Article
Licensed
Unlicensed
Requires Authentication
Glomerular filtration rate estimation: performance of serum cystatin C-based prediction equations
-
Letícia Schwerz Weinert
Published/Copyright:
July 14, 2011
Abstract
Serum creatinine measurement is a mainstay in the routine laboratory evaluation of renal function, despite of having several disadvantages. Cystatin C, on the other hand, suffers less influence of gender and muscle mass and has been proposed as a more sensitive marker for glomerular filtration rate. However, serum endogenous markers should not be used alone to assess glomerular filtration rate. Creatinine-based equations such as the modification of diet in renal disease (MDRD) and Cockcroft-Gault are widely used despite their limitations. A large number of cystatin C-based prediction equations were developed in recent years, in diverse populations, with different laboratory assays and methods. Several studies demonstrated that cystatin C-based equations are reliable markers of glomerular filtration rate and can be used for diagnosis, evaluation and follow-up of kidney disease. They are simpler than creatinine-based equations and have at least the same accuracy and precision for glomerular filtration rate estimation. In conclusion, diabetes mellitus, cystic fibrosis, kidney transplantation, HIV-infection, and cirrhosis are clinical situations where cystatin C-based equations can be useful. Extremes of age such as childhood and advanced age have also been evaluated with favorable results.
Received: 2011-4-20
Accepted: 2011-6-21
Published Online: 2011-07-14
Published in Print: 2011-11-01
©2011 by Walter de Gruyter Berlin Boston
You are currently not able to access this content.
You are currently not able to access this content.
Articles in the same Issue
- Editorial
- Thank you, indeed!
- Reviews
- Glomerular filtration rate estimation: performance of serum cystatin C-based prediction equations
- Oxidative stress and diabetes mellitus
- Human papilloma virus (HPV) molecular diagnostics
- Opinion Papers
- Urine immunofixation electrophoresis remains important and is complementary to serum free light chain
- Permissible performance limits of regression analyses in method comparisons
- General Clinical Chemistry and Laboratory Medicine
- The value of serum ischemia-modified albumin for assessing liver function in patients with chronic liver disease
- Relationship between bilirubin and C-reactive protein
- Status of serum-calcium and -albumin measurement in Argentina assessed in 300 representative laboratories with 20 fresh frozen single donation sera
- Practical application of Sigma Metrics QC procedures in clinical chemistry
- High-throughput analysis of testosterone in serum samples by on-line solid phase extraction liquid chromatography-tandem mass spectrometry
- Monitoring of mycophenolic acid and kidney function during combined immunosuppressive therapy
- Phenotype of Gc-globulin influences the macrophage activating factor (MAF) levels in serum
- Combination of cellular population data and CytoDiff™ analyses for the diagnosis of lymphocytosis
- Eosinophiluria is common among patients after ileal conduit surgery
- Soluble urokinase plasminogen activator receptor (suPAR) levels in healthy pregnancy and preeclampsia
- Uptake of cobalamin and markers of cobalamin status: a longitudinal study of healthy pregnant women
- Vitamin B12 absorption judged by measurement of holotranscobalamin, active vitamin B12: evaluation of a commercially available EIA kit
- Salivary markers of oxidative stress and Salivette collection systems
- Infectious Diseases
- Development of a microwell adapted immunoblot system with recombinant antigens for distinguishing human herpesvirus (HHV)6A and HHV6B and detection of human cytomegalovirus
- Cardiovascular Disease
- High-sensitive troponin T in chronic heart failure correlates with severity of symptoms, left ventricular dysfunction and prognosis independently from N-terminal pro-b-type natriuretic peptide
- Plasma symmetric dimethylarginine reference limits from the Framingham offspring cohort
- Letters to the Editor
- Iron deficiency prevalence is increased among Helicobacter pylori infected Brazilian patients
- Helicobacter pylori infection and iron deficiency in a group of Brazilian patients
- Multiplex protein assay performance/evaluation and the requirement for precision and correlation to clinical assays
- Functional assay or antigen test for protein C and protein S in ischemic stroke: which shows the greatest change?
Keywords for this article
cystatin C;
equation;
glomerular filtration rate;
kidney disease;
kidney function
Articles in the same Issue
- Editorial
- Thank you, indeed!
- Reviews
- Glomerular filtration rate estimation: performance of serum cystatin C-based prediction equations
- Oxidative stress and diabetes mellitus
- Human papilloma virus (HPV) molecular diagnostics
- Opinion Papers
- Urine immunofixation electrophoresis remains important and is complementary to serum free light chain
- Permissible performance limits of regression analyses in method comparisons
- General Clinical Chemistry and Laboratory Medicine
- The value of serum ischemia-modified albumin for assessing liver function in patients with chronic liver disease
- Relationship between bilirubin and C-reactive protein
- Status of serum-calcium and -albumin measurement in Argentina assessed in 300 representative laboratories with 20 fresh frozen single donation sera
- Practical application of Sigma Metrics QC procedures in clinical chemistry
- High-throughput analysis of testosterone in serum samples by on-line solid phase extraction liquid chromatography-tandem mass spectrometry
- Monitoring of mycophenolic acid and kidney function during combined immunosuppressive therapy
- Phenotype of Gc-globulin influences the macrophage activating factor (MAF) levels in serum
- Combination of cellular population data and CytoDiff™ analyses for the diagnosis of lymphocytosis
- Eosinophiluria is common among patients after ileal conduit surgery
- Soluble urokinase plasminogen activator receptor (suPAR) levels in healthy pregnancy and preeclampsia
- Uptake of cobalamin and markers of cobalamin status: a longitudinal study of healthy pregnant women
- Vitamin B12 absorption judged by measurement of holotranscobalamin, active vitamin B12: evaluation of a commercially available EIA kit
- Salivary markers of oxidative stress and Salivette collection systems
- Infectious Diseases
- Development of a microwell adapted immunoblot system with recombinant antigens for distinguishing human herpesvirus (HHV)6A and HHV6B and detection of human cytomegalovirus
- Cardiovascular Disease
- High-sensitive troponin T in chronic heart failure correlates with severity of symptoms, left ventricular dysfunction and prognosis independently from N-terminal pro-b-type natriuretic peptide
- Plasma symmetric dimethylarginine reference limits from the Framingham offspring cohort
- Letters to the Editor
- Iron deficiency prevalence is increased among Helicobacter pylori infected Brazilian patients
- Helicobacter pylori infection and iron deficiency in a group of Brazilian patients
- Multiplex protein assay performance/evaluation and the requirement for precision and correlation to clinical assays
- Functional assay or antigen test for protein C and protein S in ischemic stroke: which shows the greatest change?
