Global approach to perinatal medicine: functional genomics and proteomics
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Marijeta Kralj
Abstract
Functional genomics (transcriptomics and proteomics) is a global, systematic and comprehensive approach to the identification and description of the processes and pathways involved in normal and abnormal physiological states. The functional genomics methods most applied today are DNA microarrays and proteomics methods, primarily two-dimensional gel electrophoresis coupled with mass spectrometry. To date, interesting research has been carried out, representing milestones for future implementation of functional genomics/proteomics in perinatal medicine. For instance, possible biomarkers of pre-eclampsia, preterm labor and gestational trophoblastic diseases have been discovered. Further systematic examination of differentially regulated genes and proteins in maternal and fetal tissues and fluids will be required. However, high-throughput technologies reflect biological fluctuations and methodological errors. Large amounts of such different data challenge the performance and capacity of the statistical tools and software available at present. Further major developments in this field are pending and the intellectual investment will certainly result in clinical advances.
References
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Artikel in diesem Heft
- Global approach to perinatal medicine: functional genomics and proteomics
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Artikel in diesem Heft
- Global approach to perinatal medicine: functional genomics and proteomics
- Fetal and maternal Doppler velocimetry and cytokines in high-risk pregnancy
- IL-8 concentrations in maternal serum, amniotic fluid and cord blood in relation to different pathogens within the amniotic cavity
- Placental pathology and pregnancy outcomes in donor and non-donor oocyte in vitro fertilization pregnancies
- Blink-startle reflex habituation in 30–34-week low-risk fetuses
- Analysis of fetal breathing movements at 30–38 weeks of gestation
- Influence of perinatal factors on hematological variables in umbilical cord blood
- The potential of four-dimensional (4D) ultrasonography in the assessment of fetal awareness
- Early prognostic significance of umbilical cord troponin I in critically ill newborns. Prospective study with a control group
- Is the use of early nasal CPAP associated with lower rates of chronic lung disease and retinopathy of prematurity? Nine years of experience with the Vermont Oxford Neonatal Network
- Fetal growth restriction associated with measles virus infection during pregnancy
- Prenatal diagnosis of hemifacial microsomia by magnetic resonance imaging
- Mega-dose carbamazepine complicating third trimester of pregnancy
- Meconium peritonitis secondary to torsion of fallopian tube cyst and transient central diabetes insipidus in a preterm infant
- Congenital syphilis: β2-microglobulin in cerebrospinal fluid and diagnosis of neurosyphilis in an affected newborn
- Normalization of a severely abnormal ductus venosus Doppler flow velocity waveform in the presence of normal arterial flow parameters