Artikel
Lizenziert
Nicht lizenziert
Erfordert eine Authentifizierung
Peroxisome proliferator-activated receptor-γ (PPARγ) Pro12Ala polymorphism and risk for pediatric obesity
-
George V. Dedoussis
Veröffentlicht/Copyright:
27. Juli 2009
Abstract
Background: Variation in the peroxisome-proliferator-activated receptor γ (PPARγ) gene has been reported to alter the risk for adiposity in adults.
Methods: We investigated the gender related association between the Pro12Ala variant (rs1801282) in obesity and insulin resistance traits in 794 peri-adolescent children aged 10–12 years of Greek origin from the Gene and Diet Attica Investigation (GENDAI) cohort.
Results: Gender stratified analysis suggested that in peri-adolescent boys, Ala carriers exhibited lower measures of skinfold (triceps: 16.9±6.9 vs. 19.4±7.9 mm, p=0.014; subscapular: 9.6±4.5 vs. 11.2±5.4 mm, p=0.016) and lower adiponectin concentrations (3.9±1.3 vs. 4.7±2.4 μg/mL, p=0.05). In peri-adolescent girls, Ala carriers had lower insulin concentrations (7.3±3.7 vs. 8.5±4.4 μU/mL, p=0.026) and lower values of homeostasis model assessment of insulin resistance (HOMA-IR) (1.5±0.8 vs. 1.8±0.96, p=0.019). Linear regression analysis revealed that the presence of the Ala allele in boys was a nominally significant predictor of obesity indices, including skin-folds (triceps: β±SE: –2.3±1.1, p=0.032; subscapular: β±SE: –2.3±1.1, p=0.04) and adiponectin concentrations (β±SE: –0.7±0.4, p=0.05) after adjusting for potential covariates. In girls, the Ala allele was a predictor of insulin concentrations (β±SE: –1.2±0.6, p=0.037) and HOMA-IR (β±SE: –0.24±0.13, p=0.037).
Conclusions: Our results suggest that adiposity in children is influenced by the Pro12Ala polymorphism in a gender specific manner.
Clin Chem Lab Med 2009;47:1047–50.
Keywords: adiposity; children; diet; gender interaction; obesity; peroxisome proliferator-activated receptor γ (PPARγ); Pro12Ala polymorphism
Received: 2009-4-29
Accepted: 2009-6-16
Published Online: 2009-07-27
Published in Print: 2009-09-01
©2009 by Walter de Gruyter Berlin New York
Sie haben derzeit keinen Zugang zu diesem Inhalt.
Sie haben derzeit keinen Zugang zu diesem Inhalt.
Artikel in diesem Heft
- Editorials
- Estimating glomerular filtration rate
- Serum-free light chain analysis: works in progress
- Review
- Glomerular filtration rate measurement and prediction equations
- Genetics and Molecular Diagnostics
- Leptin gene (TTTC)n microsatellite polymorphism in pre-eclampsia and HELLP syndrome
- TaqIB polymorphism in cholesterol ester transfer protein (CETP) gene predicts future cardiovascular death in patients experiencing an acute coronary syndrome
- Peroxisome proliferator-activated receptor-γ (PPARγ) Pro12Ala polymorphism and risk for pediatric obesity
- Application of pyrosequencing to the identification of sequence variations in the cystic fibrosis transmembrane conductance regulator gene
- General Clinical Chemistry and Laboratory Medicine
- Relationship of serum bilirubin concentrations to kidney function and albuminuria in the United States adult population. Findings from the National Health and Nutrition Examination Survey 2001–2006
- Efficiency of test report delivery to the requesting physician in an outpatient setting: an observational study
- A case-control study on the relationship between HDL2b and non-alcoholic fatty liver disease in Chinese type 2 diabetic patients
- Preeclamptic placental stress and over expression of mitochondrial HSP70
- Reliability of two different bedside assays for C-reactive protein in newborn infants
- Clinical relevance of circulating midkine in ulcerative colitis
- First automated assay for thyrotropin receptor autoantibodies
- Serum concentrations of extracellular fatty acid synthase in patients with steatohepatitis
- Cancer Diagnostics
- Serum free light chains: diagnostic and prognostic value in multiple myeloma
- Quantitation of serum free light chains does not compensate for serum immunofixation only when screening for monoclonal gammopathies
- Serum HER-2 concentrations for monitoring women with breast cancer in a routine oncology setting
