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High-sensitive troponin T in chronic heart failure correlates with severity of symptoms, left ventricular dysfunction and prognosis independently from N-terminal pro-b-type natriuretic peptide
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Carsten G. Jungbauer
Veröffentlicht/Copyright:
6. September 2011
Abstract
Background: Troponin T is an established marker of myocardial ischemia. We speculated that the role of the new high-sensitive troponin T (hs-cTnT) might expand towards non-ischemic myocardial disease, indicate disease severity and allow for prognostication in chronic heart failure.
Methods: Hs-cTnT (Roche Diagnostics, Mannheim, Germany) was assessed in 233 individuals with chronic heart failure (n=149) or healthy controls (n=84).
Results: Hs-cTnT was significantly elevated in patients with chronic heart failure [0.018 ng/mL, interquartile range (IQR) 0.009–0.036 ng/mL, vs. controls 0.003 ng/mL, 0.003–0.003 ng/mL, p<0.001] and positively correlated with N-terminal pro-b-type natriuretic peptide (NT-proBNP) (r=0.79, p<0.001). Hs-cTnT increased stepwise and signitificantly according to clinical (NYHA stage) as well as functional (LV ejection fraction, fluid retention) severity (each p<0.001). At a binary cutpoint of 0.014 ng/mL, hs-TropT was a significant predictor of all-cause mortality and all-cause mortality or rehospitalization for congestive heart failure (each p≤0.01). Of note, the prognostic value of hs-TropT was independent and additive to that of NT-proBNP.
Conclusions: Hs-cTnT increases stepwise with the severity of symptoms and LV dysfunction and offers important prognostic information in chronic heart failure, independently from and additive to NT-proBNP. The utility of hs-cTnT expands beyond acute myocardial ischemia and towards chronic heart failure.
Received: 2011-1-3
Accepted: 2011-7-25
Published Online: 2011-09-6
Published in Print: 2011-11-01
©2011 by Walter de Gruyter Berlin Boston
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Schlagwörter für diesen Artikel
cardiac markers;
chronic heart failure;
high-sensitive troponin T;
natriuretic peptides
Artikel in diesem Heft
- Editorial
- Thank you, indeed!
- Reviews
- Glomerular filtration rate estimation: performance of serum cystatin C-based prediction equations
- Oxidative stress and diabetes mellitus
- Human papilloma virus (HPV) molecular diagnostics
- Opinion Papers
- Urine immunofixation electrophoresis remains important and is complementary to serum free light chain
- Permissible performance limits of regression analyses in method comparisons
- General Clinical Chemistry and Laboratory Medicine
- The value of serum ischemia-modified albumin for assessing liver function in patients with chronic liver disease
- Relationship between bilirubin and C-reactive protein
- Status of serum-calcium and -albumin measurement in Argentina assessed in 300 representative laboratories with 20 fresh frozen single donation sera
- Practical application of Sigma Metrics QC procedures in clinical chemistry
- High-throughput analysis of testosterone in serum samples by on-line solid phase extraction liquid chromatography-tandem mass spectrometry
- Monitoring of mycophenolic acid and kidney function during combined immunosuppressive therapy
- Phenotype of Gc-globulin influences the macrophage activating factor (MAF) levels in serum
- Combination of cellular population data and CytoDiff™ analyses for the diagnosis of lymphocytosis
- Eosinophiluria is common among patients after ileal conduit surgery
- Soluble urokinase plasminogen activator receptor (suPAR) levels in healthy pregnancy and preeclampsia
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