Placental pathology and pregnancy outcomes in donor and non-donor oocyte in vitro fertilization pregnancies
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Sriram C. Perni
Abstract
Objective: Intrinsically poor maternal adaptation to pregnancy and dysregulated processes have been postulated to occur as a consequence of an immune response to the feto-placental unit as “foreign” material. The aim of our study was to compare placental pathology and pregnancy outcomes of in vitro fertilization (IVF) pregnancies conceived by donor oocytes with those conceived by non-donor oocytes.
Study design: We conducted a retrospective, case-control study on 91 placentas from IVF pregnancies (36 from donor oocytes and 55 from non-donor cycles). All placentas were examined by a single pathologist for signs indicative of an immune response, including chronic villitis, chronic deciduitis, increased perivillous fibrin, ischemic change/infarction, decidual vasculopathy, increased syncytial knots, intervillous thrombi, and retroplacental hematomas.
Results: Placentas from donor cycles were significantly more likely to demonstrate certain pathologic findings: chronic villitis (P<0.001), chronic deciduitis (P=0.034), increased perivillous fibrin (P=0.001), ischemic change/infarction (P=0.001), and intervillous thrombi (P=0.008). There was no statistical significance with respect to decidual vasculopathy, increased syncytial knots, or retroplacental hematomas.
Conclusion: Pathologic evidence of an immune-mediated process is much more pronounced in donor oocyte IVF pregnancies compared to non-donor cycles. Clinical implications of these findings have yet to be determined.
References
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©2005 by Walter de Gruyter Berlin New York
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Articles in the same Issue
- Global approach to perinatal medicine: functional genomics and proteomics
- Fetal and maternal Doppler velocimetry and cytokines in high-risk pregnancy
- IL-8 concentrations in maternal serum, amniotic fluid and cord blood in relation to different pathogens within the amniotic cavity
- Placental pathology and pregnancy outcomes in donor and non-donor oocyte in vitro fertilization pregnancies
- Blink-startle reflex habituation in 30–34-week low-risk fetuses
- Analysis of fetal breathing movements at 30–38 weeks of gestation
- Influence of perinatal factors on hematological variables in umbilical cord blood
- The potential of four-dimensional (4D) ultrasonography in the assessment of fetal awareness
- Early prognostic significance of umbilical cord troponin I in critically ill newborns. Prospective study with a control group
- Is the use of early nasal CPAP associated with lower rates of chronic lung disease and retinopathy of prematurity? Nine years of experience with the Vermont Oxford Neonatal Network
- Fetal growth restriction associated with measles virus infection during pregnancy
- Prenatal diagnosis of hemifacial microsomia by magnetic resonance imaging
- Mega-dose carbamazepine complicating third trimester of pregnancy
- Meconium peritonitis secondary to torsion of fallopian tube cyst and transient central diabetes insipidus in a preterm infant
- Congenital syphilis: β2-microglobulin in cerebrospinal fluid and diagnosis of neurosyphilis in an affected newborn
- Normalization of a severely abnormal ductus venosus Doppler flow velocity waveform in the presence of normal arterial flow parameters
