Polymorphisms of the β1-adrenergic receptor gene are associated with essential hypertension in Chinese
-
Yingxin Peng
Abstract
Background: The β1-adrenergic receptor (ADRB1) plays a pivotal role in mediating signal transduction of the sympathetic-adrenal system, which is involved in the regulation of cardiac output and peripheral resistance. Our goal was to determine whether the polymorphisms Arg389Gly (rs1801253) and Ser49Gly (rs1801252) of the ADRB1 gene were associated with essential hypertension in Chinese.
Methods: We tested our hypothesis in two independent case-control studies, one comprised 481 patients with hypertension and 529 control subjects, and the other study comprised 212 patients and 325 control subjects. All subjects were genotyped for Arg389Gly and Ser49Gly polymorphisms.
Results: The first study showed that the Arg389Arg genotype of the ADRB1 gene was associated with risk of hypertension [odds ratio (OR) 1.77, 95% confidence interval (CI) 1.09–2.98; p=0.008], and the association was replicated in the second independent population (OR 1.65, 95% CI 1.07–2.89, p=0.01). The patients with the Arg389Arg genotype had significantly higher diastolic blood pressure (DBP) than did those with Arg389Gly genotype as well as those with Gly389Gly genotype (100.29±11.01 mm Hg vs. 95.33±13.10 mm Hg and vs. 96.17±12.18 mm Hg, respectively, p=0.01, p=0.02). The association was replicated in the second study (103.7±13.3 mm Hg vs. 97.31±12.9 mm Hg and vs. 96.29±13.4 mm Hg, respectively, p=0.03, p=0.02). Heart rate also showed an association (in first study: 79.43±9.90 bpm vs. 74.87±8.96 bpm, vs. 73.92±8.18 bpm, respectively, p=0.02, p=0.014; in the second study: 81.12±8.99 bpm vs. 74.85±7.97 bpm and vs. 73.89±9.12 bpm, p=0.007, p=0.006, respectively). No association was seen between systolic blood pressure (SBP) and any of the three genotypes at amino acid position 389 in hypertensive patients, neither between the Ser49Gly polymorphisms and hypertension, nor between the Ser49Gly genotypes and DBP and heart rate.
Conclusions: The polymorphisms of the ADRB1 gene were associated with essential hypertension. The Arg389Gly polymorphism of the ADRB1 gene confers higher risk for hypertension.
Clin Chem Lab Med 2009;47:1227–31.
©2009 by Walter de Gruyter Berlin New York
Artikel in diesem Heft
- Editorial
- Cardiac troponins: what we knew, what we know – where are we now?
- Review
- Measurement of circulating concentrations of cardiac troponin I and T in healthy subjects: a tool for monitoring myocardial tissue renewal?
- Opinion Papers
- A critical appraisal of experimental factors influencing the definition of the 99th percentile limit for cardiac troponins
- Genetic and biochemical heterogeneity of cardiac troponins: clinical and laboratory implications
- The future of hospital laboratories. Position statement from the Royal Belgian Society of Clinical Chemistry (RBSCC)
- Point
- Quantity quotient reporting. A proposal for a standardized presentation of laboratory results
- Counterpoint
- Quantity quotient reporting. Counterpoint
- Perspectives
- Increasing laboratory medicine activities in China: research and publications
- Contributions in Biochemistry and Molecular Biology from China and other top-ranking countries: a 10-year survey of the literature
- Genetics and Molecular Diagnostics
- SOCS3 and IRS-1 gene expression differs between genotype 1 and genotype 2 hepatitis C virus-infected HepG2 cells
- Polymorphisms of the β1-adrenergic receptor gene are associated with essential hypertension in Chinese
- Egyptian glycogen storage disease type III – identification of six novel AGL mutations, including a large 1.5 kb deletion and a missense mutation p.L620P with subtype IIId
- Novel rare alleles of ABCA1 are exclusively associated with extreme high-density lipoprotein-cholesterol levels among the Han Chinese
- –308G>A and –1031T>C tumor necrosis factor gene polymorphisms in Tunisian patients with coronary artery disease
- General Clinical Chemistry and Laboratory Medicine
- Error tracking in a clinical biochemistry laboratory
- HbA1c measurements from dried blood spots: validation and patient satisfaction
- Pre-transplant serum concentrations of anti-endothelial cell antibody in panel reactive antibody negative renal recipients and its impact on acute rejection
- Cancer Diagnostics
- Detection of Meningeosis neoplastica by real-time quantitation of telomerase activity
- The prognostic utility of haptoglobin genotypes in squamous cell carcinoma of the head and neck
- Evaluation of a new method for the diagnosis of alterations of Lens culinaris agglutinin binding of thyroglobulin molecules in thyroid carcinoma
- The soluble transferrin receptor (TfR)-F-Index is not applicable as a test for iron status in patients with chronic lymphocytic leukemia
- Impact of calibration fitting models on the clinical value of chromogranin A
- Letters to the Editor
- Clinical value of a competitive NT-proBNP enzyme immunoassay compared to the Roche NT-proBNP platform
- Should gender-related reference values be used for total bilirubin?
