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Glomerular filtration rate measurement and prediction equations
-
Ariana Aguiar Soares
Veröffentlicht/Copyright:
1. September 2009
Abstract
Chronic kidney disease (CKD) is defined as the presence of kidney damage or a glomerular filtration rate (GFR) <60 mL/min/1.73 m2 for three or more months. Measurement of serum creatinine is the most commonly used method to evaluated kidney function, but it must be included in formulas to estimate GFR, adjusting for age, gender and ethnicity, such as the Modification of Diet in Renal Disease (MDRD) study equation. The performance of this equation is acceptable for patients with CKD but appears to under-estimate GFR in populations with unknown kidney status. A new formula has been developed recently. The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation appears to perform better than the MDRD equation. Cystatin C has been widely evaluated as a marker for GFR and seems to be more sensitive than creatinine. The aim of this review is to discuss the recommendations for detecting CKD, emphasizing the characteristics and limitations of GFR estimating equations and pitfalls in the evaluation of urinary albumin excretion.
Clin Chem Lab Med 2009;47:1023–32.
Keywords: chronic kidney disease; Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI); creatinine; glomerular filtration rate; kidney function; Modification of Diet in Renal Disease (MDRD); urinary albumin excretion
Received: 2009-5-11
Accepted: 2009-6-29
Published Online: 2009-09-01
Published in Print: 2009-09-01
©2009 by Walter de Gruyter Berlin New York
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Artikel in diesem Heft
- Editorials
- Estimating glomerular filtration rate
- Serum-free light chain analysis: works in progress
- Review
- Glomerular filtration rate measurement and prediction equations
- Genetics and Molecular Diagnostics
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- Peroxisome proliferator-activated receptor-γ (PPARγ) Pro12Ala polymorphism and risk for pediatric obesity
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- General Clinical Chemistry and Laboratory Medicine
- Relationship of serum bilirubin concentrations to kidney function and albuminuria in the United States adult population. Findings from the National Health and Nutrition Examination Survey 2001–2006
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- A case-control study on the relationship between HDL2b and non-alcoholic fatty liver disease in Chinese type 2 diabetic patients
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