Startseite Global approach to perinatal medicine: functional genomics and proteomics
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Global approach to perinatal medicine: functional genomics and proteomics

  • Marijeta Kralj , Sandra Kraljević , Mirela Sedić , Asim Kurjak und Krešimir Pavelić
Veröffentlicht/Copyright: 1. Juni 2005
Journal of Perinatal Medicine
Aus der Zeitschrift Band 33 Heft 1

Abstract

Functional genomics (transcriptomics and proteomics) is a global, systematic and comprehensive approach to the identification and description of the processes and pathways involved in normal and abnormal physiological states. The functional genomics methods most applied today are DNA microarrays and proteomics methods, primarily two-dimensional gel electrophoresis coupled with mass spectrometry. To date, interesting research has been carried out, representing milestones for future implementation of functional genomics/proteomics in perinatal medicine. For instance, possible biomarkers of pre-eclampsia, preterm labor and gestational trophoblastic diseases have been discovered. Further systematic examination of differentially regulated genes and proteins in maternal and fetal tissues and fluids will be required. However, high-throughput technologies reflect biological fluctuations and methodological errors. Large amounts of such different data challenge the performance and capacity of the statistical tools and software available at present. Further major developments in this field are pending and the intellectual investment will certainly result in clinical advances.

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Corresponding author: Marijeta Kralj, PhD, Rudjer Bošković Institute, Division of Molecular Medicine, Laboratory of Functional Genomics, Bijenička c. 54 P.O. Box 180, HR-10002 Zagreb/Croatia. Tel.: +385-1-4571235; Fax.: +385-1-4561010;

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Published Online: 2005-06-01
Published in Print: 2005-01-01

©2005 by Walter de Gruyter Berlin New York

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