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Pre-treatment serum and plasma levels of matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of matrix metalloproteinases 1 (TIMP-1) in gastric cancer patients
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Barbara Mroczko
Published/Copyright:
September 1, 2009
Abstract
Background: The invasion and metastases of gastric cancer (GC) depends on the activities of matrix metalloproteinases and tissue inhibitors of metalloproteinases. It was suggested that the concentration of plasma matrix metalloproteinase-9 (MMP-9) is better than the concentration of serum MMP-9 for prediction of evolution of GC. The aim of the present study was to compare the clinical usefulness of plasma and serum tissue inhibitor of metalloproteinases-1 (TIMP-1) in the diagnosis and prognosis of GC.
Methods:Plasma and serum concentrations of TIMP-1, MMP-9 and carcinoembryonic antigen (CEA) were assayed in 73 patients with GC and 61 healthy controls. The diagnostic criteria and prognostic value for the measurands were defined.
Results: Plasma and serum TIMP-1, MMP-9 and CEA were significantly higher in GC patients compared with healthy controls. The area under the ROC curve (AUC) (0.961), diagnostic sensitivity (89%) and accuracy (91%) of plasma TIMP-1 were higher than those for MMP-9 and CEA. An increased pre-treatment concentration of plasma TIMP-1 was a significant independent prognostic factor for the survival of patients with GC.
Conclusions: These findings suggest that the plasma TIMP-1 is a better biomarker than the serum TIMP-1 and might be useful for the diagnosis of GC and prognosis of patient survival.
Clin Chem Lab Med 2009;47:1133–9.
Keywords: gastric cancer; matrix metalloproteinase-9; tissue inhibitor of metalloproteinases-1; tumor markers
Received: 2009-5-22
Accepted: 2009-6-16
Published Online: 2009-09-01
Published in Print: 2009-09-01
©2009 by Walter de Gruyter Berlin New York
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Keywords for this article
gastric cancer;
matrix metalloproteinase-9;
tissue inhibitor of metalloproteinases-1;
tumor markers
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