- Level of selenoprotein transcripts in peripheral leukocytes of patients with bladder cancer and healthy individuals
- Pre-treatment serum and plasma levels of matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of matrix metalloproteinases 1 (TIMP-1) in gastric cancer patients
- Infectious Disease
- Diagnosis of infection with human herpes viruses in routine laboratory practice
- Isolation and expression of UB05, a Plasmodium falciparum antigen recognised by antibodies from semi-immune adults in a high transmission endemic area of the Cameroonian rainforest
- Letters to the Editor
- Use of EDTA-plasma gel-separating tubes for measurement of indocyanine green
- Composition of cryoglobulin and cryoprecipitate
- Congress Abstracts
- Congress of Clinical Chemistry and Laboratory Medicine. 6th Annual Conference of the German Society for Clinical Chemistry and Laboratory Medicine (DGKL), Leipzig, Germany, October 7–10, 2009
- 8th Panhellenic Clinical Chemistry Congress, Patras, Greece, October 2–4, 2009
Schlagwörter für diesen Artikel
adiposity;
children;
diet;
gender interaction;
obesity;
peroxisome proliferator-activated receptor γ (PPARγ);
Pro12Ala polymorphism
Artikel in diesem Heft
- Editorials
- Estimating glomerular filtration rate
- Serum-free light chain analysis: works in progress
- Review
- Glomerular filtration rate measurement and prediction equations
- Genetics and Molecular Diagnostics
- Leptin gene (TTTC)n microsatellite polymorphism in pre-eclampsia and HELLP syndrome
- TaqIB polymorphism in cholesterol ester transfer protein (CETP) gene predicts future cardiovascular death in patients experiencing an acute coronary syndrome
- Peroxisome proliferator-activated receptor-γ (PPARγ) Pro12Ala polymorphism and risk for pediatric obesity
- Application of pyrosequencing to the identification of sequence variations in the cystic fibrosis transmembrane conductance regulator gene
- General Clinical Chemistry and Laboratory Medicine
- Relationship of serum bilirubin concentrations to kidney function and albuminuria in the United States adult population. Findings from the National Health and Nutrition Examination Survey 2001–2006
- Efficiency of test report delivery to the requesting physician in an outpatient setting: an observational study
- A case-control study on the relationship between HDL2b and non-alcoholic fatty liver disease in Chinese type 2 diabetic patients
- Preeclamptic placental stress and over expression of mitochondrial HSP70
- Reliability of two different bedside assays for C-reactive protein in newborn infants
- Clinical relevance of circulating midkine in ulcerative colitis
- First automated assay for thyrotropin receptor autoantibodies
- Serum concentrations of extracellular fatty acid synthase in patients with steatohepatitis
- Cancer Diagnostics
- Serum free light chains: diagnostic and prognostic value in multiple myeloma
- Quantitation of serum free light chains does not compensate for serum immunofixation only when screening for monoclonal gammopathies
- Serum HER-2 concentrations for monitoring women with breast cancer in a routine oncology setting
- Level of selenoprotein transcripts in peripheral leukocytes of patients with bladder cancer and healthy individuals
- Pre-treatment serum and plasma levels of matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of matrix metalloproteinases 1 (TIMP-1) in gastric cancer patients
- Infectious Disease
- Diagnosis of infection with human herpes viruses in routine laboratory practice
- Isolation and expression of UB05, a Plasmodium falciparum antigen recognised by antibodies from semi-immune adults in a high transmission endemic area of the Cameroonian rainforest
- Letters to the Editor
- Use of EDTA-plasma gel-separating tubes for measurement of indocyanine green
- Composition of cryoglobulin and cryoprecipitate
- Congress Abstracts
- Congress of Clinical Chemistry and Laboratory Medicine. 6th Annual Conference of the German Society for Clinical Chemistry and Laboratory Medicine (DGKL), Leipzig, Germany, October 7–10, 2009
- 8th Panhellenic Clinical Chemistry Congress, Patras, Greece, October 2–4, 2009
