powerful diagnostic tool, for the accurate prenatal diagnosis.
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©2005 by Walter de Gruyter Berlin New York
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Articles in the same Issue
- Global approach to perinatal medicine: functional genomics and proteomics
- Fetal and maternal Doppler velocimetry and cytokines in high-risk pregnancy
- IL-8 concentrations in maternal serum, amniotic fluid and cord blood in relation to different pathogens within the amniotic cavity
- Placental pathology and pregnancy outcomes in donor and non-donor oocyte in vitro fertilization pregnancies
- Blink-startle reflex habituation in 30–34-week low-risk fetuses
- Analysis of fetal breathing movements at 30–38 weeks of gestation
- Influence of perinatal factors on hematological variables in umbilical cord blood
- The potential of four-dimensional (4D) ultrasonography in the assessment of fetal awareness
- Early prognostic significance of umbilical cord troponin I in critically ill newborns. Prospective study with a control group
- Is the use of early nasal CPAP associated with lower rates of chronic lung disease and retinopathy of prematurity? Nine years of experience with the Vermont Oxford Neonatal Network
- Fetal growth restriction associated with measles virus infection during pregnancy
- Prenatal diagnosis of hemifacial microsomia by magnetic resonance imaging
- Mega-dose carbamazepine complicating third trimester of pregnancy
- Meconium peritonitis secondary to torsion of fallopian tube cyst and transient central diabetes insipidus in a preterm infant
- Congenital syphilis: β2-microglobulin in cerebrospinal fluid and diagnosis of neurosyphilis in an affected newborn
- Normalization of a severely abnormal ductus venosus Doppler flow velocity waveform in the presence of normal arterial flow parameters
