Article
Licensed
Unlicensed
Requires Authentication
Reliability of two different bedside assays for C-reactive protein in newborn infants
-
Enrico Zecca
Published/Copyright:
September 1, 2009
Abstract
Background: Bedside tests for C-reactive protein (CRP) have been studied in pediatric patients, but not in neonates.
Methods: This study compared the results of two rapid bedside tests for CRP (Quick-Read CRP, Orion Diagnostic, Espoo, Finland and NycoCard CRP-Single Test, Axis-Shield, Oslo, Norway) with those of our central laboratory method (CRP-Lab) in newborn infants. CRP concentrations were determined using 72 samples obtained from 43 infants with suspected sepsis occurring between 1 and 28 days of life.
Results: Considering positive CRP concentrations to be ≥10 mg/L, both bedside tests had good specificity (Quick-Read 80.5%, NycoCard 83.3%) and sensitivity (Quick-Read 97.2%, NycoCard 94.4%) when compared with our CRP-Lab. The agreement of measurement with central laboratory values was high for both the bedside tests, without statistically significant differences between the methods. The Quick-Read and NycoCard methods did not show any statistically significant systematic proportional bias when compared with the central laboratory values. The accuracy of the results of both bedside tests is somewhat decreased when CRP concentrations are >100 mg/L.
Conclusions: This study shows that both the Quick-Read and the NycoCard test can be used for serial determinations of CRP concentrations in newborn infants. They require small volumes of blood and provide reliable results in <5 min.
Clin Chem Lab Med 2009;47:1081–4.
Received: 2009-2-20
Accepted: 2009-6-2
Published Online: 2009-09-01
Published in Print: 2009-09-01
©2009 by Walter de Gruyter Berlin New York
You are currently not able to access this content.
You are currently not able to access this content.
Articles in the same Issue
- Editorials
- Estimating glomerular filtration rate
- Serum-free light chain analysis: works in progress
- Review
- Glomerular filtration rate measurement and prediction equations
- Genetics and Molecular Diagnostics
- Leptin gene (TTTC)n microsatellite polymorphism in pre-eclampsia and HELLP syndrome
- TaqIB polymorphism in cholesterol ester transfer protein (CETP) gene predicts future cardiovascular death in patients experiencing an acute coronary syndrome
- Peroxisome proliferator-activated receptor-γ (PPARγ) Pro12Ala polymorphism and risk for pediatric obesity
- Application of pyrosequencing to the identification of sequence variations in the cystic fibrosis transmembrane conductance regulator gene
- General Clinical Chemistry and Laboratory Medicine
- Relationship of serum bilirubin concentrations to kidney function and albuminuria in the United States adult population. Findings from the National Health and Nutrition Examination Survey 2001–2006
- Efficiency of test report delivery to the requesting physician in an outpatient setting: an observational study
- A case-control study on the relationship between HDL2b and non-alcoholic fatty liver disease in Chinese type 2 diabetic patients
- Preeclamptic placental stress and over expression of mitochondrial HSP70
- Reliability of two different bedside assays for C-reactive protein in newborn infants
- Clinical relevance of circulating midkine in ulcerative colitis
- First automated assay for thyrotropin receptor autoantibodies
- Serum concentrations of extracellular fatty acid synthase in patients with steatohepatitis
- Cancer Diagnostics
- Serum free light chains: diagnostic and prognostic value in multiple myeloma
- Quantitation of serum free light chains does not compensate for serum immunofixation only when screening for monoclonal gammopathies
- Serum HER-2 concentrations for monitoring women with breast cancer in a routine oncology setting
- Level of selenoprotein transcripts in peripheral leukocytes of patients with bladder cancer and healthy individuals
- Pre-treatment serum and plasma levels of matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of matrix metalloproteinases 1 (TIMP-1) in gastric cancer patients
- Infectious Disease
- Diagnosis of infection with human herpes viruses in routine laboratory practice
- Isolation and expression of UB05, a Plasmodium falciparum antigen recognised by antibodies from semi-immune adults in a high transmission endemic area of the Cameroonian rainforest
- Letters to the Editor
- Use of EDTA-plasma gel-separating tubes for measurement of indocyanine green
- Composition of cryoglobulin and cryoprecipitate
- Congress Abstracts
- Congress of Clinical Chemistry and Laboratory Medicine. 6th Annual Conference of the German Society for Clinical Chemistry and Laboratory Medicine (DGKL), Leipzig, Germany, October 7–10, 2009
- 8th Panhellenic Clinical Chemistry Congress, Patras, Greece, October 2–4, 2009
Keywords for this article
bedside testing;
C-reactive protein;
newborn infant;
sensitivity and specificity;
sepsis
Articles in the same Issue
- Editorials
- Estimating glomerular filtration rate
- Serum-free light chain analysis: works in progress
- Review
- Glomerular filtration rate measurement and prediction equations
- Genetics and Molecular Diagnostics
- Leptin gene (TTTC)n microsatellite polymorphism in pre-eclampsia and HELLP syndrome
- TaqIB polymorphism in cholesterol ester transfer protein (CETP) gene predicts future cardiovascular death in patients experiencing an acute coronary syndrome
- Peroxisome proliferator-activated receptor-γ (PPARγ) Pro12Ala polymorphism and risk for pediatric obesity
- Application of pyrosequencing to the identification of sequence variations in the cystic fibrosis transmembrane conductance regulator gene
- General Clinical Chemistry and Laboratory Medicine
- Relationship of serum bilirubin concentrations to kidney function and albuminuria in the United States adult population. Findings from the National Health and Nutrition Examination Survey 2001–2006
- Efficiency of test report delivery to the requesting physician in an outpatient setting: an observational study
- A case-control study on the relationship between HDL2b and non-alcoholic fatty liver disease in Chinese type 2 diabetic patients
- Preeclamptic placental stress and over expression of mitochondrial HSP70
- Reliability of two different bedside assays for C-reactive protein in newborn infants
- Clinical relevance of circulating midkine in ulcerative colitis
- First automated assay for thyrotropin receptor autoantibodies
- Serum concentrations of extracellular fatty acid synthase in patients with steatohepatitis
- Cancer Diagnostics
- Serum free light chains: diagnostic and prognostic value in multiple myeloma
- Quantitation of serum free light chains does not compensate for serum immunofixation only when screening for monoclonal gammopathies
- Serum HER-2 concentrations for monitoring women with breast cancer in a routine oncology setting
- Level of selenoprotein transcripts in peripheral leukocytes of patients with bladder cancer and healthy individuals
- Pre-treatment serum and plasma levels of matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of matrix metalloproteinases 1 (TIMP-1) in gastric cancer patients
- Infectious Disease
- Diagnosis of infection with human herpes viruses in routine laboratory practice
- Isolation and expression of UB05, a Plasmodium falciparum antigen recognised by antibodies from semi-immune adults in a high transmission endemic area of the Cameroonian rainforest
- Letters to the Editor
- Use of EDTA-plasma gel-separating tubes for measurement of indocyanine green
- Composition of cryoglobulin and cryoprecipitate
- Congress Abstracts
- Congress of Clinical Chemistry and Laboratory Medicine. 6th Annual Conference of the German Society for Clinical Chemistry and Laboratory Medicine (DGKL), Leipzig, Germany, October 7–10, 2009
- 8th Panhellenic Clinical Chemistry Congress, Patras, Greece, October 2–4, 2009