- A novel nonsense mutation in the albumin gene (c.1275 C>A) causing analbuminemia in a Tunisian boy
- Abstracts
- 41st National Congress of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology, 2nd Joint National Event SIBioC-SIMeL
Artikel in diesem Heft
- Editorial
- Cardiac troponins: what we knew, what we know – where are we now?
- Review
- Measurement of circulating concentrations of cardiac troponin I and T in healthy subjects: a tool for monitoring myocardial tissue renewal?
- Opinion Papers
- A critical appraisal of experimental factors influencing the definition of the 99th percentile limit for cardiac troponins
- Genetic and biochemical heterogeneity of cardiac troponins: clinical and laboratory implications
- The future of hospital laboratories. Position statement from the Royal Belgian Society of Clinical Chemistry (RBSCC)
- Point
- Quantity quotient reporting. A proposal for a standardized presentation of laboratory results
- Counterpoint
- Quantity quotient reporting. Counterpoint
- Perspectives
- Increasing laboratory medicine activities in China: research and publications
- Contributions in Biochemistry and Molecular Biology from China and other top-ranking countries: a 10-year survey of the literature
- Genetics and Molecular Diagnostics
- SOCS3 and IRS-1 gene expression differs between genotype 1 and genotype 2 hepatitis C virus-infected HepG2 cells
- Polymorphisms of the β1-adrenergic receptor gene are associated with essential hypertension in Chinese
- Egyptian glycogen storage disease type III – identification of six novel AGL mutations, including a large 1.5 kb deletion and a missense mutation p.L620P with subtype IIId
- Novel rare alleles of ABCA1 are exclusively associated with extreme high-density lipoprotein-cholesterol levels among the Han Chinese
- –308G>A and –1031T>C tumor necrosis factor gene polymorphisms in Tunisian patients with coronary artery disease
- General Clinical Chemistry and Laboratory Medicine
- Error tracking in a clinical biochemistry laboratory
- HbA1c measurements from dried blood spots: validation and patient satisfaction
- Pre-transplant serum concentrations of anti-endothelial cell antibody in panel reactive antibody negative renal recipients and its impact on acute rejection
- Cancer Diagnostics
- Detection of Meningeosis neoplastica by real-time quantitation of telomerase activity
- The prognostic utility of haptoglobin genotypes in squamous cell carcinoma of the head and neck
- Evaluation of a new method for the diagnosis of alterations of Lens culinaris agglutinin binding of thyroglobulin molecules in thyroid carcinoma
- The soluble transferrin receptor (TfR)-F-Index is not applicable as a test for iron status in patients with chronic lymphocytic leukemia
- Impact of calibration fitting models on the clinical value of chromogranin A
- Letters to the Editor
- Clinical value of a competitive NT-proBNP enzyme immunoassay compared to the Roche NT-proBNP platform
- Should gender-related reference values be used for total bilirubin?
- A novel nonsense mutation in the albumin gene (c.1275 C>A) causing analbuminemia in a Tunisian boy
- Abstracts
- 41st National Congress of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology, 2nd Joint National Event SIBioC-SIMeL
