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IL-8 concentrations in maternal serum, amniotic fluid and cord blood in relation to different pathogens within the amniotic cavity

  • Armin Witt , Angelika Berger , Christian J. Gruber , Ljubomir Petricevic , Petra Apfalter and Peter Husslein
Published/Copyright: June 1, 2005
Journal of Perinatal Medicine
From the journal Volume 33 Issue 1

Abstract

Objective: The association between elevated interleukin (IL)-8 concentrations in amniotic fluid and preterm delivery is well described. Little consideration has been given to the impact of different groups of microorganisms within the amniotic cavity on IL-8 concentration.

Methods: We collected amniotic fluid, placental tissue and amniotic membranes during preterm cesarean sections for bacterial culture. In addition, we determined IL-8 concentrations in maternal serum, amniotic fluid and cord blood and correlated them with the various intra-amniotic pathogens isolated by bacterial culture.

Results: IL-8 concentrations were determined in amniotic fluid in 107 cases, in cord blood in 185 cases and in maternal blood in 158 cases. Women with intra-amniotic Ureaplasma urealyticum infection had significantly higher amniotic fluid concentrations of IL-8 than those without (P<0.001). In cord blood, we found significantly elevated IL-8 concentrations due to intra-amniotic infection with U. urealyticum (P=0.045) and other pathogens (P=0.04). In maternal sera, we found no significant elevation of maternal IL-8 in any of the groups.

Conclusion: Intrauterine infection with U. urealyticum seems to play a profound role in the cascade of inflammation and increases IL-8 concentrations in amniotic fluid and cord blood.

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Corresponding author: Armin Witt, MD, University of Vienna Medical School, Department of Obstetrics and Gynecology, Währinger Gürtel 18-20, A -1090 Vienna/Austria. Tel.: +43-1-40400-2822; Fax.: +43-1-40400-2861;

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Published Online: 2005-06-01
Published in Print: 2005-01-01

©2005 by Walter de Gruyter Berlin New York

Articles in the same Issue

  1. Global approach to perinatal medicine: functional genomics and proteomics
  2. Fetal and maternal Doppler velocimetry and cytokines in high-risk pregnancy
  3. IL-8 concentrations in maternal serum, amniotic fluid and cord blood in relation to different pathogens within the amniotic cavity
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  13. Mega-dose carbamazepine complicating third trimester of pregnancy
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  15. Congenital syphilis: β2-microglobulin in cerebrospinal fluid and diagnosis of neurosyphilis in an affected newborn
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